Detailed information NTG0290112

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: CSC51_RS02555
• Genome accession: NZ_CP029080
• Coordinates: 490754..492115 (-)
• Length: 453 a.a.
• NCBI ID: WP_061544228.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain AR466
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	489428..513142	490754..492115	within	0

Gene organization within MGE regions

Location: 489428..513142

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CSC51_RS02555 (CSC51_0441)	ccrA	490754..492115 (-)	1362	WP_061544228.1	recombinase family protein	Machinery gene
CSC51_RS02560 (CSC51_0442)	-	492326..494092 (-)	1767	WP_061544227.1	DUF927 domain-containing protein	-
CSC51_RS02565 (CSC51_0443)	-	494092..494385 (-)	294	WP_046464617.1	hypothetical protein	-
CSC51_RS02570 (CSC51_0444)	-	494556..496070 (-)	1515	WP_108703122.1	hypothetical protein	-
CSC51_RS02575 (CSC51_0445)	-	496701..497612 (+)	912	WP_046464619.1	ABC transporter substrate-binding protein	-
CSC51_RS14470 (CSC51_0446)	-	497645..497815 (-)	171	WP_155734542.1	hypothetical protein	-
CSC51_RS02580	-	497862..498523 (-)	662	Protein_463	IS6 family transposase	-
CSC51_RS02585 (CSC51_0448)	-	498637..499593 (+)	957	WP_000282655.1	thymidylate synthase	-
CSC51_RS02590 (CSC51_0449)	-	499635..500120 (+)	486	WP_000175735.1	trimethoprim-resistant dihydrofolate reductase DfrS1	-
CSC51_RS02595 (CSC51_0450)	-	500130..500528 (+)	399	Protein_466	DegV family protein	-
CSC51_RS02600 (CSC51_0451)	-	500584..501258 (-)	675	WP_001106019.1	IS6-like element IS257 family transposase	-
CSC51_RS02605	-	501342..501683 (+)	342	WP_001797647.1	hydroxymethylglutaryl-CoA synthase	-
CSC51_RS02615 (CSC51_0453)	-	502560..503303 (+)	744	WP_000958858.1	glycerophosphoryl diester phosphodiesterase	-
CSC51_RS02620 (CSC51_0454)	-	503400..503828 (+)	429	WP_000872606.1	MaoC family dehydratase	-
CSC51_RS02625 (CSC51_0455)	mecA	503874..505883 (-)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
CSC51_RS02630 (CSC51_0456)	-	505980..506966 (+)	987	WP_001549960.1	beta-lactam sensor/signal transducer MecR1	-
CSC51_RS02635 (CSC51_0457)	-	506938..507198 (+)	261	WP_001549961.1	type I restriction enzyme endonuclease domain-containing protein	-
CSC51_RS02640 (CSC51_0458)	-	507189..508796 (-)	1608	Protein_474	IS1182 family transposase	-
CSC51_RS02645 (CSC51_0459)	-	508848..509354 (-)	507	WP_001092195.1	DUF1643 domain-containing protein	-
CSC51_RS02650 (CSC51_0460)	-	509369..509680 (-)	312	WP_001024803.1	DUF960 family protein	-
CSC51_RS02660 (CSC51_0461)	-	509767..510117 (-)	351	WP_070508371.1	SAUGI family uracil-DNA glycosylase inhibitor	-
CSC51_RS02665 (CSC51_0462)	-	510800..511390 (-)	591	WP_070508372.1	hypothetical protein	-
CSC51_RS02670 (CSC51_0463)	ccrB	511517..513142 (-)	1626	WP_108703123.1	recombinase family protein	Machinery gene

Sequence

Protein

• Length: 453 a.a.
• Molecular weight: 52936.78 Da
• Isoelectric Point: 9.8297

>NTDB_id=290112 CSC51_RS02555 WP_061544228.1 490754..492115(-) (ccrA) [Staphylococcus aureus strain AR466]
MEKAIAYVRQSTLKQQSLATQKSLIIDTAKQHGWSNVTFYDDKKTGGHTKRSGYQKMVEVITSGECKVLCCYRLNRLHRN
FKNAIQFFEICKKHHVTIISVNDGYFDLSKEFDCFRLNILMSLAEMESNNISEQTRNGIREKAKQGKLITTHAPFGYHYS
KGHFIVNAEEAPTIKAVYRWYLQGLGYKKISQKLDKDMNFISRKPYQVRNILLNPNYCGRVINKYGTFNDIVPPIINVDT
FEEAQERRIHKQHNRSNSRNKLKRRIKCPYCQSTLTNLTIKKEHRSLRYYVCPKNMNEAYHTCPFKGINAQMIETEVLNT
CKVYCGNQSFHDKLNETILKALKHQQMKHRQSHLTQEQLIEKLAQNQIDIETFKRLSAGFEREERYSNYSSNQIAETIRH
VVKDKLTLEIIAPLIDDITITQTKQLQGIYFKNSPLNIVEQSHLITPERNEVI

Nucleotide

• Length: 1362 bp

>NTDB_id=290112 CSC51_RS02555 WP_061544228.1 490754..492115(-) (ccrA) [Staphylococcus aureus strain AR466]
ATGGAAAAAGCCATTGCTTATGTACGTCAAAGTACACTCAAACAACAAAGCTTAGCGACTCAGAAATCCCTCATTATAGA
CACTGCTAAGCAACATGGATGGTCCAATGTAACATTTTATGATGATAAAAAAACAGGTGGACATACAAAGCGTTCAGGCT
ATCAAAAAATGGTAGAAGTGATTACATCTGGAGAGTGTAAAGTATTATGTTGCTATCGGCTAAATCGGCTCCATCGTAAT
TTCAAAAATGCTATACAATTCTTTGAAATTTGTAAAAAGCATCACGTCACAATCATCAGTGTTAACGATGGATATTTTGA
TTTGTCTAAAGAGTTTGATTGCTTTCGCTTAAACATACTCATGAGTCTAGCAGAAATGGAATCGAACAACATCAGCGAAC
AAACACGAAATGGGATAAGAGAAAAAGCCAAACAAGGTAAGTTGATTACAACACACGCCCCTTTTGGTTATCACTACAGC
AAAGGTCACTTTATTGTAAATGCAGAAGAAGCACCGACAATCAAAGCCGTTTATCGTTGGTATTTACAAGGACTTGGTTA
CAAGAAAATTTCTCAAAAGCTGGATAAAGATATGAATTTTATTTCTCGTAAGCCCTATCAAGTTAGAAATATTCTCTTGA
ACCCTAACTATTGTGGTCGTGTCATTAATAAATATGGAACGTTTAATGATATCGTTCCACCTATTATTAATGTTGATACG
TTTGAGGAAGCACAAGAGCGTCGTATTCATAAACAACACAATCGATCCAATTCTAGAAATAAGTTAAAGCGACGAATCAA
ATGTCCTTACTGTCAATCAACATTAACAAACTTAACGATAAAAAAAGAACATCGTTCTCTACGTTACTATGTCTGTCCTA
AAAATATGAATGAAGCCTATCATACGTGTCCATTTAAAGGCATCAATGCGCAAATGATTGAAACAGAGGTCCTAAACACT
TGTAAAGTATACTGTGGCAATCAATCATTTCATGACAAATTAAATGAGACAATACTAAAAGCTCTAAAACACCAACAAAT
GAAACACAGACAATCACATCTAACACAAGAACAACTCATCGAAAAACTAGCACAAAATCAAATTGATATAGAAACATTTA
AACGGTTATCTGCTGGCTTTGAAAGAGAAGAACGTTACTCTAATTATTCATCCAATCAAATTGCTGAAACAATCCGTCAT
GTAGTCAAAGATAAATTGACATTAGAAATCATAGCACCTTTGATTGATGACATTACAATAACTCAAACTAAACAATTACA
AGGAATCTACTTTAAAAACAGTCCACTCAATATCGTTGAACAATCGCATTTAATAACTCCTGAAAGGAATGAAGTCATAT
GA

Domains

Predicted by InterproScan.

• Resolvase, N terminal domain (Resolvase) (4-147)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

• Recombinase (Recombinase) (169-248)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus COL	55.305	97.792	0.541
ccrA	Staphylococcus aureus N315	52.37	97.792	0.512