Detailed information NTG0288274

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: C1A39_RS01650
• Genome accession: NZ_CP028896
• Coordinates: 299399..300916 (+)
• Length: 505 a.a.
• NCBI ID: WP_002949640.1
• Uniprot ID: A0A060BQ50
• Organism: Streptococcus thermophilus strain CS5
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 294399..305916

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C1A39_RS09775 (C1A39_01635)	-	294679..294849 (+)	171	Protein_269	ascorbate 6-phosphate lactonase	-
C1A39_RS01625 (C1A39_01640)	-	294866..295537 (-)	672	WP_002946492.1	TrkA family potassium uptake protein	-
C1A39_RS01630 (C1A39_01645)	-	295577..296941 (-)	1365	WP_276529255.1	potassium transporter TrkG	-
C1A39_RS01635 (C1A39_01650)	rsmG	297011..297724 (-)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
C1A39_RS01640 (C1A39_01655)	-	298021..298557 (+)	537	WP_014607968.1	YceD family protein	-
C1A39_RS01645 (C1A39_01660)	covR	298713..299402 (+)	690	WP_002949638.1	response regulator transcription factor	Regulator
C1A39_RS01650 (C1A39_01665)	covS	299399..300916 (+)	1518	WP_002949640.1	HAMP domain-containing histidine kinase	Regulator
C1A39_RS01655 (C1A39_01670)	nrdR	301038..301517 (+)	480	WP_011680738.1	transcriptional regulator NrdR	-
C1A39_RS01660 (C1A39_01675)	-	301514..302689 (+)	1176	WP_011680739.1	DnaD domain protein	-
C1A39_RS01665 (C1A39_01680)	dnaI	302693..303595 (+)	903	WP_014607971.1	primosomal protein DnaI	-
C1A39_RS01670 (C1A39_01685)	der	303701..305011 (+)	1311	WP_014607972.1	ribosome biogenesis GTPase Der	-
C1A39_RS10230	-	305075..305734 (+)	660	Protein_280	HI_0552 family protein	-

Sequence

Protein

• Length: 505 a.a.
• Molecular weight: 57536.93 Da
• Isoelectric Point: 5.2689

>NTDB_id=288274 C1A39_RS01650 WP_002949640.1 299399..300916(+) (covS) [Streptococcus thermophilus strain CS5]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide

• Length: 1518 bp

>NTDB_id=288274 C1A39_RS01650 WP_002949640.1 299399..300916(+) (covS) [Streptococcus thermophilus strain CS5]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (384-494)

• ArlS sensor domain (ArlS_N) (39-187)

• His Kinase A (phospho-acceptor) domain (HisKA) (270-329)

• HAMP domain (HAMP) (213-265)

3D structure

• AlphaFold DB: A0A060BQ50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Streptococcus salivarius strain HSISS4	94.622	99.406	0.941