Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   SM12261_RS09175 Genome accession   NZ_CP028414
Coordinates   1823715..1826147 (-) Length   810 a.a.
NCBI ID   WP_001109666.1    Uniprot ID   A0A0F2DH07
Organism   Streptococcus mitis NCTC 12261     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1818715..1831147
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS09145 (SM12261_1763) - 1818868..1819554 (-) 687 WP_000764010.1 DUF1275 family protein -
  SM12261_RS09150 (SM12261_1764) - 1819681..1820364 (-) 684 WP_000730894.1 hypothetical protein -
  SM12261_RS09155 (SM12261_1765) - 1820643..1820873 (+) 231 WP_000933124.1 hypothetical protein -
  SM12261_RS09160 (SM12261_1766) - 1820945..1821718 (-) 774 WP_000132693.1 NUDIX domain-containing protein -
  SM12261_RS09165 (SM12261_1767) pnuC 1821720..1822499 (-) 780 WP_000736875.1 nicotinamide riboside transporter PnuC -
  SM12261_RS09170 (SM12261_1768) - 1822509..1823567 (-) 1059 WP_000730574.1 AAA family ATPase -
  SM12261_RS09175 (SM12261_1769) clpC 1823715..1826147 (-) 2433 WP_001109666.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  SM12261_RS09180 (SM12261_1770) - 1826149..1826607 (-) 459 WP_001211265.1 CtsR family transcriptional regulator -
  SM12261_RS09185 (SM12261_1771) - 1826726..1827454 (-) 729 WP_000136238.1 ABC transporter ATP-binding protein -
  SM12261_RS09190 (SM12261_1772) - 1827454..1828461 (-) 1008 WP_000754556.1 ABC transporter substrate-binding protein -
  SM12261_RS09195 (SM12261_1773) - 1828500..1829258 (-) 759 WP_161969982.1 ABC transporter permease -
  SM12261_RS09200 (SM12261_1774) - 1829221..1829511 (-) 291 WP_000647684.1 thiamine-binding protein -
  SM12261_RS09205 (SM12261_1775) cbpD 1829764..1830873 (-) 1110 WP_000798432.1 choline binding-anchored murein hydrolase CbpD Auxiliary factor

Sequence

Protein


Download         Length: 810 a.a.        Molecular weight: 90191.94 Da        Isoelectric Point: 5.9151

>NTDB_id=284666 SM12261_RS09175 WP_001109666.1 1823715..1826147(-) (clpC) [Streptococcus mitis NCTC 12261]
MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF
SHRLQVLFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMIILQGLKATYEKHHRVQITDEAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKHVKADDSGLSPADKALIDGKWKQAAQLIAKEEEVPVYKDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRIFEELKKTYRPEFINRIDEKVVFHSLDS
DHMQEIVKIMVKPLIASLAEKGIDLKLQASALKLLASHGYNPEMGARPLRRTLQTEVEDKLAELLLKGELEAGSTLKIGV
KAGQLKFDIV

Nucleotide


Download         Length: 2433 bp        

>NTDB_id=284666 SM12261_RS09175 WP_001109666.1 1823715..1826147(-) (clpC) [Streptococcus mitis NCTC 12261]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTGGCTGGCCATTTTGGAGCTCGTTACCTAGA
GTCTTGGCACTTGTTGATTGCCATGTCTAATCACAGTTATAGTGTGGCAGGGGCGACTTTAAATGATTATCCATATGAGA
TGGACCGTTTAGAAGAGGTCGCTTTGGAACTGACTGAAACGGACTATAGCCAGGATGAAACCTTTACGGAATTGCCGTTT
TCTCATCGTTTGCAGGTCCTTTTTGACGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCTAAGGTGCTAGGGACAGAGCA
TGTCCTCTATGCGATTTTGCATGATGGCAATGCCTTGGCGACTCGTATCTTGGAGAGAGCTGGTTTTTCTTATGAAGACA
AGAAAGATCAGGTCAAGATTGCTGCCCTACGTCGAAATCTAGAAGAACGAGCAGGTTGGACTCGTGAAGATCTCAAGGCT
TTACGCCAACGCCATCGTACAGTAGCTGATAAGCAAAATTCTATGGCTAATATGATGGGCATGCCCCAGACTCCAAGCGG
TGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCGCGTTCTGGCAAGTTAGAGCCAGTTATCGGTCGGGACAAGG
AAATCTCGCGTATGATTCAAATTTTGAGTCGGAAGACTAAGAATAATCCTGTCTTGGTTGGGGATGCTGGTGTCGGAAAA
ACAGCTCTGGCGCTTGGACTTGCCCAGCGTATTGCTAGTGGGGACGTGCCTGCGGAAATGGCTAAGATGCGCGTGTTAGA
GCTGGATTTGATGAATGTCGTTGCAGGGACACGCTTCCGTGGTGACTTTGAAGAGCGCATGAATAATATCATCAAGGATA
TTGAGGAAGATGGTCAAGTAATTCTCTTTATCGATGAACTCCACACTATCATGGGTTCTGGTAGTGGAATTGACTCAACT
CTGGATGCGGCCAATATCTTGAAACCAGCCTTGGCGCGTGGAACTTTGAGAACGGTTGGTGCGACCACTCAGGAAGAATA
TCAAAAACACATCGAAAAAGATGCGGCCCTTTCTCGTCGTTTCGCGAAAGTGACGATTGAAGAGCCAAGCGTGGCCGACA
GTATGATCATTTTACAGGGTTTGAAGGCGACTTATGAGAAACATCACCGTGTGCAAATCACAGATGAAGCAGTTGAAACA
GCTGTCAAGATGGCTCATCGTTACTTGACTAGTCGTCACTTGCCAGACTCTGCTATTGATCTCTTGGATGAAGCAGCAGC
AACAGTGCAAAATAAGGCTAAGCATGTAAAAGCAGACGATTCAGGTTTGAGTCCAGCTGACAAGGCCTTGATAGATGGTA
AGTGGAAACAGGCAGCTCAGTTAATCGCAAAAGAAGAGGAAGTGCCTGTCTATAAAGACTTGGTGACAGAGTCTGATATT
TTGACCACCTTGAGTCGCTTGTCAGGTATTCCAGTCCAAAAACTGACTCAGACTGATGCTAAGAAATACCTAAACTTGGA
AGCTGAACTGCACAAACGTGTCATCGGTCAAGATCAAGCTGTTTCAAGTATTAGCCGTGCCATTCGCCGCAATCAGTCAG
GGATTCGCAGTCACAAGCGTCCGATTGGTTCCTTTATGTTCCTAGGACCTACAGGTGTCGGTAAGACCGAATTGGCCAAG
GCTCTAGCAGAAGTTCTTTTTGATGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTTGCAGC
CAGTCGTCTCAACGGAGCTCCTCCAGGCTATGTGGGGTATGAAGAAGGTGGGGAGTTGACCGAGAAGGTTCGCAACAAAC
CATACTCTGTTCTCCTCTTTGATGAGGTAGAAAAAGCCCACCCAGACATCTTTAATGTCCTCTTGCAGGTCTTGGATGAT
GGTGTCTTGACAGATAGCAAGGGGCGCAAGGTTGACTTTTCAAATACCATTATCATCATGACGTCAAATCTTGGTGCGAC
AGCCCTTCGGGATGACAAGACCGTCGGTTTTGGAGCTAAGGATATTCGTTTTGATCAGGAAAATATGGAAAAACGAATCT
TTGAAGAGTTGAAAAAAACTTATCGACCAGAGTTTATCAACCGTATTGATGAAAAGGTGGTCTTCCACAGTTTGGATAGC
GACCACATGCAGGAAATTGTCAAGATTATGGTTAAACCATTGATTGCTAGCCTGGCAGAGAAGGGCATCGACTTAAAACT
ACAAGCTTCGGCACTGAAGTTGCTAGCTAGTCACGGTTACAATCCAGAAATGGGAGCTCGTCCACTTCGCAGAACCCTAC
AAACAGAAGTGGAAGACAAGTTGGCAGAACTTCTTCTCAAGGGAGAATTAGAGGCAGGCAGCACACTTAAGATTGGTGTT
AAAGCAGGCCAGTTAAAATTTGATATTGTATAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(231-362)

AAA lid domain (AAA_lid_9)

(370-439)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(718-798)

AAA domain (Cdc48 subfamily) (AAA_2)

(540-711)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(103-139)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F2DH07

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae TIGR4

98.022

99.877

0.979
  clpC Streptococcus pneumoniae Rx1

98.022

99.877

0.979
  clpC Streptococcus pneumoniae D39

98.022

99.877

0.979
  clpC Streptococcus mutans UA159

67.445

100

0.678
  clpC Streptococcus thermophilus LMD-9

66.503

100

0.669
  clpC Streptococcus thermophilus LMG 18311

66.38

100

0.668
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

49.095

100

0.502
  clpC Bacillus subtilis subsp. subtilis str. 168

44.994

99.877

0.449
  clpE Streptococcus mutans UA159

48.674

79.136

0.385
  clpE Streptococcus pneumoniae Rx1

46.835

78.025

0.365
  clpE Streptococcus pneumoniae D39

46.835

78.025

0.365
  clpE Streptococcus pneumoniae R6

46.835

78.025

0.365
  clpC Lactococcus lactis subsp. cremoris KW2

46.955

77.037

0.362

Multiple sequence alignment