Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   SM12261_RS07705 Genome accession   NZ_CP028414
Coordinates   1519237..1519926 (-) Length   229 a.a.
NCBI ID   WP_000518021.1    Uniprot ID   -
Organism   Streptococcus mitis NCTC 12261     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1514237..1524926
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM12261_RS07680 (SM12261_1485) - 1515112..1516119 (-) 1008 WP_000562409.1 phosphomevalonate kinase -
  SM12261_RS07685 (SM12261_1486) mvaD 1516106..1517059 (-) 954 WP_000373450.1 diphosphomevalonate decarboxylase -
  SM12261_RS07690 (SM12261_1487) mvk 1517041..1517919 (-) 879 WP_000163302.1 mevalonate kinase -
  SM12261_RS07700 (SM12261_1488) - 1518195..1519136 (-) 942 WP_078228276.1 N-acetylmuramoyl-L-alanine amidase family protein -
  SM12261_RS07705 (SM12261_1489) covR 1519237..1519926 (-) 690 WP_000518021.1 response regulator transcription factor Regulator
  SM12261_RS07710 (SM12261_1490) gndA 1519938..1521362 (-) 1425 WP_000158771.1 NADP-dependent phosphogluconate dehydrogenase -
  SM12261_RS07715 (SM12261_1491) mapZ 1521438..1522847 (-) 1410 WP_000039297.1 cell division site-positioning protein MapZ -
  SM12261_RS07720 (SM12261_1492) - 1522861..1524018 (-) 1158 WP_000711362.1 THUMP domain-containing class I SAM-dependent RNA methyltransferase -
  SM12261_RS07730 (SM12261_1493) gpsB 1524504..1524833 (-) 330 WP_000146535.1 cell division regulator GpsB -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26815.98 Da        Isoelectric Point: 8.0259

>NTDB_id=284655 SM12261_RS07705 WP_000518021.1 1519237..1519926(-) (covR) [Streptococcus mitis NCTC 12261]
MGKRILLLEKERNLAHFLSLELQKEQYRVDQVEEGQKALFMALQTDYDLILLNARLGDMTAQDFADKLSRTKPASVIMVL
DHREELQDQIEAIQRFAVSYIYKPVIIDNLVARISAIFRGRDFIDQHCSQMKVPTSYRNLRMDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=284655 SM12261_RS07705 WP_000518021.1 1519237..1519926(-) (covR) [Streptococcus mitis NCTC 12261]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAAAAAGAGCAATA
CCGAGTTGATCAGGTTGAGGAGGGGCAAAAAGCCCTCTTCATGGCTCTTCAGACAGACTATGACTTGATTTTATTGAATG
CTCGTCTGGGGGATATGACAGCCCAGGATTTTGCAGATAAGCTGAGTCGTACTAAGCCAGCCTCAGTCATCATGGTCTTG
GACCATCGTGAAGAATTGCAAGATCAGATTGAGGCAATCCAACGCTTTGCCGTTTCTTACATCTATAAGCCGGTTATTAT
TGACAATTTGGTGGCCCGTATTTCAGCGATTTTCCGAGGTCGGGACTTTATCGACCAACACTGTAGTCAGATGAAGGTTC
CAACGTCTTATCGCAATCTGCGTATGGATGTAGAACATCATACCGTTTATCGTGGCGAAGAGATGATTGCTCTGACCCGT
CGTGAGTATGACCTCTTGGCTACTCTTATGGGAAGCAAGAAAGTTCTGACTCGTGAGCAGTTATTGGAAAGTGTCTGGAA
GTATGAAAGTGCGACCGAAACAAATATCGTGGATGTCTATATCCGTTATCTACGTAGCAAGCTTGATGTAAAAGGTCAAA
AAAGCTACATTAAAACCGTGCGTGGTGTCGGTTACACCATGCAAGAATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-226)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

48.696

100

0.489
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.491

99.563

0.463

Multiple sequence alignment