Detailed information NTG0281810

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: LL14B4_RS08360
• Genome accession: NZ_CP028160
• Coordinates: 1704950..1706425 (-)
• Length: 491 a.a.
• NCBI ID: WP_010906048.1
• Uniprot ID: A0A2A9ICZ0
• Organism: Lactococcus lactis subsp. lactis strain 14B4
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1699950..1711425

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LL14B4_RS08345 (LL14B4_08335)	murD	1701210..1702562 (-)	1353	WP_003130748.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
LL14B4_RS08350 (LL14B4_08340)	-	1703053..1703394 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
LL14B4_RS08355 (LL14B4_08345)	-	1703526..1704767 (-)	1242	WP_033898637.1	ammonium transporter	-
LL14B4_RS08360 (LL14B4_08350)	covS	1704950..1706425 (-)	1476	WP_010906048.1	HAMP domain-containing sensor histidine kinase	Regulator
LL14B4_RS08365 (LL14B4_08355)	covR	1706434..1707126 (-)	693	WP_003130756.1	response regulator transcription factor	Regulator
LL14B4_RS08370 (LL14B4_08360)	-	1707282..1707812 (-)	531	WP_033898640.1	YceD family protein	-
LL14B4_RS08375 (LL14B4_08365)	-	1707943..1708188 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
LL14B4_RS08380 (LL14B4_08370)	-	1708344..1708808 (-)	465	WP_017864799.1	hypothetical protein	-
LL14B4_RS08385 (LL14B4_08375)	-	1708890..1709252 (-)	363	WP_010906050.1	TIGR02328 family protein	-
LL14B4_RS08395 (LL14B4_08385)	-	1709720..1710250 (-)	531	WP_033898642.1	CHAP domain-containing protein	-
LL14B4_RS08400 (LL14B4_08390)	-	1710312..1711148 (-)	837	WP_032946821.1	metallophosphoesterase	-

Sequence

Protein

• Length: 491 a.a.
• Molecular weight: 56195.08 Da
• Isoelectric Point: 4.8253

>NTDB_id=281810 LL14B4_RS08360 WP_010906048.1 1704950..1706425(-) (covS) [Lactococcus lactis subsp. lactis strain 14B4]
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQQLLTRSMDSVEEVLEKADAPL
NSSNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRHTFGFQNQANNEMKEIRGENPGYLVQRKII
SKSTGQVVGYLQAFYDTTTYHRISNLLLIVLLILEIVALIVAQLIGYFMANYFMKPLEKLYQGMQEMANDPTNDFEPIEI
QSGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVCNRALKNFQLLHDDFEIVLDNRLIYPTHARISENHFEQGLRILLDNAAKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGISEEDINHLFERFFRADKARNREIGGTGLGLSILARLAENYQGEIEVNSELGLG
STFTLKFPKIK

Nucleotide

• Length: 1476 bp

>NTDB_id=281810 LL14B4_RS08360 WP_010906048.1 1704950..1706425(-) (covS) [Lactococcus lactis subsp. lactis strain 14B4]
ATGAAAAAATTATTTACTTTCAATAAGAAAAAAGAGACGGTAGAGGAAAGTTCGGCTAAGCGGTCTATCATGCTTAGGTG
GGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTTTGTTTGCTACTTTGACTTATCAATTGACAATAAGTTCTT
TTATTAAAGAAGAACAACAATTATTAACTCGCTCTATGGATAGTGTTGAGGAAGTCTTAGAAAAAGCAGATGCTCCTTTG
AATTCATCGAATTTGAACACATATATTGAAGCGACATCAAAGATTCAAAATGGTGAGTCTGAAGGAATGAGTTTGGGTAG
TATCATTGGGACACGGAAAGCATTTTATATTTATGACTTAAATCATAAATTATTGTATTCAACGAATCGACATACTTTTG
GTTTTCAGAATCAGGCTAATAATGAAATGAAAGAGATTCGGGGAGAAAATCCAGGTTATTTAGTTCAGAGAAAAATTATT
TCTAAGTCAACAGGACAAGTTGTGGGATACTTACAGGCTTTTTATGATACGACGACTTATCATCGAATTTCTAATCTTCT
TTTGATTGTCTTGTTAATTTTAGAAATTGTTGCCTTGATTGTCGCTCAGTTGATTGGTTATTTCATGGCGAATTACTTTA
TGAAACCATTGGAAAAACTTTATCAGGGCATGCAAGAAATGGCAAATGATCCAACAAATGATTTTGAACCGATTGAAATT
CAAAGTGGAGATGAAATCGAAGAGTTGGCTCATGTTTACAATGATATGATGTTGAAGATGAAGGCATATCTTGAACAGCA
AAATCGCTTTGTTTCTGATGTTTCTCATGAATTAAGAACACCTTTAGCTGTCTTGGATGGACATATTAACTTGTTGAATC
GATGGGGGAAAAATGATCCAGAAGTATTAGATGAATCTTTGCAGGCAAGTTTAGATGAAGTTGATCGAATGAAGAAAATG
CTTGAGGAGATGTTGGCTCTTGCTCGCCTTGAAAATGTTGACTTATCAAGTGAAGAACTGGATTGTGATGTTGGAAAAGT
TTGTAATCGGGCCCTTAAGAATTTTCAGCTTTTGCATGATGATTTTGAAATAGTGCTTGATAACCGGCTTATTTATCCCA
CTCATGCGCGAATTTCAGAAAATCATTTTGAACAAGGTTTACGAATTCTGTTAGATAATGCTGCTAAATACTCTCCTGAT
GATCGTAAAGAAATCGTGATTACTGTTTCTGAGGATGAACAGTTTGTGATTACGAGTGTATCTGACAAAGGAATTGGAAT
TTCAGAAGAAGATATTAATCATCTTTTTGAGCGTTTCTTTAGAGCGGACAAGGCTCGCAATCGAGAAATTGGTGGAACTG
GTTTAGGTTTATCAATTTTAGCTCGATTGGCAGAAAATTATCAAGGGGAAATTGAGGTAAATTCAGAACTGGGTCTTGGT
TCAACTTTTACACTAAAATTCCCGAAAATAAAATAA

Domains

Predicted by InterproScan.

• ArlS sensor domain (ArlS_N) (54-185)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (380-489)

• HAMP domain (HAMP) (208-258)

• His Kinase A (phospho-acceptor) domain (HisKA) (267-332)

3D structure

• AlphaFold DB: A0A2A9ICZ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Lactococcus lactis subsp. lactis strain DGCC12653	100	100	1