Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   MGAS27961_RS02635 Genome accession   NZ_CP032665
Coordinates   509292..509933 (+) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain MGAS27961     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 504292..514933
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS27961_RS02615 (MGAS27961_02615) - 504848..505588 (+) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -
  MGAS27961_RS02620 (MGAS27961_02620) pknB 505585..507483 (+) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  MGAS27961_RS02625 (MGAS27961_02625) liaF 507606..508298 (+) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  MGAS27961_RS02630 (MGAS27961_02630) - 508295..509299 (+) 1005 WP_002991890.1 sensor histidine kinase -
  MGAS27961_RS02635 (MGAS27961_02635) vraR 509292..509933 (+) 642 WP_002983671.1 response regulator transcription factor Regulator
  MGAS27961_RS02640 (MGAS27961_02640) - 509970..511370 (+) 1401 WP_021340868.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  MGAS27961_RS02645 (MGAS27961_02645) - 511370..511747 (+) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  MGAS27961_RS02650 (MGAS27961_02650) cysK 511765..512706 (-) 942 WP_011285046.1 cysteine synthase A -
  MGAS27961_RS02655 (MGAS27961_02655) - 512834..513466 (-) 633 WP_002988970.1 YigZ family protein -
  MGAS27961_RS02660 (MGAS27961_02660) comFA/cflA 513522..514847 (+) 1326 WP_011285044.1 DEAD/DEAH box helicase Machinery gene

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=277273 MGAS27961_RS02635 WP_002983671.1 509292..509933(+) (vraR) [Streptococcus pyogenes strain MGAS27961]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=277273 MGAS27961_RS02635 WP_002983671.1 509292..509933(+) (vraR) [Streptococcus pyogenes strain MGAS27961]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTTCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385