Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraS   Type   Regulator
Locus tag   RK73_RS07210 Genome accession   NZ_CP026960
Coordinates   1357209..1358252 (-) Length   347 a.a.
NCBI ID   WP_001017131.1    Uniprot ID   A0A0D1IMN4
Organism   Staphylococcus aureus strain FDAARGOS_15     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1349511..1382539 1357209..1358252 within 0


Gene organization within MGE regions


Location: 1349511..1382539
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RK73_RS07165 (RK73_07165) - 1349511..1350557 (+) 1047 WP_001145732.1 tyrosine-type recombinase/integrase -
  RK73_RS07170 (RK73_07170) yfkAB 1350602..1351747 (+) 1146 WP_001245448.1 radical SAM/CxCxxxxC motif protein YfkAB -
  RK73_RS07175 (RK73_07175) - 1352007..1352537 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  RK73_RS07180 (RK73_07180) - 1352627..1353883 (-) 1257 WP_001795438.1 aminopeptidase -
  RK73_RS07185 (RK73_07185) - 1353886..1354086 (-) 201 WP_000180461.1 DUF1128 family protein -
  RK73_RS07190 (RK73_07190) - 1354233..1354697 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  RK73_RS07195 (RK73_07195) - 1354704..1354979 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  RK73_RS07200 (RK73_07200) - 1355257..1356474 (+) 1218 WP_000037075.1 YihY/virulence factor BrkB family protein -
  RK73_RS07205 (RK73_07205) vraR 1356590..1357219 (-) 630 WP_000153530.1 two-component system response regulator VraR Regulator
  RK73_RS07210 (RK73_07210) vraS 1357209..1358252 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  RK73_RS07215 (RK73_07215) liaF 1358249..1358950 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  RK73_RS07220 (RK73_07220) - 1358965..1359351 (-) 387 WP_001110179.1 hypothetical protein -
  RK73_RS07225 (RK73_07225) map 1359568..1360326 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  RK73_RS07240 (RK73_07240) - 1360854..1361840 (+) 987 WP_000999713.1 FUSC family protein -
  RK73_RS07250 (RK73_07250) - 1362271..1362684 (-) 414 WP_001549145.1 hypothetical protein -
  RK73_RS07255 (RK73_07255) - 1362713..1362823 (-) 111 WP_001790257.1 hypothetical protein -
  RK73_RS07260 (RK73_07260) - 1362909..1363640 (-) 732 WP_000544969.1 type 1 glutamine amidotransferase -
  RK73_RS07265 (RK73_07265) murT 1363642..1364955 (-) 1314 WP_001250336.1 lipid II isoglutaminyl synthase subunit MurT -
  RK73_RS07270 (RK73_07270) ftnA 1365247..1365747 (+) 501 WP_000949467.1 H-type ferritin FtnA -
  RK73_RS07275 (RK73_07275) - 1365829..1365921 (-) 93 WP_001790679.1 hypothetical protein -
  RK73_RS07280 (RK73_07280) - 1366136..1366690 (+) 555 WP_000613733.1 3'-5' exonuclease -
  RK73_RS07285 (RK73_07285) dinB 1366758..1367828 (-) 1071 WP_000140176.1 DNA polymerase IV -
  RK73_RS07290 (RK73_07290) - 1368075..1368605 (-) 531 WP_000548781.1 DUF3267 domain-containing protein -
  RK73_RS07295 (RK73_07295) rlmD 1368775..1370136 (-) 1362 WP_001147868.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
  RK73_RS07300 (RK73_07300) - 1370217..1371164 (-) 948 WP_001231451.1 diacylglycerol kinase -
  RK73_RS07310 (RK73_07310) - 1371747..1371893 (-) 147 WP_001797372.1 hypothetical protein -
  RK73_RS07315 (RK73_07315) gatB 1371933..1373360 (-) 1428 WP_000545370.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
  RK73_RS07320 (RK73_07320) gatA 1373373..1374830 (-) 1458 WP_000027928.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
  RK73_RS07325 (RK73_07325) gatC 1374832..1375134 (-) 303 WP_000170162.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
  RK73_RS07330 (RK73_07330) putP 1375501..1377039 (+) 1539 WP_000957020.1 sodium/proline symporter PutP -
  RK73_RS07335 (RK73_07335) - 1377128..1378327 (-) 1200 WP_000831698.1 CamS family sex pheromone protein -
  RK73_RS07340 (RK73_07340) ligA 1378340..1380343 (-) 2004 WP_000774565.1 NAD-dependent DNA ligase LigA -
  RK73_RS07345 (RK73_07345) pcrA 1380347..1382539 (-) 2193 WP_000992921.1 DNA helicase PcrA -

Sequence

Protein


Download         Length: 347 a.a.        Molecular weight: 40044.52 Da        Isoelectric Point: 6.0577

>NTDB_id=273896 RK73_RS07210 WP_001017131.1 1357209..1358252(-) (vraS) [Staphylococcus aureus strain FDAARGOS_15]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide


Download         Length: 1044 bp        

>NTDB_id=273896 RK73_RS07210 WP_001017131.1 1357209..1358252(-) (vraS) [Staphylococcus aureus strain FDAARGOS_15]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(249-340)

Histidine kinase (HisKA_3)

(147-210)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0D1IMN4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraS Staphylococcus aureus N315

100

100

1

Multiple sequence alignment