Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   C2E56_RS03840 Genome accession   NZ_CP026084
Coordinates   705828..707177 (+) Length   449 a.a.
NCBI ID   WP_001065469.1    Uniprot ID   R4ZB13
Organism   Streptococcus agalactiae strain NJ1606     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 700828..712177
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C2E56_RS03810 (C2E56_03930) - 701234..701800 (+) 567 WP_000592388.1 PepSY domain-containing protein -
  C2E56_RS03815 (C2E56_03935) - 701849..702499 (-) 651 WP_000100034.1 amino acid ABC transporter permease -
  C2E56_RS03820 (C2E56_03940) - 702511..703206 (-) 696 WP_000173639.1 amino acid ABC transporter permease -
  C2E56_RS03825 (C2E56_03945) - 703219..704019 (-) 801 WP_000946173.1 transporter substrate-binding domain-containing protein -
  C2E56_RS03830 (C2E56_03950) - 704031..704786 (-) 756 WP_000053148.1 amino acid ABC transporter ATP-binding protein -
  C2E56_RS03835 (C2E56_03955) vicR 705125..705835 (+) 711 WP_000722052.1 response regulator YycF Regulator
  C2E56_RS03840 (C2E56_03960) vicK 705828..707177 (+) 1350 WP_001065469.1 cell wall metabolism sensor histidine kinase VicK Regulator
  C2E56_RS03845 (C2E56_03965) vicX 707181..707990 (+) 810 WP_001289498.1 MBL fold metallo-hydrolase Regulator
  C2E56_RS03850 (C2E56_03970) - 707993..708361 (+) 369 WP_000719384.1 YbaN family protein -
  C2E56_RS03855 (C2E56_03975) rnc 708536..709222 (+) 687 WP_000661527.1 ribonuclease III -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 51059.13 Da        Isoelectric Point: 4.8621

>NTDB_id=266947 C2E56_RS03840 WP_001065469.1 705828..707177(+) (vicK) [Streptococcus agalactiae strain NJ1606]
MNNSAANIRSFELALLFLLVFVAVYFVYLAVRDFKMSKNIRLLNWKVRDLIAGNYSDSILIQGDADLVELGESLNDLSDV
FRMAHDNLEQEKNRLASILTYMTDGVLATDRSGKIVMINETAQQQFNLAYDEALSMNIVDMLGSGSPYSFQDLVSKTPEV
VLNRRDENGEFVTLRIRFALNRRESGFISGLVAVSHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALNE
EVAPSFIKVSLDETNRMMRMISDLLSLSRIDNEVTHLDVEMTNFTAFMTSILNRFDQIRNQKTVTGKVYEIVRDYPLKSI
WVEIDTDKMTQVIDNILNNAVKYSPDGGKITVNLRTTKTQMILSISDQGLGIPKKDLPLIFDRFYRVDKARSRQQGGTGL
GLSIAKEIVKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVTYEEWEDVED

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=266947 C2E56_RS03840 WP_001065469.1 705828..707177(+) (vicK) [Streptococcus agalactiae strain NJ1606]
ATGAATAATAGTGCTGCAAATATTAGGTCGTTTGAGCTAGCCTTACTTTTTTTACTAGTTTTTGTTGCTGTTTATTTTGT
TTATCTAGCGGTTAGAGATTTTAAAATGTCTAAAAATATCCGACTTTTGAATTGGAAAGTCAGAGATTTGATAGCAGGAA
ATTATTCAGATAGTATTCTAATTCAAGGTGATGCAGATTTGGTAGAATTAGGTGAAAGTCTAAATGATTTATCTGATGTC
TTCCGAATGGCACATGATAACTTAGAACAAGAAAAGAATCGCTTAGCAAGTATCTTAACTTATATGACTGACGGTGTGCT
GGCTACAGATCGTTCAGGAAAAATCGTTATGATTAATGAGACAGCCCAACAGCAGTTCAATTTAGCATATGATGAAGCTT
TATCAATGAATATTGTTGATATGTTAGGGTCAGGAAGTCCATATTCGTTCCAAGATTTAGTCTCTAAGACGCCAGAGGTA
GTTCTTAATAGACGTGATGAAAATGGTGAATTTGTTACCTTACGGATTCGATTTGCTTTGAACCGCCGTGAAAGTGGTTT
TATTTCCGGTTTAGTTGCAGTATCACACGATGCTACTGAGCAAGAGAAAGAAGAGCGAGAAAGAAGACTTTTTGTATCTA
ATGTTTCTCATGAACTTCGTACACCTTTGACATCTGTAAAATCTTATTTAGAAGCTTTAGATGAGGGAGCGCTCAATGAA
GAAGTTGCTCCAAGCTTCATTAAGGTATCTCTAGATGAAACAAATCGTATGATGCGTATGATATCAGATTTATTAAGTTT
ATCGCGCATTGATAATGAAGTAACGCATTTAGATGTTGAAATGACGAATTTTACAGCTTTCATGACCTCAATTTTGAATC
GATTTGACCAGATTAGAAATCAAAAAACAGTCACAGGAAAAGTTTATGAAATTGTCAGAGATTATCCTCTTAAGTCAATT
TGGGTGGAAATTGATACAGATAAGATGACTCAAGTGATTGATAACATTTTAAATAATGCAGTCAAGTATTCACCAGATGG
TGGTAAGATCACAGTTAATCTACGCACAACTAAAACGCAGATGATTTTATCAATATCAGACCAAGGCTTAGGTATTCCTA
AAAAAGATTTACCTCTCATCTTTGATCGTTTTTATCGTGTTGATAAGGCGAGAAGTCGTCAACAGGGTGGGACTGGACTT
GGTTTGTCAATTGCAAAAGAAATTGTTAAGCAGCATAAGGGATTTATTTGGGCTAAGAGTGAGTATGGTAAAGGGTCTAC
TTTTACAATAGTCTTGCCTTATGATAAAGATGCTGTAACTTATGAAGAATGGGAGGACGTTGAAGATTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-435)

PAS fold (PAS)

(94-180)

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB R4ZB13

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

74.576

91.982

0.686
  micB Streptococcus pneumoniae Cp1015

67.436

96.437

0.65

Multiple sequence alignment