Detailed information NTG0266312

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RK77_RS11755
• Genome accession: NZ_CP026064
• Coordinates: 2312179..2313222 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain FDAARGOS_19
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2307179..2318222

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RK77_RS11720 (RK77_011720)	-	2307607..2307717 (+)	111	WP_001790257.1	hypothetical protein	-
RK77_RS11725 (RK77_011725)	-	2307746..2308159 (+)	414	WP_001670387.1	hypothetical protein	-
RK77_RS11735 (RK77_011735)	-	2308590..2309576 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
RK77_RS11740 (RK77_011740)	map	2310105..2310863 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RK77_RS11745 (RK77_011745)	-	2311080..2311466 (+)	387	WP_001110179.1	hypothetical protein	-
RK77_RS11750 (RK77_011750)	liaF	2311481..2312182 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RK77_RS11755 (RK77_011755)	vraS	2312179..2313222 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RK77_RS11760 (RK77_011760)	vraR	2313212..2313841 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
RK77_RS11765 (RK77_011765)	-	2313954..2315171 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
RK77_RS11770 (RK77_011770)	-	2315449..2315724 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
RK77_RS11775 (RK77_011775)	-	2315731..2316195 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RK77_RS11780 (RK77_011780)	-	2316342..2316542 (+)	201	WP_000180460.1	DUF1128 family protein	-
RK77_RS11785 (RK77_011785)	-	2316545..2317801 (+)	1257	WP_075583716.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=266312 RK77_RS11755 WP_001017131.1 2312179..2313222(+) (vraS) [Staphylococcus aureus strain FDAARGOS_19]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=266312 RK77_RS11755 WP_001017131.1 2312179..2313222(+) (vraS) [Staphylococcus aureus strain FDAARGOS_19]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1