Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   DXE55_RS12805 Genome accession   NZ_CP031341
Coordinates   2462522..2463178 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli O145 strain RM12275-C1     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2457522..2468178
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DXE55_RS12770 (DXE55_13225) - 2457669..2458882 (+) 1214 WP_136952279.1 IS3 family transposase -
  DXE55_RS27340 - 2458925..2459095 (-) 171 Protein_2458 hypothetical protein -
  DXE55_RS12795 (DXE55_13250) pgsA 2460088..2460636 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  DXE55_RS12800 (DXE55_13255) uvrC 2460693..2462525 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  DXE55_RS12805 (DXE55_13260) letA 2462522..2463178 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  DXE55_RS12810 (DXE55_13265) yecU 2463474..2463650 (+) 177 WP_001307856.1 protein YecU -
  DXE55_RS12815 (DXE55_13270) yecF 2463637..2463861 (+) 225 WP_000106476.1 DUF2594 family protein YecF -
  DXE55_RS12820 (DXE55_13275) sdiA 2463929..2464651 (-) 723 WP_001154283.1 transcriptional regulator SdiA -
  DXE55_RS12825 (DXE55_13280) tcyN 2464881..2465633 (-) 753 WP_001272991.1 L-cystine ABC transporter ATP-binding protein TcyN -
  DXE55_RS12830 (DXE55_13285) tcyL 2465630..2466298 (-) 669 WP_001158220.1 cystine ABC transporter permease -
  DXE55_RS12835 (DXE55_13290) dcyD 2466313..2467299 (-) 987 WP_001128215.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=264883 DXE55_RS12805 WP_000611328.1 2462522..2463178(-) (letA) [Escherichia coli O145 strain RM12275-C1]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=264883 DXE55_RS12805 WP_000611328.1 2462522..2463178(-) (letA) [Escherichia coli O145 strain RM12275-C1]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATCCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482