Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   DW289_RS24090 Genome accession   NZ_CP031321
Coordinates   4713545..4714201 (-) Length   218 a.a.
NCBI ID   WP_000611335.1    Uniprot ID   Q3Z2T8
Organism   Escherichia coli strain ST2350 isolate Es_ST2350_SE1_NDM_03_2018     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 4708545..4719201
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DW289_RS24060 (DW289_24060) yecA 4709797..4710462 (-) 666 WP_000847902.1 UPF0149 family protein YecA -
  DW289_RS24080 (DW289_24080) pgsA 4711111..4711659 (-) 549 WP_001160188.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  DW289_RS24085 (DW289_24085) uvrC 4711716..4713548 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  DW289_RS24090 (DW289_24090) letA 4713545..4714201 (-) 657 WP_000611335.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  DW289_RS26255 - 4714343..4714414 (+) 72 Protein_4408 transcriptional regulator -
  DW289_RS25480 yecU 4714497..4714673 (+) 177 WP_000590347.1 protein YecU -
  DW289_RS24095 (DW289_24095) yecF 4714660..4714884 (+) 225 WP_000106474.1 DUF2594 family protein YecF -
  DW289_RS24100 (DW289_24100) sdiA 4714951..4715673 (-) 723 WP_001154279.1 transcriptional regulator SdiA -
  DW289_RS24105 (DW289_24105) tcyN 4715903..4716655 (-) 753 WP_115431731.1 L-cystine ABC transporter ATP-binding protein TcyN -
  DW289_RS24110 (DW289_24110) tcyL 4716652..4717320 (-) 669 WP_001158220.1 cystine ABC transporter permease -
  DW289_RS24115 (DW289_24115) dcyD 4717335..4718321 (-) 987 WP_001128219.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23892.65 Da        Isoelectric Point: 6.9614

>NTDB_id=264156 DW289_RS24090 WP_000611335.1 4713545..4714201(-) (letA) [Escherichia coli strain ST2350 isolate Es_ST2350_SE1_NDM_03_2018]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=264156 DW289_RS24090 WP_000611335.1 4713545..4714201(-) (letA) [Escherichia coli strain ST2350 isolate Es_ST2350_SE1_NDM_03_2018]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGACAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-115)

Bacterial regulatory proteins, luxR family (GerE)

(149-204)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3Z2T8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

51.208

94.954

0.486
  letA Legionella pneumophila strain ERS1305867

51.208

94.954

0.486