Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/blpH   Type   Regulator
Locus tag   DV131_RS05615 Genome accession   NZ_CP031246
Coordinates   1030036..1031376 (+) Length   446 a.a.
NCBI ID   WP_050213946.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain M26368     
Function   phosphorylation of ComE; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1025036..1036376
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  DV131_RS11300 - 1025214..1025453 (-) 240 WP_001813906.1 hypothetical protein -
  DV131_RS05580 - 1025615..1025902 (-) 288 WP_000777760.1 hypothetical protein -
  DV131_RS05585 - 1025912..1026322 (-) 411 WP_001278301.1 HIT family protein -
  DV131_RS05590 pptA 1026390..1027121 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  DV131_RS05595 pptB 1027118..1028167 (+) 1050 WP_050213819.1 ABC transporter permease Regulator
  DV131_RS05600 - 1028335..1028664 (-) 330 WP_000132572.1 hypothetical protein -
  DV131_RS05605 - 1028942..1029280 (+) 339 WP_000876676.1 LytTR family DNA-binding domain-containing protein -
  DV131_RS05610 comE/blpR 1029285..1030022 (+) 738 WP_001219147.1 response regulator transcription factor Regulator
  DV131_RS05615 comD/blpH 1030036..1031376 (+) 1341 WP_050213946.1 sensor histidine kinase Regulator
  DV131_RS05620 blpC 1031418..1031573 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  DV131_RS05625 - 1031630..1032991 (-) 1362 WP_050213945.1 bacteriocin secretion accessory protein -
  DV131_RS05630 blpA 1033002..1035127 (-) 2126 Protein_1021 peptide cleavage/export ABC transporter BlpA -
  DV131_RS05635 blpM 1035407..1035661 (+) 255 WP_054382973.1 two-peptide bacteriocin subunit BlpM -
  DV131_RS05640 blpN 1035677..1035880 (+) 204 WP_001099490.1 two-peptide bacteriocin subunit BlpN -
  DV131_RS05650 cipB 1036124..1036273 (+) 150 WP_001809846.1 bacteriocin-like peptide BlpO Regulator

Sequence

Protein


Download         Length: 446 a.a.        Molecular weight: 51684.41 Da        Isoelectric Point: 5.3698

>NTDB_id=263160 DV131_RS05615 WP_050213946.1 1030036..1031376(+) (comD/blpH) [Streptococcus pneumoniae strain M26368]
MNIAWILLYALVINGLEIVIFFKVDGIGLTFDRIFKAFLLKFLLGIIFTTFQFLAVSKYLSYFIEPLFGIGLSFLLLRGL
PKKILIFYGLFPMILVELFYRGVSYFVLPFLGQGIVDGDGNPIFLLIMIFVCFIVLVFLKWLDYDFTRLRREFLDTGFQK
SLTKINWAMGAYYLVMQSLSYLEYEQGIQSTTVRHLILVFYLLFFMGGIKKLDTYLKEKLQEELNQEQTLRYRDMERYSR
HIEELYKEIRSFRHDYTNLLTSLRLGIEEEDMEQIKEIYDSILRDSSQKLQDNKYDLGRLVNIRDRALKSLLAGKFIKAR
EKNIVFNVEVPEEIQVEGMSLLDFLTIVSILCDNAIEASAEASQPHVSIAFLKNGAQETFIIENSIKEEGIDISEIFSFG
ASSKGEERGVGLYTVMKIVESHPNTNLNTTCQNQVFRQVLTVIHAE

Nucleotide


Download         Length: 1341 bp        

>NTDB_id=263160 DV131_RS05615 WP_050213946.1 1030036..1031376(+) (comD/blpH) [Streptococcus pneumoniae strain M26368]
ATGAACATTGCTTGGATATTGTTGTATGCACTTGTTATTAATGGACTAGAAATTGTCATTTTCTTTAAAGTAGATGGAAT
TGGTCTCACTTTCGATAGAATTTTTAAGGCCTTTCTTCTGAAATTTCTTCTAGGGATCATTTTTACGACTTTTCAATTTT
TGGCTGTAAGTAAATATTTGTCCTATTTTATAGAACCTTTGTTCGGTATAGGTCTATCTTTCTTATTGTTAAGAGGGCTT
CCTAAAAAAATCCTTATTTTTTATGGTCTCTTCCCAATGATATTAGTAGAGCTCTTTTACAGAGGTGTTTCCTATTTTGT
GCTTCCATTTTTGGGGCAAGGAATTGTAGATGGGGATGGCAATCCTATCTTTTTATTGATTATGATATTCGTTTGCTTCA
TAGTTTTAGTCTTTTTGAAATGGTTAGACTATGATTTCACTAGATTGAGAAGGGAGTTTCTAGATACAGGTTTTCAAAAG
TCTCTTACTAAGATTAACTGGGCAATGGGGGCTTATTATCTAGTGATGCAAAGTCTATCTTACCTTGAATATGAACAAGG
TATTCAATCAACGACTGTTCGCCATCTCATCCTAGTGTTTTACCTACTCTTTTTTATGGGGGGTATCAAGAAATTGGATA
CCTATTTGAAGGAAAAACTTCAGGAGGAACTGAACCAAGAGCAGACCTTGCGCTACAGAGATATGGAACGCTATAGTCGG
CATATAGAGGAACTTTACAAGGAAATTCGGAGTTTTCGCCATGACTACACTAACCTCTTAACCAGCTTACGTTTGGGCAT
TGAAGAGGAGGATATGGAGCAGATAAAAGAGATCTACGACTCGATCTTAAGGGATTCCAGTCAGAAATTGCAGGACAATA
AATATGACCTGGGCAGATTGGTGAATATTCGTGACCGTGCCCTCAAGAGTCTCCTAGCTGGAAAATTTATAAAAGCTAGA
GAAAAGAACATTGTCTTTAATGTTGAAGTTCCTGAGGAGATTCAGGTTGAGGGGATGAGCCTACTTGATTTTCTAACCAT
TGTGTCTATCCTTTGTGACAATGCTATTGAAGCTAGTGCAGAGGCCAGTCAACCTCATGTTTCAATCGCCTTTTTAAAAA
ATGGAGCACAGGAGACTTTTATCATTGAAAACTCCATCAAAGAAGAGGGCATCGATATTTCTGAAATCTTCTCCTTTGGA
GCAAGTTCTAAAGGGGAGGAGAGAGGAGTTGGTCTCTATACCGTTATGAAAATTGTGGAAAGTCATCCCAATACCAATCT
AAATACTACCTGCCAAAATCAAGTCTTTCGTCAGGTACTTACTGTGATACATGCAGAATGA

Domains

Predicted by InterProScan.

GHKL domain (HATPase_c_5)

(340-440)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/blpH Streptococcus mutans UA159

42.037

85.874

0.361