Detailed information NTG0263042

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: DV119_RS05675
• Genome accession: NZ_CP031245
• Coordinates: 1027871..1028608 (+)
• Length: 245 a.a.
• NCBI ID: WP_050221200.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain M16808
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 1022871..1033608

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
DV119_RS05645	dnaJ	1023116..1024252 (+)	1137	WP_050073039.1	molecular chaperone DnaJ	-
DV119_RS05650	-	1024632..1024919 (-)	288	WP_000777760.1	hypothetical protein	-
DV119_RS05655	-	1024929..1025339 (-)	411	WP_001278301.1	HIT family protein	-
DV119_RS05660	pptA	1025407..1026138 (+)	732	WP_050221198.1	ABC transporter ATP-binding protein	Regulator
DV119_RS05665	pptB	1026135..1027184 (+)	1050	WP_050221199.1	ABC transporter permease	Regulator
DV119_RS05670	-	1027246..1027575 (-)	330	WP_000132585.1	hypothetical protein	-
DV119_RS05675	comE/blpR	1027871..1028608 (+)	738	WP_050221200.1	response regulator transcription factor	Regulator
DV119_RS05680	-	1028622..1029971 (+)	1350	WP_050221201.1	sensor histidine kinase	-
DV119_RS12160	-	1030205..1030396 (+)	192	WP_376738204.1	hypothetical protein	-
DV119_RS11510	-	1030597..1030761 (+)	165	WP_049511538.1	hypothetical protein	-
DV119_RS05695	-	1030758..1031162 (+)	405	WP_050221203.1	hypothetical protein	-
DV119_RS12165	-	1031433..1031709 (+)	277	Protein_1026	immunity protein	-
DV119_RS05710	-	1031792..1032175 (+)	384	WP_050221205.1	hypothetical protein	-
DV119_RS05715	-	1032240..1032929 (+)	690	WP_050221206.1	CPBP family intramembrane glutamic endopeptidase	-
DV119_RS05720	blpZ	1032971..1033219 (+)	249	WP_050221207.1	immunity protein BlpZ	-

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28828.99 Da
• Isoelectric Point: 6.1688

>NTDB_id=263042 DV119_RS05675 WP_050221200.1 1027871..1028608(+) (comE/blpR) [Streptococcus pneumoniae strain M16808]
MRIFVLEDDFSQQTRIETTIEKLLKEHQIVPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCMIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=263042 DV119_RS05675 WP_050221200.1 1027871..1028608(+) (comE/blpR) [Streptococcus pneumoniae strain M16808]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAAGAACA
TCAGATCGTTCCCAGCTCTTTTGAAGTTTTTGGTAAGCCAGACCAGCTGCTGGCAGAGGTGCATGAGAAGGGAGCTCATC
AGCTATTCTTTTTGGACATTGAGATTCGAAACGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATCCGGGATCGGGAT
CCTTATGCCTTGATAGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCTGCTCTAGA
CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTTCTCTATGCCAATAGTCAAGATA
GTAAAAGTTTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT
CTTGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTAGTTCGTTTGGATA
AGAAAGAAAAACTTCTTTACTTTCCCAATGGTGGAAGCTGTATGATAGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCT
ATCAATAACTTACATTGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.144	99.184	0.547
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	39.669	98.776	0.392
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363