Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   MGAS9429_RS03725 Genome accession   NC_008021
Coordinates   731590..732819 (+) Length   409 a.a.
NCBI ID   WP_002990162.1    Uniprot ID   Q1JM77
Organism   Streptococcus pyogenes MGAS9429     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 726590..737819
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS9429_RS03700 (MGAS9429_Spy0742) - 727206..728483 (-) 1278 WP_002990172.1 hydroxymethylglutaryl-CoA reductase, degradative -
  MGAS9429_RS03705 (MGAS9429_Spy0743) - 728470..729645 (-) 1176 WP_002990170.1 hydroxymethylglutaryl-CoA synthase -
  MGAS9429_RS03710 (MGAS9429_Spy0744) - 729854..730693 (+) 840 WP_002990167.1 thymidylate synthase -
  MGAS9429_RS03715 (MGAS9429_Spy0745) - 730773..731270 (+) 498 WP_002984955.1 dihydrofolate reductase -
  MGAS9429_RS09235 (MGAS9429_Spy0746) - 731290..731460 (+) 171 WP_002990165.1 hypothetical protein -
  MGAS9429_RS03725 (MGAS9429_Spy0747) clpX 731590..732819 (+) 1230 WP_002990162.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  MGAS9429_RS03730 (MGAS9429_Spy0748) yihA 732829..733428 (+) 600 WP_002990160.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  MGAS9429_RS03735 (MGAS9429_Spy0749) - 733576..734319 (+) 744 WP_002984942.1 hypothetical protein -
  MGAS9429_RS03740 (MGAS9429_Spy0750) - 734377..736476 (-) 2100 WP_002990158.1 AAA family ATPase -
  MGAS9429_RS03745 (MGAS9429_Spy0751) rpiA 736854..737537 (+) 684 WP_002990155.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 45036.57 Da        Isoelectric Point: 4.6616

>NTDB_id=25850 MGAS9429_RS03725 WP_002990162.1 731590..732819(+) (clpX) [Streptococcus pyogenes MGAS9429]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELSEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLKTSDLIRI
LTEPRNALVKQYQALLSYDGVELEFDKAALEAIATKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=25850 MGAS9429_RS03725 WP_002990162.1 731590..732819(+) (clpX) [Streptococcus pyogenes MGAS9429]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGTCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTTAAAACATCAGATTTGATTCGAATC
TTAACAGAGCCAAGGAATGCTCTTGTCAAGCAATATCAGGCCCTTCTTTCCTATGATGGGGTTGAATTAGAATTTGATAA
AGCAGCTCTTGAAGCTATCGCAACTAAAGCGATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATTGAAGAAA
CAATGCTTGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-391)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q1JM77

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

88.753

100

0.888
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.603

98.044

0.575

Multiple sequence alignment