Detailed information NTG0025683

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: MGAS9429_RS08725
• Genome accession: NC_008021
• Coordinates: 1772432..1774987 (-)
• Length: 851 a.a.
• NCBI ID: WP_002991365.1
• Uniprot ID: Q1JJH0
• Organism: Streptococcus pyogenes MGAS9429
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1767432..1779987

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS9429_RS08705 (MGAS9429_Spy1812)	-	1767922..1768482 (-)	561	WP_002991358.1	DNA-3-methyladenine glycosylase I	-
MGAS9429_RS08710 (MGAS9429_Spy1813)	ruvA	1768492..1769088 (-)	597	WP_002991359.1	Holliday junction branch migration protein RuvA	Machinery gene
MGAS9429_RS08715 (MGAS9429_Spy1814)	-	1769090..1770310 (-)	1221	WP_002991361.1	MDR family MFS transporter	-
MGAS9429_RS08720 (MGAS9429_Spy1815)	hexB	1770321..1772303 (-)	1983	WP_002991363.1	DNA mismatch repair endonuclease MutL	Machinery gene
MGAS9429_RS08725 (MGAS9429_Spy1816)	hexA	1772432..1774987 (-)	2556	WP_002991365.1	DNA mismatch repair protein MutS	Machinery gene
MGAS9429_RS10080	-	1774974..1775330 (-)	357	Protein_1686	YlbF family regulator	-
MGAS9429_RS08730 (MGAS9429_Spy1818)	argR	1775327..1775764 (-)	438	WP_002982171.1	arginine repressor	-
MGAS9429_RS08735 (MGAS9429_Spy1819)	argS	1776055..1777746 (+)	1692	WP_002991367.1	arginine--tRNA ligase	-
MGAS9429_RS08740 (MGAS9429_Spy1820)	-	1777834..1778142 (+)	309	WP_002991370.1	bacteriocin immunity protein	-
MGAS9429_RS08745 (MGAS9429_Spy1821)	-	1778169..1779041 (-)	873	WP_002982164.1	YitT family protein	-
MGAS9429_RS08750 (MGAS9429_Spy1822)	-	1779084..1779962 (-)	879	WP_002991372.1	YitT family protein	-

Sequence

Protein

• Length: 851 a.a.
• Molecular weight: 95594.10 Da
• Isoelectric Point: 4.9138

>NTDB_id=25683 MGAS9429_RS08725 WP_002991365.1 1772432..1774987(-) (hexA) [Streptococcus pyogenes MGAS9429]
MTKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGYTLAQVPYIKAILESFDSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRTGFDERLDHYRKVMREGTGWIADIEAKERQESGINNLKIDYNKKDGYYFHVTNSNLSLVPEHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKTLATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIMSVPPQV
ESSSAVRQGQLSLFGDDEKAHEIRQALEAIDVMNMTPFQAMTTLYELKKLL

Nucleotide

• Length: 2556 bp

>NTDB_id=25683 MGAS9429_RS08725 WP_002991365.1 1772432..1774987(-) (hexA) [Streptococcus pyogenes MGAS9429]
ATGACAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCCATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTATCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCC
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGAAGTCTCTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGCAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGTATACCTTAGCCCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTGACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGCAGTATTATTCGTACTGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTGAT
GCGAGAAGGAACAGGTTGGATTGCGGATATTGAGGCCAAAGAGCGTCAAGAAAGTGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGAATTCAAATCTTAGCTTAGTTCCCGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAACTTTGGCAACGGTGGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATTCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCCGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGATCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGATTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTTGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATGTCAGTCCCTCCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGATGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGTTTCAAGCAATGACAACTCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

• MutS domain III (MutS_III) (256-546)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

• MutS domain V (MutS_V) (599-785)

3D structure

• AlphaFold DB: Q1JJH0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	71.563	100	0.716
mutS	Pseudomonas stutzeri strain ATCC 17587	37.298	100	0.38