Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   MGAS9429_RS06450 Genome accession   NC_008021
Coordinates   1292811..1293452 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes MGAS9429     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1287811..1298452
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MGAS9429_RS06425 (MGAS9429_Spy1322) comFA/cflA 1287898..1289223 (-) 1326 WP_002988971.1 DEAD/DEAH box helicase Machinery gene
  MGAS9429_RS06430 (MGAS9429_Spy1323) - 1289278..1289910 (+) 633 WP_002988970.1 YigZ family protein -
  MGAS9429_RS06435 (MGAS9429_Spy1324) cysK 1290038..1290979 (+) 942 WP_002988967.1 cysteine synthase A -
  MGAS9429_RS06440 (MGAS9429_Spy1325) - 1290997..1291374 (-) 378 WP_002983674.1 S1 RNA-binding domain-containing protein -
  MGAS9429_RS06445 (MGAS9429_Spy1326) - 1291374..1292774 (-) 1401 WP_002983672.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  MGAS9429_RS06450 (MGAS9429_Spy1327) vraR 1292811..1293452 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  MGAS9429_RS06455 (MGAS9429_Spy1328) - 1293445..1294449 (-) 1005 WP_002983669.1 sensor histidine kinase -
  MGAS9429_RS06460 (MGAS9429_Spy1329) liaF 1294446..1295138 (-) 693 WP_002988964.1 cell wall-active antibiotics response protein LiaF -
  MGAS9429_RS06465 (MGAS9429_Spy1330) pknB 1295261..1297159 (-) 1899 WP_002988962.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  MGAS9429_RS06470 (MGAS9429_Spy1331) - 1297156..1297896 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=25656 MGAS9429_RS06450 WP_002983671.1 1292811..1293452(-) (vraR) [Streptococcus pyogenes MGAS9429]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=25656 MGAS9429_RS06450 WP_002983671.1 1292811..1293452(-) (vraR) [Streptococcus pyogenes MGAS9429]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCCTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAGGTGGACAAAA
AAATTAAAGCGCATGACCAACACCCTGATTTGCATGAAGAGCTAACCGCGCGCGAGTATGATATTTTACATCTTTTAGCT
AAAGGGTATGATAATCAAACTATAGCGGATGAACTTTTCATCTCCTTGAAAACCGTTAAAACGCATGTATCTAATATTCT
TGCTAAGCTAGAAGTTGATGACCGAACTCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment