Detailed information NTG0251053

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CRN64_RS11990
• Genome accession: NZ_CP023970
• Coordinates: 2511960..2513003 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain FDAARGOS_381
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2506960..2518003

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CRN64_RS11965 (CRN64_11965)	-	2507251..2508612 (-)	1362	WP_037540479.1	FAD-dependent oxidoreductase	-
CRN64_RS11970 (CRN64_11970)	-	2508746..2509726 (-)	981	WP_002492696.1	aromatic acid exporter family protein	-
CRN64_RS11975 (CRN64_11975)	map	2509970..2510725 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
CRN64_RS11980 (CRN64_11980)	-	2510851..2511237 (+)	387	WP_002477960.1	hypothetical protein	-
CRN64_RS11985 (CRN64_11985)	liaF	2511262..2511963 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
CRN64_RS11990 (CRN64_11990)	vraS	2511960..2513003 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
CRN64_RS11995 (CRN64_11995)	vraR	2512993..2513622 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
CRN64_RS12000 (CRN64_12000)	-	2513795..2515024 (-)	1230	WP_002492699.1	YihY/virulence factor BrkB family protein	-
CRN64_RS12005 (CRN64_12005)	-	2515227..2515511 (-)	285	WP_002461330.1	YtxH domain-containing protein	-
CRN64_RS12010 (CRN64_12010)	-	2515518..2515982 (-)	465	WP_002492719.1	low molecular weight protein-tyrosine-phosphatase	-
CRN64_RS12015 (CRN64_12015)	-	2516146..2516331 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
CRN64_RS12020 (CRN64_12020)	-	2516344..2517582 (+)	1239	WP_002461326.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=251053 CRN64_RS11990 WP_002461334.1 2511960..2513003(+) (vraS) [Staphylococcus lugdunensis strain FDAARGOS_381]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=251053 CRN64_RS11990 WP_002461334.1 2511960..2513003(+) (vraS) [Staphylococcus lugdunensis strain FDAARGOS_381]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911