Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   M28_RS01595 Genome accession   NC_007296
Coordinates   294673..295359 (+) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes MGAS6180     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 289673..300359
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  M28_RS01570 (M28_Spy0269) ktrB 289815..291191 (-) 1377 WP_032459750.1 potassium uptake transporter channel subunit KtrB -
  M28_RS01575 (M28_Spy0270) rsmG 291276..291989 (-) 714 WP_011054198.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  M28_RS01580 (M28_Spy0271) - 292139..292696 (+) 558 WP_002985956.1 LemA family protein -
  M28_RS01585 (M28_Spy0272) htpX 292743..293639 (+) 897 WP_011284515.1 zinc metalloprotease HtpX -
  M28_RS01590 (M28_Spy0273) - 293873..294406 (+) 534 WP_011054200.1 YceD family protein -
  M28_RS01595 (M28_Spy0274) covR 294673..295359 (+) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  M28_RS01600 (M28_Spy0275) covS 295365..296867 (+) 1503 WP_011284516.1 two-component system sensor histidine kinase CovS -
  M28_RS01605 (M28_Spy0276) nrdR 297082..297576 (+) 495 WP_002985941.1 transcriptional regulator NrdR -
  M28_RS01610 (M28_Spy0277) - 297560..298735 (+) 1176 WP_002991019.1 replication initiation and membrane attachment family protein -
  M28_RS01615 (M28_Spy0278) dnaI 298736..299638 (+) 903 WP_011284517.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=24476 M28_RS01595 WP_002991052.1 294673..295359(+) (covR) [Streptococcus pyogenes MGAS6180]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=24476 M28_RS01595 WP_002991052.1 294673..295359(+) (covR) [Streptococcus pyogenes MGAS6180]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
CGAAGTCATTGTTGAGGTCAATGGTCGTGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACGTATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGCATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAATATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425

Multiple sequence alignment