Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   A6J73_RS04570 Genome accession   NZ_CP023011
Coordinates   997230..998516 (-) Length   428 a.a.
NCBI ID   WP_010737045.1    Uniprot ID   A0A2A4DST9
Organism   Enterococcus hirae strain FDAARGOS_234     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 992230..1003516
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A6J73_RS04545 (A6J73_04555) - 993271..993624 (-) 354 WP_002317104.1 PepSY domain-containing protein -
  A6J73_RS04550 (A6J73_04560) pepA 993823..994902 (+) 1080 WP_010720947.1 glutamyl aminopeptidase -
  A6J73_RS04555 (A6J73_04565) - 995440..995760 (+) 321 WP_002317106.1 thioredoxin family protein -
  A6J73_RS04560 (A6J73_04570) - 995790..996257 (+) 468 WP_002317107.1 universal stress protein -
  A6J73_RS04565 (A6J73_04575) ytpR 996567..997172 (+) 606 WP_010737044.1 YtpR family tRNA-binding protein -
  A6J73_RS04570 (A6J73_04580) htrA 997230..998516 (-) 1287 WP_010737045.1 S1C family serine protease Regulator
  A6J73_RS04575 (A6J73_04585) rlmH 998969..999448 (+) 480 WP_002317110.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  A6J73_RS04580 (A6J73_04590) - 999605..1000516 (+) 912 WP_192574429.1 EcsC family protein -
  A6J73_RS04585 (A6J73_04595) - 1000816..1002408 (+) 1593 WP_095454151.1 type I restriction-modification system subunit M -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44581.68 Da        Isoelectric Point: 4.7976

>NTDB_id=244065 A6J73_RS04570 WP_010737045.1 997230..998516(-) (htrA) [Enterococcus hirae strain FDAARGOS_234]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTK
VKAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVN
INAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITM
VDLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYR
GKEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=244065 A6J73_RS04570 WP_010737045.1 997230..998516(-) (htrA) [Enterococcus hirae strain FDAARGOS_234]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAAAATGTCAAAGTCAATGTCGATTCAGATATTACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGGCAACTGTTTGGTCA
ACAACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTA
ATTCCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGGCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAA
GTCAAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGT
TGCTTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCGGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATG
CCAACTCTGTGACTTCGGGGATTATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAAT
ATCAATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGTCAAGTGAT
CGGGATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCC
CAAGTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATG
GTTGACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGT
TACCAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTG
ATGTTTCTTCTGGTGTAGAATTACAATCTGTCTTGTATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGC
GGAAAAGAAAAGAAAACAACAACAATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGTCAATCAGAGAACTCTGG
TAACTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(124-269)

PDZ domain (PDZ_2)

(314-411)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2A4DST9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

54.545

92.523

0.505
  htrA Streptococcus gordonii str. Challis substr. CH1

53.35

94.159

0.502
  htrA Streptococcus pneumoniae Rx1

58.457

78.738

0.46
  htrA Streptococcus pneumoniae D39

58.457

78.738

0.46
  htrA Streptococcus pneumoniae R6

58.457

78.738

0.46
  htrA Streptococcus pneumoniae TIGR4

58.457

78.738

0.46
  htrA Streptococcus mitis NCTC 12261

57.567

78.738

0.453

Multiple sequence alignment