Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   CGP94_RS10045 Genome accession   NZ_CP022898
Coordinates   1973356..1973985 (-) Length   209 a.a.
NCBI ID   WP_000153530.1    Uniprot ID   D9IFM7
Organism   Staphylococcus aureus strain 422     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1968356..1978985
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CGP94_RS10015 (CGP94_01847) - 1968776..1969306 (-) 531 WP_000184381.1 acyl-CoA thioesterase -
  CGP94_RS10020 (CGP94_01848) - 1969396..1970652 (-) 1257 WP_078103411.1 aminopeptidase -
  CGP94_RS10025 (CGP94_01849) - 1970655..1970855 (-) 201 WP_000180462.1 DUF1128 family protein -
  CGP94_RS10030 (CGP94_01850) - 1971002..1971466 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  CGP94_RS10035 (CGP94_01851) - 1971473..1971748 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  CGP94_RS10040 (CGP94_01852) - 1972026..1973243 (+) 1218 WP_000037088.1 YihY/virulence factor BrkB family protein -
  CGP94_RS10045 (CGP94_01853) vraR 1973356..1973985 (-) 630 WP_000153530.1 two-component system response regulator VraR Regulator
  CGP94_RS10050 (CGP94_01854) vraS 1973975..1975018 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  CGP94_RS10055 (CGP94_01855) liaF 1975015..1975716 (-) 702 WP_106459782.1 cell wall-active antibiotics response protein LiaF -
  CGP94_RS10060 (CGP94_01856) - 1975731..1976117 (-) 387 WP_001110179.1 hypothetical protein -
  CGP94_RS10065 (CGP94_01857) map 1976334..1977092 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  CGP94_RS14695 - 1977161..1977616 (-) 456 WP_141724549.1 hypothetical protein -
  CGP94_RS10085 (CGP94_01858) - 1977789..1978775 (+) 987 WP_000999713.1 aromatic acid exporter family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23545.29 Da        Isoelectric Point: 5.3889

>NTDB_id=242958 CGP94_RS10045 WP_000153530.1 1973356..1973985(-) (vraR) [Staphylococcus aureus strain 422]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMDDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=242958 CGP94_RS10045 WP_000153530.1 1973356..1973985(-) (vraR) [Staphylococcus aureus strain 422]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGATGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTAATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D9IFM7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment