Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexA   Type   Machinery gene
Locus tag   SK637_RS00820 Genome accession   NZ_CP028415
Coordinates   174764..177298 (+) Length   844 a.a.
NCBI ID   WP_033687999.1    Uniprot ID   -
Organism   Streptococcus mitis strain SK637     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 169764..182298
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SK637_RS00800 (SK637_00157) - 170352..171368 (-) 1017 WP_033687996.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
  SK637_RS00805 (SK637_00158) - 171536..171781 (-) 246 WP_000084861.1 hypothetical protein -
  SK637_RS00810 (SK637_00159) argS 172440..174131 (-) 1692 WP_033687997.1 arginine--tRNA ligase -
  SK637_RS00815 (SK637_00160) argR 174267..174713 (+) 447 WP_001231476.1 arginine repressor -
  SK637_RS00820 (SK637_00161) hexA 174764..177298 (+) 2535 WP_033687999.1 DNA mismatch repair protein MutS Machinery gene
  SK637_RS00825 (SK637_00162) patA 177444..179150 (+) 1707 WP_033688000.1 multidrug efflux ABC transporter subunit PatA -
  SK637_RS00830 (SK637_00163) rcrQ 179152..180918 (+) 1767 WP_033688001.1 multidrug efflux ABC transporter subunit PatB Regulator
  SK637_RS10020 (SK637_00164) - 181041..181187 (+) 147 WP_023941542.1 hypothetical protein -
  SK637_RS00835 (SK637_00166) - 181208..181896 (+) 689 Protein_157 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -

Sequence

Protein


Download         Length: 844 a.a.        Molecular weight: 94763.15 Da        Isoelectric Point: 4.8531

>NTDB_id=241184 SK637_RS00820 WP_033687999.1 174764..177298(+) (hexA) [Streptococcus mitis strain SK637]
MATEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLI
EQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVAIDREGNQFGLAYMDLVTGDFYVTGLLDFTL
VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKEGFEDLHLLDSRLVAVEQAASSKLLQYVHRTQMRELNHLKP
VIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFF
ERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPALAYLIEQLDGIPELESLISAAIAP
EAPHVITDGGIIRTGFDETLDKYRRVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKS
TLKNSERFGTEELARIEGDMLEAREKSANLEYEIFMRIREEVSKYIQRLQTLAQGIATVDVLQSLAVVAETQHLIRPEFG
DDSQIDIQKGRHAVIEKVMGAQTYIPNTIQMAEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAYLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHEL
TSLESSLEHLVNVHVATLEQDGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTGSPVPMRQTSA
VTEQISLFDTAEEHPILAELAKLDIYNMTPMQAMNVLVELKQKL

Nucleotide


Download         Length: 2535 bp        

>NTDB_id=241184 SK637_RS00820 WP_033687999.1 174764..177298(+) (hexA) [Streptococcus mitis strain SK637]
ATGGCGACAGAAAAGCTATCACCCGGCATGCAACAGTATGTGGATATTAAAAAGCAATATCCAGATGCGTTTTTGCTCTT
TCGGATGGGTGATTTTTATGAATTATTTTATGAGGATGCGGTCAATGCTGCGCAGATTCTGGAAATTTCCTTAACGAGTC
GCAACAAGAATGCCGACAATCCGATTCCTATGGCGGGTGTTCCCTATCATTCTGCCCAACAGTACATTGATGTCTTGATT
GAGCAGGGTTATAAGGTGGCTATCGCAGAGCAGATGGAAGATCCTAAACAAGCAGTTGGGGTTGTGAAACGAGAAGTTGT
TCAGGTTATTACGCCAGGGACAGTGGTTGATAGTAGTAAGCCAGATAGTCAGAACAACTTCTTGGTTGCAATAGATCGTG
AGGGCAATCAATTTGGCCTAGCTTACATGGATCTAGTGACGGGTGACTTTTATGTGACAGGCCTTTTGGATTTCACGCTG
GTTTGTGGAGAAATCCGCAATCTCAAGGCGCGCGAAGTGGTGTTGGGTTATGACTTGTCTGAGGAAGAAGAACAAATCCT
TAGTCGTCAGATGAATCTGGTACTTTCCTATGAAAAAGAAGGCTTTGAAGACCTTCATTTACTGGATTCACGATTAGTAG
CTGTGGAGCAAGCGGCATCTAGTAAGTTGCTCCAGTATGTCCATCGAACCCAGATGAGGGAATTGAACCACCTCAAGCCT
GTTATCCGCTATGAAATCAAAGATTTCTTGCAGATGGATTATGCGACCAAGGCTAGTCTGGATTTGGTTGAAAATGCCCG
TTCAGGCAAGAAGCAAGGCAGTCTTTTCTGGCTTTTGGATGAAACCAAGACGGCTATGGGGATGCGTCTTTTGCGTTCTT
GGATTCATCGCCCCTTGATTGATAAGGAGCGAATCGTCCAACGTCAAGAGGTGGTGCAGGTCTTTCTTGACCACTTCTTT
GAGCGCAGTGATTTGACAGACAGTCTCAAGGGTGTTTATGACATTGAGCGCTTGGCTAGTCGTGTTTCTTTTGGCAAAAC
CAATCCCAAGGATCTCTTGCAGTTGGCGACTACCTTGTCTAGTGTGCCAAGAATTCGTGCGATTTTAGAAGGAATGGAGC
AACCTGCTCTAGCTTATCTCATCGAACAACTGGATGGAATCCCTGAGTTAGAGAGTTTGATTAGCGCAGCGATTGCTCCT
GAAGCCCCTCATGTGATTACAGATGGGGGAATTATCCGAACTGGATTTGATGAGACTTTAGACAAGTACCGTCGCGTGCT
CAGAGAAGGGACTAGCTGGATTGCTGAGATTGAAGCAAAGGAGCGAGAAAACTCTGGTATCAGTACGCTCAAGATTGACT
ACAATAAAAAGGATGGCTACTATTTCCATGTGACCAATTCTCAACTGGGGAATGTGCCAGCCCACTTTTTCCGCAAGTCG
ACGCTGAAAAACTCAGAACGTTTTGGAACGGAAGAATTAGCCCGTATCGAGGGCGATATGCTGGAGGCGCGTGAGAAGTC
AGCTAACCTAGAGTACGAAATTTTTATGCGCATTCGTGAAGAGGTCAGCAAGTACATCCAGCGTTTACAAACTCTAGCCC
AAGGTATTGCAACAGTTGATGTCTTGCAAAGTCTGGCGGTTGTGGCTGAAACCCAGCATTTGATTCGACCTGAGTTTGGT
GACGATTCACAAATCGATATCCAGAAAGGGCGCCATGCTGTCATTGAAAAAGTCATGGGGGCTCAGACCTATATTCCCAA
TACGATTCAGATGGCAGAAGATACCAGTATTCAACTGATTACAGGGCCCAACATGAGTGGGAAGTCAACCTACATGCGTC
AGTTAGCCATGACGGCGGTTATGGCTCAGTTGGGTTCTTATGTGCCAGCAGAAAGCGCCTATTTACCGATTTTTGATGCG
ATTTTTACCCGCATTGGAGCAGCAGATGACTTGGTTTCAGGTCAATCAACCTTTATGGTGGAGATGATGGAGGCAAACAA
TGCCATTTCGCATGCGACCAAGAACTCTCTCATTCTCTTTGATGAATTGGGACGGGGAACTGCAACTTATGACGGGATGG
CTCTTGCTCAGTCCATCATCGAATACATCCATGAGCACATCGGAGCCAAGACCCTCTTTGCGACCCACTACCATGAGTTG
ACTAGTCTGGAGTCTAGCTTGGAACACTTGGTCAATGTCCACGTGGCAACTTTGGAGCAGGATGGGCAGGTTACCTTCCT
TCACAAGATTGAACCAGGTCCAGCTGATAAATCCTATGGTATCCATGTTGCCAAGATTGCTGGCTTACCAGCAGACCTTT
TAGCAAGGGCAGATAAGATTTTGACTCAGTTAGAGAATCAAGGTACAGGAAGTCCAGTTCCTATGAGGCAAACAAGTGCT
GTCACTGAACAGATTTCACTCTTTGATACGGCAGAAGAACATCCTATCCTAGCAGAATTAGCTAAACTGGATATTTACAA
TATGACACCTATGCAGGCTATGAATGTCTTGGTCGAGTTAAAACAAAAATTATAA

Domains

Predicted by InterProScan.

MutS domain V (MutS_V)

(599-785)

MutS domain I (MutS_I)

(8-118)

MutS domain II (MutS_II)

(126-239)

MutS domain III (MutS_III)

(256-546)

MutS family domain IV (MutS_IV)

(415-505)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexA Streptococcus pneumoniae R6

97.156

100

0.972
  mutS Pseudomonas stutzeri strain ATCC 17587

36.491

100

0.37