Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   C5P47_RS08635 Genome accession   NZ_CP028140
Coordinates   1711050..1713032 (-) Length   660 a.a.
NCBI ID   WP_110410884.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NGAS979     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1706050..1718032
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C5P47_RS08610 (C5P47_08595) recA 1706086..1707222 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  C5P47_RS08615 (C5P47_08600) cinA 1707311..1708582 (-) 1272 WP_032464622.1 competence/damage-inducible protein A Machinery gene
  C5P47_RS08620 (C5P47_08605) - 1708651..1709211 (-) 561 WP_011018314.1 DNA-3-methyladenine glycosylase I -
  C5P47_RS08625 (C5P47_08610) ruvA 1709221..1709817 (-) 597 WP_002982180.1 Holliday junction branch migration protein RuvA Machinery gene
  C5P47_RS08630 (C5P47_08615) - 1709819..1711039 (-) 1221 WP_032461237.1 MFS transporter -
  C5P47_RS08635 (C5P47_08620) hexB 1711050..1713032 (-) 1983 WP_110410884.1 DNA mismatch repair endonuclease MutL Machinery gene
  C5P47_RS08640 (C5P47_08625) - 1713127..1714272 (-) 1146 WP_110410860.1 site-specific integrase -
  C5P47_RS09355 (C5P47_08630) - 1714600..1714743 (+) 144 WP_110410861.1 putative holin-like toxin -
  C5P47_RS08650 (C5P47_08635) - 1715627..1716274 (-) 648 WP_011529101.1 helix-turn-helix transcriptional regulator -
  C5P47_RS08655 (C5P47_08640) - 1716443..1716637 (+) 195 Protein_1607 helix-turn-helix transcriptional regulator -
  C5P47_RS08660 (C5P47_08645) - 1716651..1717265 (+) 615 WP_181876669.1 Bro-N domain-containing protein -
  C5P47_RS08665 (C5P47_08650) - 1717292..1717534 (+) 243 WP_032463078.1 hypothetical protein -
  C5P47_RS08670 (C5P47_08655) - 1717781..1717984 (+) 204 WP_110410863.1 hypothetical protein -

Sequence

Protein


Download         Length: 660 a.a.        Molecular weight: 74243.78 Da        Isoelectric Point: 5.8700

>NTDB_id=238381 C5P47_RS08635 WP_110410884.1 1711050..1713032(-) (hexB) [Streptococcus pyogenes strain NGAS979]
MTNIIELPEVLANQIAAGEVVERPASVVKELVENAIDAKSSQITVEIEESGLKMIQVTDNGEGMSHEDLPLSLRRHATSK
IKSQSDLFRIRTLGFRGEALPSVASISKITIKTATKEVTHGSLLIATGGEIETLEAISTPTGTKIKVENLFYNTPARLKY
MKSLQAELAHIVDVVNRLSLAHPEVAFTLISDGRQLTQTSGTGDLRQAIAGIYGLNTTKKMLAISNADLDFEVSGYVSLP
ELTRANRNYMTILVNGRYIKNFLLNRAILDGYGSKLMVGRFPIVVIDIQIDPYLADVNVHPTKQEVRISKERELMALIST
AISESLKEQDLIPDALENLAKSSTRHFSKPEQTQLPLQSRGLYYDPQKNDFFVKESAVSEKIPETDFYSGAVDNSVKVEK
AELLPHSEEVIGPSSVKHASRPQNTFTETDHPNLDLKNRQKLSQMLTRLENEGQSVFPELDYFGQMHGTYLFAQGKDGLF
IIDQHAAQERVKYEYYRDKIGDVDSSLQQLLVPYLFEFSGSDFINLQEKMALLNEVGIFLEVYGHNTFILREHPIWMKEE
EIASGVYEMCDMLLLTNEVSIKTYRAELAIMMSCKRSIKANHSLDDYSARNLLLQLAQCQNPYNCPHGRPVLINFSKADM
EKMFRRIQENHTSLRELGKY

Nucleotide


Download         Length: 1983 bp        

>NTDB_id=238381 C5P47_RS08635 WP_110410884.1 1711050..1713032(-) (hexB) [Streptococcus pyogenes strain NGAS979]
ATGACAAACATTATTGAATTACCGGAAGTTCTCGCCAACCAAATTGCAGCTGGTGAAGTTGTAGAAAGGCCAGCGAGTGT
TGTCAAGGAATTGGTTGAGAATGCTATTGATGCTAAAAGTAGCCAGATTACCGTTGAAATTGAAGAGTCTGGCCTTAAGA
TGATACAGGTTACAGACAACGGTGAGGGAATGTCTCATGAAGATTTACCTTTAAGTCTGCGTCGCCACGCTACTAGTAAA
ATTAAGAGTCAGAGTGATTTGTTTAGAATTAGAACACTTGGCTTCCGTGGAGAGGCTTTACCGTCTGTTGCCTCTATCAG
TAAAATCACGATAAAAACAGCAACAAAAGAAGTCACTCACGGTTCTCTTCTTATAGCTACTGGTGGGGAAATTGAGACAC
TTGAAGCGATCTCAACTCCTACTGGAACCAAAATTAAGGTTGAAAACCTTTTTTACAACACGCCTGCTCGTCTCAAATAC
ATGAAAAGTTTACAGGCAGAATTAGCTCACATTGTAGATGTGGTCAACCGGTTGAGTTTGGCACATCCAGAAGTTGCTTT
CACACTGATTAGTGATGGTCGCCAATTAACTCAGACATCAGGAACTGGCGATTTACGCCAAGCAATTGCAGGGATTTATG
GTTTGAATACTACCAAAAAAATGCTGGCTATCTCTAATGCTGATTTGGATTTTGAAGTTTCCGGCTATGTTAGCTTGCCA
GAGTTGACACGCGCCAACCGTAATTACATGACGATTTTGGTTAATGGGCGTTACATCAAGAATTTCTTGCTTAATCGAGC
AATTCTTGATGGTTACGGTTCTAAGCTCATGGTTGGACGTTTCCCAATTGTTGTGATTGATATTCAGATTGATCCCTATT
TGGCCGATGTCAATGTTCATCCCACAAAACAAGAGGTTCGTATTTCAAAAGAGCGTGAATTAATGGCTTTAATTAGCACG
GCTATTTCAGAGAGTCTTAAGGAACAAGATTTGATTCCAGATGCTCTGGAAAACTTAGCCAAATCAAGCACACGACATTT
CTCTAAACCAGAGCAAACACAACTTCCTTTACAGTCTAGGGGGCTTTATTATGATCCTCAAAAGAATGACTTTTTTGTCA
AAGAGTCGGCTGTCTCGGAAAAAATACCTGAAACTGATTTTTATTCCGGCGCTGTTGACAACAGTGTAAAGGTTGAAAAA
GCAGAGCTGTTACCCCACTCAGAAGAAGTTATAGGACCTTCTTCGGTTAAACACGCAAGTCGTCCCCAGAATACCTTTAC
CGAGACTGATCATCCTAATCTTGACTTAAAAAACAGACAAAAGTTATCTCAAATGCTAACCCGTTTGGAAAATGAAGGGC
AATCAGTGTTTCCCGAATTGGATTATTTTGGTCAGATGCATGGGACTTATCTCTTTGCTCAAGGTAAAGATGGCTTATTT
ATTATCGATCAGCATGCTGCTCAAGAGCGGGTTAAATACGAATATTATCGTGATAAGATTGGCGACGTTGACAGTAGTTT
ACAGCAGCTATTGGTACCCTATTTGTTTGAGTTTTCTGGTTCTGATTTCATTAACTTACAGGAGAAAATGGCACTCTTAA
ATGAAGTTGGTATCTTCTTAGAAGTTTATGGGCACAATACTTTCATTTTGAGGGAGCATCCTATCTGGATGAAAGAAGAA
GAGATTGCATCTGGTGTCTATGAAATGTGTGACATGTTGCTTCTAACCAATGAGGTATCTATCAAAACTTACCGAGCAGA
GTTAGCTATTATGATGAGTTGTAAACGATCTATCAAGGCAAATCATAGCTTGGATGATTATTCAGCAAGAAATCTGCTAC
TGCAATTAGCCCAATGTCAAAATCCTTATAACTGCCCTCATGGTAGACCCGTATTGATTAATTTTAGTAAGGCAGATATG
GAAAAAATGTTCCGTCGAATTCAAGAAAATCACACTAGCCTGCGAGAGCTAGGAAAATATTAG

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(462-604)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-118)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

66.867

100

0.673

Multiple sequence alignment