Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   C5P47_RS06560 Genome accession   NZ_CP028140
Coordinates   1279607..1280248 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain NGAS979     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1274607..1285248
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C5P47_RS06535 (C5P47_06520) comFA/cflA 1274693..1276018 (-) 1326 WP_110410823.1 DEAD/DEAH box helicase Machinery gene
  C5P47_RS06540 (C5P47_06525) - 1276074..1276706 (+) 633 WP_002983676.1 YigZ family protein -
  C5P47_RS06545 (C5P47_06530) cysK 1276834..1277775 (+) 942 WP_011528853.1 cysteine synthase A -
  C5P47_RS06550 (C5P47_06535) - 1277793..1278170 (-) 378 WP_032464495.1 S1 RNA-binding domain-containing protein -
  C5P47_RS06555 (C5P47_06540) - 1278170..1279570 (-) 1401 WP_063629207.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  C5P47_RS06560 (C5P47_06545) vraR 1279607..1280248 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  C5P47_RS06565 (C5P47_06550) - 1280241..1281245 (-) 1005 WP_002991890.1 sensor histidine kinase -
  C5P47_RS06570 (C5P47_06555) liaF 1281242..1281934 (-) 693 WP_011888670.1 cell wall-active antibiotics response protein LiaF -
  C5P47_RS06575 (C5P47_06560) pknB 1282057..1283955 (-) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  C5P47_RS06580 (C5P47_06565) - 1283952..1284692 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=238356 C5P47_RS06560 WP_002983671.1 1279607..1280248(-) (vraR) [Streptococcus pyogenes strain NGAS979]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=238356 C5P47_RS06560 WP_002983671.1 1279607..1280248(-) (vraR) [Streptococcus pyogenes strain NGAS979]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385