Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   I3W_RS12670 Genome accession   NZ_CP028122
Coordinates   2186984..2187640 (-) Length   218 a.a.
NCBI ID   WP_000611335.1    Uniprot ID   Q3Z2T8
Organism   Escherichia coli O43 str. RM10042     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2181984..2192640
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I3W_RS12640 (I3W_12640) yecA 2183235..2183900 (-) 666 WP_000847902.1 UPF0149 family protein YecA -
  I3W_RS12660 (I3W_12660) pgsA 2184550..2185098 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  I3W_RS12665 (I3W_12665) uvrC 2185155..2186987 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  I3W_RS12670 (I3W_12670) letA 2186984..2187640 (-) 657 WP_000611335.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  I3W_RS28590 - 2187782..2187853 (+) 72 Protein_2116 transcriptional regulator -
  I3W_RS27740 yecU 2187936..2188112 (+) 177 WP_000590347.1 protein YecU -
  I3W_RS12675 (I3W_12675) yecF 2188099..2188323 (+) 225 WP_000106474.1 DUF2594 family protein YecF -
  I3W_RS12680 (I3W_12680) sdiA 2188390..2189112 (-) 723 WP_001154279.1 transcriptional regulator SdiA -
  I3W_RS12685 (I3W_12685) tcyN 2189342..2190094 (-) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  I3W_RS12690 (I3W_12690) tcyL 2190091..2190759 (-) 669 WP_001158220.1 cystine ABC transporter permease -
  I3W_RS12695 (I3W_12695) dcyD 2190774..2191760 (-) 987 WP_001128219.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23892.65 Da        Isoelectric Point: 6.9614

>NTDB_id=237972 I3W_RS12670 WP_000611335.1 2186984..2187640(-) (letA) [Escherichia coli O43 str. RM10042]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=237972 I3W_RS12670 WP_000611335.1 2186984..2187640(-) (letA) [Escherichia coli O43 str. RM10042]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGACAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-115)

Bacterial regulatory proteins, luxR family (GerE)

(149-204)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3Z2T8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

51.208

94.954

0.486
  letA Legionella pneumophila strain ERS1305867

51.208

94.954

0.486

Multiple sequence alignment