Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   I3S_RS23540 Genome accession   NZ_CP028110
Coordinates   4472959..4473615 (+) Length   218 a.a.
NCBI ID   WP_000611335.1    Uniprot ID   Q3Z2T8
Organism   Escherichia coli O121 str. RM8352     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 4467959..4478615
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I3S_RS23510 (I3S_23495) dcyD 4468839..4469825 (+) 987 WP_001128215.1 D-cysteine desulfhydrase -
  I3S_RS23515 (I3S_23500) tcyL 4469840..4470508 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  I3S_RS23520 (I3S_23505) tcyN 4470505..4471257 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  I3S_RS23525 (I3S_23510) sdiA 4471487..4472209 (+) 723 WP_001154267.1 transcriptional regulator SdiA -
  I3S_RS23530 (I3S_23515) yecF 4472276..4472500 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  I3S_RS29455 yecU 4472487..4472663 (-) 177 WP_000590344.1 protein YecU -
  I3S_RS30645 (I3S_23520) - 4472701..4472817 (-) 117 WP_001302039.1 hypothetical protein -
  I3S_RS23540 (I3S_23525) letA 4472959..4473615 (+) 657 WP_000611335.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  I3S_RS23545 (I3S_23530) uvrC 4473612..4475444 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  I3S_RS23550 (I3S_23535) pgsA 4475501..4476049 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  I3S_RS23570 (I3S_23555) - 4477044..4477325 (+) 282 WP_071529678.1 hypothetical protein -
  I3S_RS23575 (I3S_23560) - 4477515..4477655 (-) 141 WP_000078920.1 Hok/Gef family protein -
  I3S_RS23585 (I3S_23570) - 4477846..4478106 (-) 261 WP_000488108.1 ogr/Delta-like zinc finger family protein -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23892.65 Da        Isoelectric Point: 6.9614

>NTDB_id=237696 I3S_RS23540 WP_000611335.1 4472959..4473615(+) (letA) [Escherichia coli O121 str. RM8352]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=237696 I3S_RS23540 WP_000611335.1 4472959..4473615(+) (letA) [Escherichia coli O121 str. RM8352]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGACAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCTAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-115)

Bacterial regulatory proteins, luxR family (GerE)

(149-204)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3Z2T8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

51.208

94.954

0.486
  letA Legionella pneumophila strain ERS1305867

51.208

94.954

0.486

Multiple sequence alignment