Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SE071780_RS08325 Genome accession   NZ_CP021972
Coordinates   1728349..1729098 (-) Length   249 a.a.
NCBI ID   WP_012679946.1    Uniprot ID   C0M6E8
Organism   Streptococcus equi subsp. equi strain ATCC 39506     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1723349..1734098
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SE071780_RS08310 (SE071780_01740) - 1725304..1726662 (+) 1359 WP_012679944.1 bacteriocin secretion accessory protein -
  SE071780_RS08315 (SE071780_01741) - 1726762..1726893 (+) 132 WP_012677513.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  SE071780_RS08320 - 1727015..1727845 (-) 831 WP_230197368.1 GHKL domain-containing protein -
  SE071780_RS08325 (SE071780_01743) comE/blpR 1728349..1729098 (-) 750 WP_012679946.1 LytTR family DNA-binding domain-containing protein Regulator
  SE071780_RS08330 (SE071780_01744) - 1729725..1729928 (-) 204 WP_012679947.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SE071780_RS08335 (SE071780_01745) - 1729945..1730202 (-) 258 WP_012679948.1 Blp family class II bacteriocin -
  SE071780_RS08340 (SE071780_01746) rlmD 1730523..1731890 (-) 1368 WP_012679949.1 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD -
  SE071780_RS08345 (SE071780_01747) - 1731887..1732855 (-) 969 WP_012679950.1 DNA-binding protein -
  SE071780_RS08350 (SE071780_01748) prx 1732995..1733177 (-) 183 WP_160203833.1 Paratox Regulator
  SE071780_RS08355 (SE071780_01749) - 1733373..1733888 (-) 516 WP_023077389.1 hypothetical protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29257.72 Da        Isoelectric Point: 8.7559

>NTDB_id=235440 SE071780_RS08325 WP_012679946.1 1728349..1729098(-) (comE/blpR) [Streptococcus equi subsp. equi strain ATCC 39506]
MRVVILEDDMIQQRYLEKLIKELEVKHQLLFQGLDCFGRPHQLLSAIKKNCGQQLFFLDIEIKNENKKGLEVARQIRQIN
PDAMIVFVTTHSEFMPLAFQYQVSALDYIDKELPQTEFVQRVETALLYAVRQNSETIAESAFYFTSRYAQVQVPFNDILY
IETSSRAHRVNLYTKKERMQFTGTLTDILKQESRFLQCHRSFLINHRNVVRVDKIERVVYFRNGSSCLIARSKMNSVLTT
IENLHRGDN

Nucleotide


Download         Length: 750 bp        

>NTDB_id=235440 SE071780_RS08325 WP_012679946.1 1728349..1729098(-) (comE/blpR) [Streptococcus equi subsp. equi strain ATCC 39506]
GTGAGAGTAGTTATTTTAGAAGATGATATGATTCAGCAGAGATATTTAGAAAAGCTCATTAAAGAGCTTGAGGTTAAGCA
CCAGCTATTATTTCAAGGACTTGACTGTTTTGGAAGGCCTCATCAGCTATTAAGTGCTATCAAGAAGAACTGTGGTCAGC
AGCTATTCTTTTTAGATATTGAGATAAAAAATGAGAACAAAAAAGGGCTTGAGGTTGCTAGGCAAATTCGTCAGATAAAT
CCAGATGCGATGATTGTTTTTGTAACGACTCACTCGGAATTTATGCCCTTGGCTTTTCAGTATCAGGTATCTGCTTTGGA
CTATATCGATAAAGAGCTGCCTCAAACTGAGTTTGTTCAACGGGTAGAGACTGCTTTATTATATGCTGTGCGGCAAAATA
GTGAAACGATAGCGGAAAGTGCTTTTTATTTTACATCTCGTTATGCTCAGGTACAGGTGCCTTTTAATGATATCCTGTAT
ATTGAGACATCGTCACGAGCGCATCGTGTCAATTTGTATACAAAAAAGGAGAGAATGCAATTTACGGGGACTTTGACGGA
TATTTTGAAGCAAGAGTCTCGTTTTTTGCAATGTCATCGTTCTTTTTTGATTAATCATAGGAATGTCGTTAGGGTAGATA
AGATTGAGCGAGTGGTTTATTTTCGAAATGGCTCTAGCTGCTTAATTGCTCGTAGTAAAATGAACAGTGTTTTAACAACA
ATTGAGAACCTACATAGAGGAGATAATTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-237)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB C0M6E8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.209

100

0.522
  comE/comE1 Streptococcus equinus JB1

40.167

95.984

0.386

Multiple sequence alignment