Detailed information NTG0234356

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: C6W71_RS16905
• Genome accession: NZ_CP027452
• Coordinates: 3277665..3280238 (+)
• Length: 857 a.a.
• NCBI ID: WP_001317994.1
• Uniprot ID: A0A0H3EN94
• Organism: Escherichia coli strain 2014C-3338
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 3272665..3285238

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
C6W71_RS16870	pheL	3272751..3272798 (-)	48	WP_001386991.1	pheA operon leader peptide PheL	-
C6W71_RS16875	raiA	3272902..3273243 (-)	342	WP_000178456.1	ribosome-associated translation inhibitor RaiA	-
C6W71_RS16885	insG	3273504..3274851 (-)	1348	Protein_3103	IS4-like element IS4 family transposase	-
C6W71_RS16890	comL	3274955..3275692 (-)	738	WP_000197684.1	outer membrane protein assembly factor BamD	Machinery gene
C6W71_RS16895	rluD	3275827..3276807 (+)	981	WP_000079108.1	23S rRNA pseudouridine(1911/1915/1917) synthase RluD	-
C6W71_RS16900	yfiH	3276804..3277535 (+)	732	WP_000040126.1	purine nucleoside phosphorylase YfiH	-
C6W71_RS16905	clpC	3277665..3280238 (+)	2574	WP_001317994.1	ATP-dependent chaperone ClpB	Regulator

Sequence

Protein

• Length: 857 a.a.
• Molecular weight: 95599.05 Da
• Isoelectric Point: 5.1899

>NTDB_id=234356 C6W71_RS16905 WP_001317994.1 3277665..3280238(+) (clpC) [Escherichia coli strain 2014C-3338]
MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVSPLLTSAGINAGQLRTDINQALNRLPQVEGTGGD
VQPSQDLVRVLNLCDKLAQKRGDNFISSELFVLAALESRGTLADILKAAGATTANITQAIEQMRGGESVNDQGAEDQRQA
LKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL
DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR
QYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASS
IRMQIDSKPEELDRLDRRIIQLKLEQQALMKESDEASKKRLDMLNEELSDKERQYSELEEEWKAEKASLSGTQTIKAELE
QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQLEGKTMRLLRNKVTDAEIAEVLARWTGIPVSRMMESEREKLL
RMEQELHHRVIGQNEAVDAVSNAIRRSRAGLADPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDEAMIRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQERFGELDYAHMKELVLGVVSHNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLKRLYKRLEERGYEIHISDEAL
KLLSENGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKVIRLEVNEDRIVAVQ

Nucleotide

• Length: 2574 bp

>NTDB_id=234356 C6W71_RS16905 WP_001317994.1 3277665..3280238(+) (clpC) [Escherichia coli strain 2014C-3338]
ATGCGTCTGGATCGTCTTACTAATAAATTCCAGCTTGCTCTTGCCGATGCCCAATCACTTGCACTCGGGCACGACAACCA
ATTCATCGAACCACTTCATTTAATGAGCGCCCTGCTGAATCAGGAAGGGGGTTCGGTTAGTCCTTTATTAACATCCGCTG
GCATTAATGCTGGCCAGTTGCGCACAGATATCAATCAGGCATTAAATCGTTTACCGCAGGTTGAAGGTACTGGTGGTGAT
GTCCAGCCATCACAGGATCTGGTGCGCGTTCTTAATCTTTGCGACAAGCTGGCGCAAAAACGTGGTGATAACTTTATCTC
GTCAGAACTGTTCGTTCTGGCGGCACTTGAGTCTCGCGGCACGCTGGCCGACATCCTGAAAGCAGCAGGGGCGACCACCG
CCAACATTACTCAAGCGATTGAACAAATGCGTGGAGGTGAAAGCGTGAACGATCAAGGTGCTGAAGACCAACGTCAGGCT
TTGAAAAAATATACCATCGACCTTACAGAACGAGCCGAACAGGGCAAACTCGATCCGGTGATTGGTCGTGATGAAGAAAT
TCGCCGTACCATTCAGGTGCTGCAACGTCGTACTAAAAATAACCCGGTACTGATTGGTGAACCAGGCGTCGGTAAAACTG
CCATCGTTGAAGGTCTGGCGCAGCGTATCATCAACGGCGAAGTGCCGGAAGGGTTGAAAGGCCGCCGCGTACTGGCGCTG
GATATGGGCGCGCTGGTGGCTGGGGCGAAATATCGCGGTGAGTTTGAAGAACGTTTAAAAGGCGTACTTAACGATCTTGC
TAAACAGGAAGGCAACGTCATCCTGTTTATCGACGAATTACATACCATGGTCGGCGCGGGTAAAGCCGATGGCGCAATGG
ACGCCGGAAACATGCTGAAACCGGCGCTGGCGCGTGGTGAATTGCACTGCGTAGGTGCCACGACGCTTGACGAATATCGC
CAGTACATCGAAAAAGATGCTGCGCTGGAACGTCGTTTCCAGAAAGTGTTTGTTGCCGAGCCTTCTGTTGAAGATACCAT
TGCGATTCTGCGTGGCCTGAAAGAACGTTACGAATTGCACCACCATGTGCAAATTACTGACCCGGCAATTGTTGCAGCGG
CGACGTTGTCTCATCGCTACATTGCTGACCGTCAGCTGCCGGATAAAGCCATCGACCTGATCGATGAAGCAGCATCCAGC
ATTCGTATGCAGATTGACTCAAAACCAGAAGAACTCGACCGACTCGATCGCCGTATCATCCAGCTTAAACTGGAACAACA
GGCGTTAATGAAAGAGTCTGATGAAGCCAGTAAAAAACGCCTGGATATGCTCAACGAAGAACTGAGCGACAAAGAACGTC
AGTACTCCGAGTTAGAAGAAGAGTGGAAAGCAGAGAAAGCATCGCTTTCTGGTACGCAGACCATTAAAGCGGAACTGGAA
CAAGCGAAAATCGCTATTGAACAGGCTCGCCGTGTGGGGGACCTGGCGCGGATGTCTGAACTGCAATACGGCAAAATCCC
GGAACTGGAAAAGCAACTGGAAGCCGCAACGCAGCTCGAAGGCAAAACTATGCGTCTGTTGCGTAATAAAGTGACCGATG
CCGAAATTGCTGAAGTGCTGGCGCGTTGGACGGGGATTCCGGTTTCTCGCATGATGGAAAGCGAGCGCGAAAAACTGCTG
CGTATGGAGCAAGAACTGCACCATCGCGTTATTGGTCAGAACGAAGCGGTTGATGCGGTATCTAACGCTATTCGTCGTAG
CCGTGCGGGGCTGGCGGATCCAAATCGCCCGATTGGTTCATTCCTGTTCCTCGGCCCAACCGGTGTGGGGAAAACTGAGC
TTTGTAAGGCGCTGGCGAACTTTATGTTTGATAGCGACGAGGCGATGATCCGTATCGATATGTCCGAGTTTATGGAGAAA
CACTCTGTGTCTCGTCTGGTTGGTGCGCCTCCGGGATATGTCGGTTATGAAGAAGGTGGCTACCTGACCGAAGCTGTGCG
TCGTCGTCCGTATTCCGTCATCCTGCTGGATGAAGTGGAAAAAGCGCATCCGGATGTCTTCAACATTCTGTTGCAGGTAC
TGGATGATGGGCGTCTGACTGACGGGCAGGGGAGAACGGTCGACTTCCGTAATACGGTTGTCATTATGACCTCTAACCTC
GGTTCCGATTTGATTCAGGAACGCTTCGGTGAACTGGATTATGCGCACATGAAAGAGCTGGTGCTCGGTGTGGTAAGCCA
TAACTTCCGTCCGGAATTCATTAACCGTATCGATGAAGTGGTGGTCTTCCATCCGCTGGGTGAACAGCACATTGCGTCGA
TTGCGCAGATTCAGTTGAAACGTCTGTACAAACGTCTGGAAGAACGTGGTTATGAAATCCACATTTCTGACGAGGCGCTG
AAACTGCTGAGCGAGAACGGTTACGATCCGGTCTATGGTGCACGTCCGCTGAAACGTGCTATCCAGCAGCAGATCGAAAA
CCCGCTGGCACAGCAAATACTGTCTGGTGAATTGGTTCCGGGTAAAGTTATTCGCCTGGAAGTTAATGAAGACCGGATTG
TCGCCGTCCAGTAA

Domains

Predicted by InterProScan.

• AAA lid domain (AAA_lid_9) (342-443)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (94-145)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• AAA domain (Cdc48 subfamily) (AAA_2) (596-760)

• ATPase family associated with various cellular activities (AAA) (AAA) (203-337)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (766-845)

3D structure

• AlphaFold DB: A0A0H3EN94

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	47.931	100	0.487
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.691	100	0.429
clpE	Streptococcus pneumoniae Rx1	48.012	79.23	0.38
clpE	Streptococcus pneumoniae D39	48.012	79.23	0.38
clpE	Streptococcus pneumoniae R6	48.012	79.23	0.38
clpE	Streptococcus pneumoniae TIGR4	48.012	79.23	0.38
clpC	Lactococcus lactis subsp. cremoris KW2	46.522	80.513	0.375
clpE	Streptococcus mutans UA159	46.637	79.813	0.372