Detailed information NTG0023111

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: GBS_RS10670
• Genome accession: NC_004368
• Coordinates: 2126898..2129474 (-)
• Length: 858 a.a.
• NCBI ID: WP_001118377.1
• Uniprot ID: Q8DWW1
• Organism: Streptococcus agalactiae NEM316
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 2121898..2134474

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GBS_RS10645 (gbs2049)	-	2122009..2122560 (-)	552	WP_000817341.1	DNA-3-methyladenine glycosylase I	-
GBS_RS10650 (gbs2050)	ruvA	2122583..2123173 (-)	591	WP_000272487.1	Holliday junction branch migration protein RuvA	Machinery gene
GBS_RS10655 (gbs2051)	-	2123175..2124407 (-)	1233	WP_000657476.1	MFS transporter	-
GBS_RS10660 (gbs2052)	hexB	2124439..2126412 (-)	1974	WP_000034617.1	DNA mismatch repair endonuclease MutL	Machinery gene
GBS_RS10665 (gbs2053)	-	2126638..2126841 (+)	204	WP_000191849.1	cold-shock protein	-
GBS_RS10670 (gbs2054)	hexA	2126898..2129474 (-)	2577	WP_001118377.1	DNA mismatch repair protein MutS	Machinery gene
GBS_RS10675 (gbs2055)	argR	2129531..2129977 (-)	447	WP_001060644.1	arginine repressor	-
GBS_RS10680 (gbs2056)	argS	2130190..2131881 (+)	1692	WP_000379867.1	arginine--tRNA ligase	-
GBS_RS10685 (gbs2057)	-	2131969..2132277 (+)	309	WP_001138859.1	bacteriocin immunity protein	-
GBS_RS10690 (gbs2058)	-	2132304..2133176 (-)	873	WP_000915474.1	YitT family protein	-
GBS_RS10695 (gbs2059)	-	2133284..2134228 (-)	945	WP_000857770.1	YitT family protein	-

Sequence

Protein

• Length: 858 a.a.
• Molecular weight: 97078.70 Da
• Isoelectric Point: 4.8140

>NTDB_id=23111 GBS_RS10670 WP_001118377.1 2126898..2129474(-) (hexA) [Streptococcus agalactiae NEM316]
MAKPTISPGMQQYLDIKENYPDAFLLFRMGDFYELFYDDAVKAAQILEISLTSRNKNAEKPIPMAGVPYHSAQQYIDVLV
ELGYKVAIAEQMEDPKKAVGVVKREVVQVVTPGTVVESTKPDSANNFLVAIDSQDQQTFGLAYMDVSTGEFQATLLTDFE
SVRSEILNLKAREIVVGYQLTDEKNHLLTKQMNLLLSYEDERLNDIHLIDEQLTDLEISAAEKLLQYVHRTQKRELSHLQ
KVVHYEIKDYLQMSYATKNSLDLLENARTSKKHGSLYWLLDETKTAMGTRMLRTWIDRPLVSMNRIKERQDIIQVFLDYF
FERNDLTESLKGVYDIERLASRVSFGKANPKDLLQLGQTLSQIPRIKMILQSFNQPELDIIVNKIDTMPELESLINTAIA
PEAQATITEGNIIKSGFDKQLDNYRTVMREGTGWIADIEAKERAASGIGTLKIDYNKKDGYYFHVTNSNLSLVPEHFFRK
ATLKNSERYGTAELAKIEGEMLEAREQSSNLEYDIFMRVRAQVESYIKRLQELAKTIATVDVLQSLAVVAENYHYVRPKF
NDQHQIKIKNGRHATVEKVMGVQEYIPNSIYFDSQTDIQLITGPNMSGKSTYMRQLALTVIMAQMGGFVSADEVDLPVFD
AIFTRIGAADDLISGQSTFMVEMMEANQAVKRASDKSLILFDELGRGTATYDGMALAQSIIEYIHDRVRAKTMFATHYHE
LTDLSEQLTRLVNVHVATLERDGEVTFLHKIESGPADKSYGIHVAKIAGLPIDLLDRATDILSQLEADAVQLIVSPSQEA
VTADLNEELDSEKQQGQLSLFEEPSNAGRVIEELEAIDIMNLTPMQAMNAIFDLKKLL

Nucleotide

• Length: 2577 bp

>NTDB_id=23111 GBS_RS10670 WP_001118377.1 2126898..2129474(-) (hexA) [Streptococcus agalactiae NEM316]
ATGGCCAAGCCAACGATATCACCGGGAATGCAACAGTATCTGGATATAAAAGAGAATTATCCAGATGCTTTTTTGCTTTT
TAGAATGGGTGATTTTTATGAATTATTTTATGATGATGCGGTAAAAGCAGCACAAATCCTGGAAATTAGCTTGACTAGTC
GAAATAAGAACGCAGAAAAGCCAATCCCAATGGCAGGAGTTCCCTATCACTCAGCTCAACAGTATATTGACGTTTTAGTT
GAATTAGGTTACAAAGTAGCCATTGCTGAGCAGATGGAAGATCCTAAAAAAGCTGTGGGAGTGGTCAAGCGTGAGGTAGT
GCAAGTTGTTACCCCAGGAACGGTTGTGGAGTCAACGAAGCCGGATAGTGCTAATAATTTCTTAGTAGCGATTGATTCGC
AAGATCAACAAACATTTGGTCTAGCATATATGGATGTCTCAACTGGAGAGTTTCAGGCAACCCTTTTAACAGATTTTGAG
TCCGTCCGTAGTGAAATACTAAATTTAAAAGCTCGTGAGATTGTAGTAGGATATCAATTGACGGACGAAAAAAATCACCT
ACTGACGAAGCAGATGAACTTGCTTTTATCATACGAAGACGAACGACTTAATGATATTCATTTGATTGATGAGCAGTTAA
CTGATTTGGAAATATCTGCTGCGGAAAAACTTTTACAATATGTGCATAGAACACAAAAGCGTGAACTTAGTCATTTACAG
AAAGTAGTTCATTATGAAATAAAGGACTATTTACAAATGTCATATGCAACGAAAAATAGTCTAGATTTACTGGAGAATGC
TAGAACAAGCAAGAAGCATGGAAGTCTTTACTGGTTGTTAGATGAGACTAAAACAGCGATGGGAACTCGAATGCTGAGAA
CTTGGATTGACAGGCCTTTGGTAAGTATGAATCGAATCAAGGAACGTCAAGATATTATTCAAGTGTTTCTTGATTATTTT
TTTGAGAGAAACGATCTCACAGAAAGTTTAAAGGGTGTATATGATATTGAACGCCTAGCAAGTCGAGTATCTTTCGGAAA
AGCCAACCCTAAAGATCTATTGCAACTCGGACAGACCTTATCACAAATTCCTCGGATTAAAATGATTTTACAGTCCTTCA
ATCAACCTGAGCTTGACATCATTGTCAACAAAATTGACACTATGCCTGAATTAGAAAGTTTAATTAATACGGCGATAGCC
CCAGAAGCACAGGCTACTATCACTGAGGGAAACATTATCAAGTCTGGATTTGATAAGCAATTGGATAATTATCGAACAGT
GATGCGTGAAGGTACAGGTTGGATTGCTGATATTGAAGCTAAGGAAAGAGCAGCAAGTGGTATCGGTACTCTTAAAATTG
ATTATAATAAAAAAGACGGTTATTACTTCCATGTTACCAATTCCAATTTATCACTAGTACCGGAGCATTTTTTCCGTAAA
GCGACATTAAAAAATTCTGAACGCTATGGAACAGCAGAACTAGCCAAAATTGAAGGTGAAATGCTCGAAGCTCGCGAGCA
ATCTTCAAATTTAGAATATGATATTTTTATGCGTGTTCGTGCCCAAGTAGAATCTTATATTAAACGTCTTCAAGAGTTAG
CAAAGACGATTGCAACCGTTGATGTTCTACAGAGTTTGGCAGTAGTTGCAGAAAATTATCACTATGTTCGTCCCAAATTT
AATGATCAACATCAGATTAAGATTAAGAATGGGCGTCATGCAACTGTTGAAAAAGTGATGGGAGTGCAAGAATATATTCC
CAATAGCATCTATTTTGATAGTCAGACAGATATCCAGTTGATTACAGGACCAAATATGAGTGGTAAGTCGACCTATATGC
GCCAGTTAGCTTTGACAGTTATTATGGCACAAATGGGAGGTTTTGTATCGGCAGACGAAGTTGATTTGCCTGTATTTGAT
GCAATATTTACTAGGATTGGTGCTGCTGACGACTTAATTTCTGGGCAATCAACCTTTATGGTAGAAATGATGGAAGCGAA
TCAAGCTGTAAAACGAGCCAGTGATAAATCTTTGATTCTTTTTGATGAATTAGGTCGAGGGACAGCCACTTATGATGGTA
TGGCATTAGCTCAATCGATTATAGAATATATTCATGACCGTGTTAGGGCAAAAACAATGTTTGCGACTCATTACCATGAG
TTGACAGATTTATCTGAACAGTTGACAAGGCTTGTCAATGTACACGTGGCTACTTTAGAGAGAGATGGAGAAGTTACCTT
CTTACATAAAATTGAATCTGGACCTGCGGATAAGTCTTATGGGATACACGTCGCAAAAATAGCTGGTTTACCAATTGACT
TATTGGATAGGGCAACTGATATTTTATCACAGTTGGAAGCTGATGCAGTACAGTTGATCGTATCGCCCTCCCAAGAAGCT
GTTACTGCTGACTTAAATGAGGAACTAGATTCTGAGAAGCAACAAGGACAATTATCGCTTTTTGAAGAACCTTCAAATGC
AGGTAGGGTTATTGAGGAGTTAGAAGCGATAGATATAATGAATCTAACTCCAATGCAAGCTATGAATGCTATATTTGACT
TAAAGAAATTATTATAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-240)

• MutS family domain IV (MutS_IV) (416-506)

• MutS domain III (MutS_III) (257-547)

• MutS domain V (MutS_V) (600-786)

• MutS domain I (MutS_I) (8-118)

3D structure

• AlphaFold DB: Q8DWW1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	69.114	100	0.691
mutS	Pseudomonas stutzeri strain ATCC 17587	36.519	100	0.374