Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraS   Type   Regulator
Locus tag   CAC37_RS09035 Genome accession   NZ_CP021178
Coordinates   1871744..1872787 (-) Length   347 a.a.
NCBI ID   WP_001017131.1    Uniprot ID   A0A0D1IMN4
Organism   Staphylococcus aureus subsp. aureus ST398 strain 2012-3     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1866744..1877787
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CAC37_RS09005 (CAC37_09370) - 1867165..1868421 (-) 1257 WP_001793428.1 aminopeptidase -
  CAC37_RS09010 (CAC37_09375) - 1868424..1868624 (-) 201 WP_000180460.1 DUF1128 family protein -
  CAC37_RS09015 (CAC37_09380) - 1868771..1869235 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  CAC37_RS09020 (CAC37_09385) - 1869242..1869517 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  CAC37_RS09025 (CAC37_09390) - 1869795..1871012 (+) 1218 WP_000037081.1 YihY/virulence factor BrkB family protein -
  CAC37_RS09030 (CAC37_09395) vraR 1871125..1871754 (-) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  CAC37_RS09035 (CAC37_09400) vraS 1871744..1872787 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  CAC37_RS09040 (CAC37_09405) liaF 1872784..1873485 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  CAC37_RS09045 (CAC37_09410) - 1873500..1873886 (-) 387 WP_096002295.1 hypothetical protein -
  CAC37_RS09050 (CAC37_09415) map 1874103..1874861 (-) 759 WP_000636145.1 type I methionyl aminopeptidase -
  CAC37_RS09055 (CAC37_09425) - 1875389..1876375 (+) 987 WP_000999712.1 FUSC family protein -
  CAC37_RS09060 (CAC37_09430) - 1876564..1876977 (-) 414 WP_025174370.1 hypothetical protein -
  CAC37_RS09065 (CAC37_09435) - 1877006..1877116 (-) 111 WP_014937049.1 hypothetical protein -

Sequence

Protein


Download         Length: 347 a.a.        Molecular weight: 40044.52 Da        Isoelectric Point: 6.0577

>NTDB_id=228959 CAC37_RS09035 WP_001017131.1 1871744..1872787(-) (vraS) [Staphylococcus aureus subsp. aureus ST398 strain 2012-3]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide


Download         Length: 1044 bp        

>NTDB_id=228959 CAC37_RS09035 WP_001017131.1 1871744..1872787(-) (vraS) [Staphylococcus aureus subsp. aureus ST398 strain 2012-3]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(249-340)

Histidine kinase (HisKA_3)

(147-210)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0D1IMN4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraS Staphylococcus aureus N315

100

100

1

Multiple sequence alignment