Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   C4N11_RS01905 Genome accession   NZ_CP026670
Coordinates   350571..351203 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain endophthalmitis isolate 335     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 345571..356203
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  C4N11_RS01880 (C4N11_01880) mvaD 345849..346802 (+) 954 WP_000373457.1 diphosphomevalonate decarboxylase -
  C4N11_RS01885 (C4N11_01885) - 346789..347796 (+) 1008 WP_000562413.1 phosphomevalonate kinase -
  C4N11_RS01890 (C4N11_01890) fni 347780..348790 (+) 1011 WP_000210618.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  C4N11_RS01895 (C4N11_01895) liaF 348867..349565 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  C4N11_RS01900 (C4N11_01900) - 349562..350557 (+) 996 WP_000743674.1 sensor histidine kinase -
  C4N11_RS01905 (C4N11_01905) vraR 350571..351203 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  C4N11_RS12470 - 351279..351973 (+) 695 Protein_359 DNA alkylation repair protein -
  C4N11_RS01925 (C4N11_01925) - 352123..352362 (+) 240 WP_000754501.1 hypothetical protein -
  C4N11_RS01930 (C4N11_01930) cbpG 352443..353264 (+) 822 WP_001100142.1 choline-binding protein CbpG -
  C4N11_RS01935 (C4N11_01935) cbpF 353283..354305 (+) 1023 WP_000765212.1 choline-binding protein CbpF -
  C4N11_RS01940 (C4N11_01940) - 354433..355781 (-) 1349 Protein_363 IS3 family transposase -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=227781 C4N11_RS01905 WP_000698434.1 350571..351203(+) (vraR) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=227781 C4N11_RS01905 WP_000698434.1 350571..351203(+) (vraR) [Streptococcus pneumoniae strain endophthalmitis isolate 335]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGTTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGAATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment