Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   SPYM18_RS07045 Genome accession   NC_003485
Coordinates   1356286..1356927 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes MGAS8232     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1351286..1361927
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYM18_RS07020 (spyM18_1625) comFA/cflA 1351372..1352697 (-) 1326 WP_011018051.1 DEAD/DEAH box helicase Machinery gene
  SPYM18_RS07025 (spyM18_1626) - 1352753..1353385 (+) 633 WP_009880468.1 YigZ family protein -
  SPYM18_RS07030 (spyM18_1627) cysK 1353513..1354454 (+) 942 WP_011018052.1 cysteine synthase A -
  SPYM18_RS07035 (spyM18_1628) - 1354472..1354849 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  SPYM18_RS07040 (spyM18_1629) - 1354849..1356249 (-) 1401 WP_023079685.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  SPYM18_RS07045 (spyM18_1630) vraR 1356286..1356927 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  SPYM18_RS07050 (spyM18_1631) - 1356920..1357924 (-) 1005 WP_002983669.1 sensor histidine kinase -
  SPYM18_RS07055 (spyM18_1632) liaF 1357921..1358613 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  SPYM18_RS07060 (spyM18_1634) pknB 1358736..1360634 (-) 1899 WP_011018054.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  SPYM18_RS07065 (spyM18_1635) - 1360631..1361371 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=22595 SPYM18_RS07045 WP_002983671.1 1356286..1356927(-) (vraR) [Streptococcus pyogenes MGAS8232]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=22595 SPYM18_RS07045 WP_002983671.1 1356286..1356927(-) (vraR) [Streptococcus pyogenes MGAS8232]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAAGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCCTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTCCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCTGGTGCTAAAGGTTACATGTTAAAGAC
TTCTAGTGCAGCCGAAATTCTAAATGCTATTCGGAAAGTTTCAAAAGGTGAATTGGCCATTGAAACAGAGGTGGACAAAA
AAATTAAAGCGCATGACCAACACCCTGATTTGCATGAAGAGCTAACCGCGCGCGAGTATGATATTTTACATCTTTTAGCT
AAAGGGTATGATAATCAAACTATAGCGGATGAACTTTTCATCTCCTTGAAAACCGTTAAAACGCATGTATCTAATATTCT
TGCTAAGCTAGAAGTTGATGACCGAACTCAAGCGGTTGTCTATGCTTTTCGACACCATTTAGTTCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment