Detailed information NTG0022458

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: GBS_RS04110
• Genome accession: NC_004368
• Coordinates: 759747..761096 (+)
• Length: 449 a.a.
• NCBI ID: WP_001065469.1
• Uniprot ID: R4ZB13
• Organism: Streptococcus agalactiae NEM316
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 754747..766096

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
GBS_RS04080 (gbs0736)	-	755289..756107 (+)	819	WP_001222610.1	ParA family protein	-
GBS_RS04085 (gbs0737)	-	756104..756382 (+)	279	WP_000131727.1	hypothetical protein	-
GBS_RS04090 (gbs0738)	-	756395..756778 (+)	384	WP_000323828.1	replication initiator protein A	-
GBS_RS04095 (gbs0739)	-	756783..757094 (+)	312	WP_000583310.1	hypothetical protein	-
GBS_RS04100 (gbs0740)	-	757228..758556 (+)	1329	WP_000151682.1	ISLre2 family transposase	-
GBS_RS04105 (gbs0741)	vicR	759044..759754 (+)	711	WP_000722052.1	response regulator YycF	Regulator
GBS_RS04110 (gbs0742)	vicK	759747..761096 (+)	1350	WP_001065469.1	cell wall metabolism sensor histidine kinase VicK	Regulator
GBS_RS04115 (gbs0743)	vicX	761100..761909 (+)	810	WP_001289499.1	MBL fold metallo-hydrolase	Regulator
GBS_RS04120 (gbs0744)	-	761912..762280 (+)	369	WP_000719384.1	YbaN family protein	-
GBS_RS04125 (gbs0745)	rnc	762456..763142 (+)	687	WP_000661526.1	ribonuclease III	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 51059.13 Da
• Isoelectric Point: 4.8621

>NTDB_id=22458 GBS_RS04110 WP_001065469.1 759747..761096(+) (vicK) [Streptococcus agalactiae NEM316]
MNNSAANIRSFELALLFLLVFVAVYFVYLAVRDFKMSKNIRLLNWKVRDLIAGNYSDSILIQGDADLVELGESLNDLSDV
FRMAHDNLEQEKNRLASILTYMTDGVLATDRSGKIVMINETAQQQFNLAYDEALSMNIVDMLGSGSPYSFQDLVSKTPEV
VLNRRDENGEFVTLRIRFALNRRESGFISGLVAVSHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALNE
EVAPSFIKVSLDETNRMMRMISDLLSLSRIDNEVTHLDVEMTNFTAFMTSILNRFDQIRNQKTVTGKVYEIVRDYPLKSI
WVEIDTDKMTQVIDNILNNAVKYSPDGGKITVNLRTTKTQMILSISDQGLGIPKKDLPLIFDRFYRVDKARSRQQGGTGL
GLSIAKEIVKQHKGFIWAKSEYGKGSTFTIVLPYDKDAVTYEEWEDVED

Nucleotide

• Length: 1350 bp

>NTDB_id=22458 GBS_RS04110 WP_001065469.1 759747..761096(+) (vicK) [Streptococcus agalactiae NEM316]
ATGAATAATAGTGCTGCAAATATTAGGTCGTTTGAGCTAGCCTTACTTTTTTTACTAGTTTTTGTTGCTGTCTATTTTGT
TTATCTAGCGGTTAGAGATTTTAAAATGTCTAAAAATATCCGGCTTTTGAATTGGAAAGTCAGAGATTTGATAGCAGGAA
ATTATTCAGATAGTATTCTAATTCAAGGTGATGCAGATTTGGTAGAATTAGGGGAAAGTCTAAATGATTTATCTGATGTC
TTCCGAATGGCACATGATAACTTAGAACAAGAAAAGAATCGCTTAGCAAGTATCTTAACTTATATGACTGACGGTGTGCT
GGCTACAGATCGTTCAGGAAAAATCGTTATGATTAATGAGACAGCCCAACAGCAGTTCAATCTAGCATATGATGAAGCTT
TATCAATGAATATTGTTGATATGTTAGGGTCGGGAAGTCCATATTCGTTCCAAGATTTAGTCTCTAAAACGCCAGAGGTA
GTTCTTAATAGACGTGATGAAAATGGTGAATTTGTTACCTTACGGATTCGATTTGCTTTGAACCGTCGTGAAAGTGGTTT
TATTTCCGGTTTAGTTGCAGTATCACACGATGCTACTGAGCAAGAGAAAGAAGAGCGTGAAAGAAGACTTTTTGTATCTA
ATGTTTCTCATGAACTTCGTACACCTTTGACATCTGTAAAATCTTATTTAGAAGCTTTAGATGAGGGAGCGCTCAATGAA
GAAGTTGCTCCAAGCTTCATTAAGGTATCTCTAGATGAAACAAATCGTATGATGCGTATGATATCAGATTTATTAAGTTT
ATCGCGCATTGATAATGAAGTAACGCATTTAGATGTTGAAATGACGAATTTTACAGCTTTCATGACCTCAATTTTGAATC
GATTTGACCAGATTAGAAATCAAAAAACAGTCACAGGAAAAGTTTATGAAATTGTCAGAGATTATCCTCTTAAGTCAATT
TGGGTGGAAATTGATACAGATAAAATGACTCAAGTGATTGATAACATTTTAAATAATGCAGTCAAGTATTCACCAGATGG
TGGTAAGATTACAGTTAATCTACGCACAACTAAAACGCAGATGATTTTATCAATATCAGACCAAGGCTTAGGTATTCCCA
AAAAAGATTTACCTCTCATCTTTGATCGTTTTTATCGTGTTGATAAGGCGAGAAGTCGTCAACAGGGTGGGACTGGACTT
GGTTTGTCAATTGCAAAAGAAATTGTTAAGCAGCATAAGGGATTTATTTGGGCTAAGAGTGAGTATGGTAAAGGGTCTAC
TTTTACAATCGTCTTGCCTTATGATAAAGATGCTGTAACTTATGAAGAATGGGAGGACGTTGAAGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (325-435)

• PAS fold (PAS) (94-180)

• His Kinase A (phospho-acceptor) domain (HisKA) (208-272)

3D structure

• AlphaFold DB: R4ZB13

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	74.576	91.982	0.686
micB	Streptococcus pneumoniae Cp1015	67.436	96.437	0.65