Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   SMU_RS02390 Genome accession   NC_004350
Coordinates   467118..468419 (+) Length   433 a.a.
NCBI ID   WP_002263026.1    Uniprot ID   Q8DVJ0
Organism   Streptococcus mutans UA159     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 462118..473419
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMU_RS02370 (SMU.494) - 463268..463936 (+) 669 WP_002263030.1 fructose-6-phosphate aldolase -
  SMU_RS02375 (SMU.495) - 463974..465065 (+) 1092 WP_002263029.1 glycerol dehydrogenase -
  SMU_RS02380 (SMU.496) cysK 465399..466325 (-) 927 WP_002263028.1 cysteine synthase A -
  SMU_RS02385 (SMU.497c) - 466416..467045 (-) 630 WP_002263027.1 YigZ family protein -
  SMU_RS02390 (SMU.498) comFA/cflA 467118..468419 (+) 1302 WP_002263026.1 DEAD/DEAH box helicase Machinery gene
  SMU_RS02395 (SMU.499) - 468416..469081 (+) 666 WP_002263025.1 ComF family protein -
  SMU_RS02400 (SMU.500) raiA 469160..469708 (+) 549 WP_002263024.1 ribosome hibernation-promoting factor, HPF/YfiA family -
  SMU_RS02405 (SMU.501) - 469832..470926 (+) 1095 WP_002273626.1 hypothetical protein -
  SMU_RS02410 (SMU.502) - 470946..472646 (+) 1701 WP_002263022.1 zinc ribbon domain-containing protein -
  SMU_RS02415 (SMU.503c) - 472726..473361 (-) 636 WP_002263021.1 hypothetical protein -

Sequence

Protein


Download         Length: 433 a.a.        Molecular weight: 49469.67 Da        Isoelectric Point: 9.9950

>NTDB_id=22419 SMU_RS02390 WP_002263026.1 467118..468419(+) (comFA/cflA) [Streptococcus mutans UA159]
MENLENYYGRLLTENQMNSDLKKQAKILPAMIKKPHYFICNRCGSQNNLGNALPDGSIYCRACLVFGRLTNRDSLYYFEQ
KPFPKGQVLRWQGQLTPFQQEVSRGLKKSVCHKENMLIHAVTGAGKTEMIYETLASILNQGGAVALASPRIDVCIELYKR
LSRDFSCPISLLYGESEAYERSPLVIATTHQLLKFYRAFDLLIIDEVDAFPFVDNKMLYYAVDHCLKSDGVKVFLTATST
DQLDKQVKQGKLKKLHLARRFHANPLVVPKPIWLNLSLERLQRGKLPRSFLQQIRIQRQTQFPLLIFFPNIEDGLTFAKS
LQTYLPNEKIDFVSSLTTDRLEKVENFRKGNTQILVSTTILERGVTFPCVDVFVMMSNHYLFTKSSLVQIAGRVGRSADR
PDGKLLFFHNGMNRAMKKAIMEIKTMNKKGGFA

Nucleotide


Download         Length: 1302 bp        

>NTDB_id=22419 SMU_RS02390 WP_002263026.1 467118..468419(+) (comFA/cflA) [Streptococcus mutans UA159]
ATGGAGAATTTAGAGAATTATTATGGCCGCCTCTTGACCGAGAATCAAATGAACAGTGATTTGAAAAAGCAAGCTAAAAT
CTTGCCAGCTATGATAAAAAAACCGCATTACTTTATCTGCAATCGTTGCGGCAGTCAGAACAATCTTGGTAATGCTTTGC
CGGATGGATCTATCTACTGTCGAGCTTGTCTTGTCTTTGGACGTCTTACTAACAGGGACAGTCTTTATTATTTTGAGCAA
AAGCCTTTTCCAAAGGGTCAGGTCTTAAGGTGGCAAGGGCAATTAACCCCTTTTCAGCAGGAAGTTTCCCGTGGTTTAAA
AAAGAGTGTTTGCCATAAGGAAAATATGCTTATTCATGCTGTAACAGGTGCAGGCAAAACGGAGATGATTTATGAAACTC
TGGCCAGCATTCTCAATCAAGGGGGTGCGGTTGCACTTGCTAGTCCTCGCATTGATGTCTGCATAGAACTGTATAAACGT
TTAAGTCGTGACTTTTCTTGTCCTATCAGTCTTTTGTATGGAGAGTCAGAAGCTTATGAACGCAGTCCATTAGTGATTGC
AACCACGCATCAACTTTTGAAATTTTACCGAGCTTTTGATTTGTTAATTATTGATGAAGTAGATGCCTTTCCTTTTGTTG
ACAATAAGATGCTCTATTATGCTGTAGATCATTGTCTGAAATCAGATGGTGTCAAAGTATTTTTGACTGCAACTTCGACT
GACCAATTAGACAAACAGGTTAAGCAAGGGAAGCTAAAAAAACTGCATTTAGCCAGACGATTTCATGCCAATCCCTTAGT
TGTTCCCAAGCCAATTTGGTTGAATTTATCTCTTGAAAGATTACAAAGAGGTAAATTACCGCGCTCTTTTTTACAGCAGA
TAAGAATTCAAAGGCAGACTCAATTCCCTCTTTTGATCTTTTTTCCGAATATTGAAGATGGTTTAACCTTTGCTAAATCA
CTGCAAACCTATCTTCCAAATGAGAAAATTGATTTTGTTTCCAGCTTGACAACAGATCGTTTAGAAAAAGTCGAAAATTT
TAGAAAAGGAAACACACAAATTTTGGTTTCAACAACGATTTTAGAGAGGGGAGTCACTTTTCCTTGTGTAGATGTTTTTG
TCATGATGAGCAACCATTATCTGTTCACCAAAAGTTCTCTGGTACAGATTGCTGGTCGTGTGGGACGCTCTGCCGATAGA
CCAGATGGAAAATTACTTTTCTTTCATAATGGAATGAACAGAGCCATGAAAAAGGCCATTATGGAAATCAAGACTATGAA
CAAAAAAGGAGGTTTTGCATGA

Domains

Predicted by InterproScan.

Helicase conserved C-terminal domain (Helicase_C)

(296-397)

Type III restriction enzyme, res subunit (ResIII)

(94-168)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DVJ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae Rx1

59.485

98.614

0.587
  comFA/cflA Streptococcus pneumoniae D39

59.485

98.614

0.587
  comFA/cflA Streptococcus pneumoniae R6

59.485

98.614

0.587
  comFA/cflA Streptococcus pneumoniae TIGR4

59.485

98.614

0.587
  comFA/cflA Streptococcus mitis NCTC 12261

58.782

98.614

0.58
  comFA/cflA Streptococcus mitis SK321

58.782

98.614

0.58
  comFA Lactococcus lactis subsp. cremoris KW2

52.03

90.993

0.473
  comFA Latilactobacillus sakei subsp. sakei 23K

38.928

99.076

0.386

Multiple sequence alignment