Detailed information NTG0223387

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: B4U56_RS04580
• Genome accession: NZ_CP020463
• Coordinates: 932873..933919 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 1457
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 927873..938919

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
B4U56_RS04555 (B4U56_04550)	isaB	929014..929550 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
B4U56_RS04560 (B4U56_04555)	-	929701..930687 (-)	987	WP_001830388.1	FUSC family protein	-
B4U56_RS04565 (B4U56_04560)	map	930861..931616 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
B4U56_RS04570 (B4U56_04565)	-	931774..932160 (+)	387	WP_001830382.1	hypothetical protein	-
B4U56_RS04575 (B4U56_04570)	liaF	932175..932876 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
B4U56_RS04580 (B4U56_04575)	vraS	932873..933919 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
B4U56_RS04585 (B4U56_04580)	vraR	933909..934538 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
B4U56_RS04590 (B4U56_04585)	-	934595..935773 (-)	1179	WP_002485151.1	YihY/virulence factor BrkB family protein	-
B4U56_RS04595 (B4U56_04590)	-	936180..936464 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
B4U56_RS04600 (B4U56_04595)	-	936472..936936 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
B4U56_RS04605 (B4U56_04600)	-	937077..937292 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
B4U56_RS04610 (B4U56_04605)	-	937294..938535 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=223387 B4U56_RS04580 WP_001830374.1 932873..933919(+) (vraS) [Staphylococcus epidermidis strain 1457]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=223387 B4U56_RS04580 WP_001830374.1 932873..933919(+) (vraS) [Staphylococcus epidermidis strain 1457]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92