Detailed information NTG0222983

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: A6J72_RS02460
• Genome accession: NZ_CP020433
• Coordinates: 501682..502428 (+)
• Length: 248 a.a.
• NCBI ID: WP_192573667.1
• Uniprot ID: -
• Organism: Streptococcus intermedius strain FDAARGOS_233
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 496682..507428

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J72_RS02410 (A6J72_02400)	-	497042..497260 (-)	219	WP_082311691.1	Blp family class II bacteriocin	-
A6J72_RS02415 (A6J72_02405)	-	497488..497808 (-)	321	WP_021002959.1	hypothetical protein	-
A6J72_RS02420 (A6J72_02410)	-	497959..498249 (-)	291	WP_021002960.1	bacteriocin immunity protein	-
A6J72_RS10085 (A6J72_02415)	-	498316..498534 (-)	219	Protein_476	garvicin Q family class II bacteriocin	-
A6J72_RS02430 (A6J72_02420)	-	498542..498862 (-)	321	WP_039677379.1	hypothetical protein	-
A6J72_RS02440 (A6J72_02430)	-	499539..499760 (-)	222	WP_021002963.1	Blp family class II bacteriocin	-
A6J72_RS02445 (A6J72_02435)	-	500102..500293 (-)	192	WP_021002964.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
A6J72_RS02450 (A6J72_02440)	-	500313..500561 (-)	249	WP_021002965.1	bacteriocin class II family protein	-
A6J72_RS02455 (A6J72_02445)	-	500793..501482 (+)	690	WP_020998895.1	CPBP family intramembrane glutamic endopeptidase	-
A6J72_RS02460 (A6J72_02450)	comE/blpR	501682..502428 (+)	747	WP_192573667.1	response regulator transcription factor	Regulator
A6J72_RS09830	-	502925..503746 (+)	822	WP_225791037.1	sensor histidine kinase	-
A6J72_RS02470 (A6J72_02460)	-	503827..503979 (-)	153	WP_003073362.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
A6J72_RS02475 (A6J72_02465)	-	504076..505437 (-)	1362	WP_082311694.1	bacteriocin secretion accessory protein	-

Sequence

Protein

• Length: 248 a.a.
• Molecular weight: 28724.15 Da
• Isoelectric Point: 8.0388

>NTDB_id=222983 A6J72_RS02460 WP_192573667.1 501682..502428(+) (comE/blpR) [Streptococcus intermedius strain FDAARGOS_233]
MNIFILEDDLTQQYYMETIVEEIIEKHRLQYHHFEVFGKPKQLLEAISEKGSHQVFFLDIEIKTEEKKGLDVAKKIREID
PYAIIVFVTSHSELMPAAFKLQVGALDYLDKSLSKEALKKRIETALLHTENLTGKGLANDSLLFETPHTQIQVPFKDILY
IETSSRPHRLVLYTHRGRTEFTANLSDMLKKEKRFYQCHRSFVVNPANVHQVDKVNHILHFQNGATCLVSRSKIKGLTEA
IAALHRRE

Nucleotide

• Length: 747 bp

>NTDB_id=222983 A6J72_RS02460 WP_192573667.1 501682..502428(+) (comE/blpR) [Streptococcus intermedius strain FDAARGOS_233]
ATGAATATTTTTATTTTAGAAGATGATCTTACTCAACAATATTATATGGAGACTATTGTTGAAGAAATTATCGAAAAACA
TCGTCTTCAATATCACCATTTTGAAGTTTTTGGAAAACCTAAACAATTACTAGAAGCCATATCTGAGAAAGGAAGCCATC
AGGTTTTCTTTTTGGATATTGAAATCAAAACTGAAGAAAAAAAGGGCTTAGACGTCGCCAAAAAGATACGCGAGATAGAT
CCTTATGCCATTATTGTCTTTGTAACCAGTCACTCTGAATTGATGCCGGCAGCGTTTAAACTGCAAGTCGGCGCCCTTGA
CTATCTTGACAAATCGTTATCAAAAGAAGCTTTGAAAAAACGGATCGAAACTGCGCTGCTACATACTGAAAACCTAACAG
GCAAAGGCCTGGCAAACGATTCTCTTCTCTTTGAAACACCTCATACACAAATACAAGTGCCGTTTAAAGATATTCTTTAC
ATTGAAACTTCCTCTCGTCCTCACCGTTTAGTACTTTACACACATAGAGGGCGTACGGAATTTACTGCCAATCTTTCAGA
TATGTTAAAAAAAGAAAAACGGTTCTACCAATGTCATCGTTCCTTTGTTGTTAACCCAGCTAATGTTCATCAAGTGGATA
AAGTAAATCATATCCTTCACTTCCAGAATGGTGCTACTTGTCTTGTTTCTAGATCAAAAATAAAAGGGTTAACAGAAGCT
ATTGCAGCCCTGCACCGGAGGGAATGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-123)

• LytTr DNA-binding domain (LytTR) (151-241)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	49.798	99.597	0.496
comE/comE1	Streptococcus equinus JB1	45.992	95.565	0.44