Detailed information NTG0222976

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: A6J72_RS01320
• Genome accession: NZ_CP020433
• Coordinates: 256736..257968 (-)
• Length: 410 a.a.
• NCBI ID: WP_003072918.1
• Uniprot ID: A0A1L7MUF6
• Organism: Streptococcus intermedius strain FDAARGOS_233
• Function: require for competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	247875..259832	256736..257968	within	0

Gene organization within MGE regions

Location: 247875..259832

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J72_RS01285 (A6J72_01285)	-	247875..248615 (+)	741	WP_082311571.1	amino acid ABC transporter ATP-binding protein	-
A6J72_RS01290 (A6J72_01290)	-	248990..250525 (+)	1536	WP_082311572.1	ATP-binding cassette domain-containing protein	-
A6J72_RS01295 (A6J72_01295)	-	250643..252391 (-)	1749	WP_082311573.1	ABC transporter ATP-binding protein	-
A6J72_RS01300 (A6J72_01300)	-	252381..254117 (-)	1737	WP_082311574.1	ABC transporter ATP-binding protein	-
A6J72_RS01305 (A6J72_01305)	-	254333..255130 (-)	798	WP_009568535.1	formate/nitrite transporter family protein	-
A6J72_RS01310 (A6J72_01310)	-	255306..256013 (-)	708	WP_082311575.1	glucosaminidase domain-containing protein	-
A6J72_RS01315 (A6J72_01315)	yihA	256136..256723 (-)	588	WP_003072916.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
A6J72_RS01320 (A6J72_01320)	clpX	256736..257968 (-)	1233	WP_003072918.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
A6J72_RS01325 (A6J72_09620)	-	258022..258195 (-)	174	WP_003024903.1	hypothetical protein	-
A6J72_RS01330 (A6J72_01325)	-	258195..258707 (-)	513	WP_020998712.1	dihydrofolate reductase	-
A6J72_RS01335 (A6J72_01330)	-	258993..259832 (-)	840	WP_003072923.1	thymidylate synthase	-

Sequence

Protein

• Length: 410 a.a.
• Molecular weight: 45705.19 Da
• Isoelectric Point: 4.3968

>NTDB_id=222976 A6J72_RS01320 WP_003072918.1 256736..257968(-) (clpX) [Streptococcus intermedius strain FDAARGOS_233]
MPTNRTSEMMVYCSFCGKSQEEVQKIIAGNNAFICNECVELAQEIIREELAEEVLADLSEVPKPQELLNILNHYVIGQDR
AKRALAVAVYNHYKRINFHDNREEEDDVELQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQAADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKIIGFGQNNKAIDENSSYMQEIISEDIQKFGLIPELIGRLPVFAALEPLTVEDLVR
ILREPKNALVKQYQTLLSYDDVTLEFDDDALQEIANKAIERKTGARGLRSIIEETMMDIMFEVPSQENVKLVRITKEAVD
GTDKPILETA

Nucleotide

• Length: 1233 bp

>NTDB_id=222976 A6J72_RS01320 WP_003072918.1 256736..257968(-) (clpX) [Streptococcus intermedius strain FDAARGOS_233]
ATGCCTACAAATCGTACGAGCGAAATGATGGTTTATTGTTCTTTTTGTGGTAAAAGTCAAGAAGAAGTTCAAAAAATTAT
TGCAGGAAATAATGCATTTATTTGTAACGAATGTGTGGAATTAGCACAAGAAATTATTAGAGAAGAATTAGCAGAAGAAG
TATTGGCAGACTTGTCGGAAGTACCAAAACCACAAGAATTGCTTAACATTTTAAATCACTATGTAATAGGGCAAGACCGT
GCAAAGCGAGCGCTGGCTGTTGCTGTATACAATCACTATAAACGTATCAATTTTCACGATAATCGTGAAGAAGAGGATGA
TGTCGAATTACAAAAATCCAATATTCTTATGATTGGTCCAACCGGTTCTGGTAAGACTTTTCTTGCTCAAACTTTAGCGA
AAAGTCTAAATGTTCCCTTTGCGATTGCAGATGCAACGGCTTTGACAGAAGCTGGATATGTTGGAGAAGATGTTGAAAAC
ATTCTCTTAAAACTCTTGCAAGCTGCAGATTTTAATATTGAGCGTGCAGAACGTGGCATTATCTATGTAGATGAGATTGA
CAAAATTGCAAAGAAAAGCGAAAATGTCTCTATTACCCGTGATGTGTCTGGTGAAGGCGTTCAGCAAGCTTTGCTTAAAA
TCATTGAAGGGACTGTAGCTAGTGTACCTCCTCAAGGCGGTCGCAAACATCCACAGCAAGAAATGATTCAAGTGGATACT
AAGAATATTCTTTTTATCGTTGGTGGTGCTTTTGACGGAATTGAAGAAATTGTCAAACAACGTCTAGGTGAAAAGATTAT
TGGTTTTGGTCAAAATAACAAAGCTATTGATGAAAATAGTTCTTATATGCAAGAAATTATTTCCGAAGATATTCAAAAAT
TTGGACTCATCCCCGAATTGATTGGTCGTTTACCAGTGTTTGCTGCGCTTGAGCCTTTGACAGTTGAGGATTTGGTACGA
ATTCTTCGTGAGCCAAAGAACGCCCTAGTAAAACAATATCAAACTCTCCTTTCTTATGATGATGTTACATTAGAGTTTGA
TGATGATGCCCTCCAAGAAATTGCCAATAAGGCTATTGAACGTAAGACAGGTGCTCGTGGATTGCGTTCAATTATTGAAG
AAACTATGATGGATATCATGTTTGAAGTTCCAAGTCAAGAAAATGTGAAATTAGTGCGGATTACCAAGGAAGCAGTTGAT
GGAACAGATAAACCGATTTTAGAAACAGCTTAA

Domains

Predicted by InterproScan.

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (313-390)

• AAA domain (Cdc48 subfamily) (AAA_2) (111-306)

3D structure

• AlphaFold DB: A0A1L7MUF6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	86.341	100	0.863
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.706	98.049	0.576