Detailed information NTG0222290

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: A6J61_RS03600
• Genome accession: NZ_CP020406
• Coordinates: 768446..769489 (+)
• Length: 347 a.a.
• NCBI ID: WP_002461334.1
• Uniprot ID: A0A853V5Y6
• Organism: Staphylococcus lugdunensis strain FDAARGOS_222
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 763446..774489

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J61_RS03575 (A6J61_03570)	-	763736..765097 (-)	1362	WP_002477958.1	FAD-dependent oxidoreductase	-
A6J61_RS03580 (A6J61_03575)	-	765231..766211 (-)	981	WP_070648298.1	aromatic acid exporter family protein	-
A6J61_RS03585 (A6J61_03580)	map	766456..767211 (+)	756	WP_002461338.1	type I methionyl aminopeptidase	-
A6J61_RS03590 (A6J61_03585)	-	767337..767723 (+)	387	WP_002477960.1	hypothetical protein	-
A6J61_RS03595 (A6J61_03590)	liaF	767748..768449 (+)	702	WP_002461335.1	cell wall-active antibiotics response protein LiaF	-
A6J61_RS03600 (A6J61_03595)	vraS	768446..769489 (+)	1044	WP_002461334.1	sensor histidine kinase	Regulator
A6J61_RS03605 (A6J61_03600)	vraR	769479..770108 (+)	630	WP_002461333.1	two-component system response regulator VraR	Regulator
A6J61_RS03610 (A6J61_03605)	-	770281..771510 (-)	1230	WP_002461332.1	YihY/virulence factor BrkB family protein	-
A6J61_RS03615 (A6J61_03610)	-	771713..771997 (-)	285	WP_080606548.1	YtxH domain-containing protein	-
A6J61_RS03620 (A6J61_03615)	-	772004..772468 (-)	465	WP_002477961.1	low molecular weight protein-tyrosine-phosphatase	-
A6J61_RS03625 (A6J61_03620)	-	772632..772817 (+)	186	WP_002492715.1	DUF1128 domain-containing protein	-
A6J61_RS03630 (A6J61_03625)	-	772887..774068 (+)	1182	WP_207754594.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 39934.41 Da
• Isoelectric Point: 5.9679

>NTDB_id=222290 A6J61_RS03600 WP_002461334.1 768446..769489(+) (vraS) [Staphylococcus lugdunensis strain FDAARGOS_222]
MNHYIRAIGSMLILVYSLMIAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLVIILLCIIVGSILAFKINQQNDWIKT
QVEHAIEGETVGINDQNIELYNETIDLYHTLVPLNQELHRLRMKTQNLTNENYNLNDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETELEPPLDQQIPVLEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHDI
EEFKVPKGLEDHLFRITQEAISNTLRHSKGTKVTVELFNKADYLLLRIQDNGIGFNVDDKVEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSHDN

Nucleotide

• Length: 1044 bp

>NTDB_id=222290 A6J61_RS03600 WP_002461334.1 768446..769489(+) (vraS) [Staphylococcus lugdunensis strain FDAARGOS_222]
ATGAACCACTATATTCGAGCAATCGGCTCAATGTTGATACTAGTGTATAGCTTAATGATTGCTTTTCTGTTTATTGATAA
AGTATTCGTTAATATCATTTACTTTCAAGGCATGTTTTATACACAAATATTTGGAATACCAGTATTCCTTTTCTTAAATT
TGGTTATTATTTTATTATGTATTATTGTGGGCTCTATATTAGCTTTTAAAATCAATCAACAAAATGATTGGATCAAAACA
CAAGTAGAGCATGCAATAGAAGGGGAAACAGTTGGTATAAATGATCAAAATATAGAATTGTATAATGAAACAATTGATTT
ATATCATACATTAGTTCCCTTAAATCAAGAGTTACACCGATTAAGAATGAAAACACAAAACTTAACAAATGAAAATTATA
ATTTAAATGATGTAAAAGTGAAAAAAATAATTGAAGACGAACGTCAACGTCTAGCTCGAGAATTACATGATTCAGTGAGC
CAGCAATTATTTGCAGCCAGTATGATGTTATCTGCAATTAAAGAAACAGAGCTAGAACCACCTTTAGATCAACAAATTCC
AGTTTTAGAAAAAATGGTGCAAGATTCACAACTTGAAATGAGAGCACTCTTATTACATCTAAGACCAATTGGTTTAAAGG
ACAAGTCGTTGGGTGAAGGTATTAAAGATTTAGTCATCGATTTACAGAAAAAAGTACCGATGAAAGTGGTTCACGATATT
GAAGAATTTAAAGTGCCTAAAGGTTTAGAAGATCATTTGTTTAGAATTACTCAAGAAGCCATCTCTAATACTTTAAGACA
TTCAAAAGGAACTAAAGTTACTGTAGAATTATTTAATAAAGCAGATTATTTATTATTAAGAATACAAGATAATGGCATTG
GATTTAATGTTGATGATAAAGTCGAACAAAGTTATGGCTTGAAAAATATGCGCGAACGTGCGTTAGAAATAGGTGCAACA
TTTCATATTGTATCATTGCCTGATTCTGGAACAAGAATAGAGGTTAAAGCACCGTTAAACAAGGAGGATTCACATGACAA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A853V5Y6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	91.066	100	0.911