Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   SPYM18_RS04070 Genome accession   NC_003485
Coordinates   772950..774179 (+) Length   409 a.a.
NCBI ID   WP_002984948.1    Uniprot ID   A0A4U7GJW1
Organism   Streptococcus pyogenes MGAS8232     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 767950..779179
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SPYM18_RS04045 (spyM18_0941) - 768566..769843 (-) 1278 WP_011017677.1 hydroxymethylglutaryl-CoA reductase, degradative -
  SPYM18_RS04050 (spyM18_0942) - 769830..771005 (-) 1176 WP_011017678.1 hydroxymethylglutaryl-CoA synthase -
  SPYM18_RS04055 (spyM18_0943) - 771214..772053 (+) 840 WP_011017679.1 thymidylate synthase -
  SPYM18_RS04060 (spyM18_0944) - 772133..772630 (+) 498 WP_011017680.1 dihydrofolate reductase -
  SPYM18_RS10315 (spyM18_0945) - 772650..772820 (+) 171 WP_002990165.1 hypothetical protein -
  SPYM18_RS04070 (spyM18_0946) clpX 772950..774179 (+) 1230 WP_002984948.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  SPYM18_RS04075 (spyM18_0947) yihA 774189..774788 (+) 600 WP_011017681.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  SPYM18_RS04080 (spyM18_0948) - 774936..775679 (+) 744 WP_002984942.1 hypothetical protein -
  SPYM18_RS04085 (spyM18_0949) - 775737..777836 (-) 2100 WP_011017682.1 AAA family ATPase -
  SPYM18_RS04090 (spyM18_0950) rpiA 778214..778897 (+) 684 WP_011017683.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 44991.44 Da        Isoelectric Point: 4.5775

>NTDB_id=21937 SPYM18_RS04070 WP_002984948.1 772950..774179(+) (clpX) [Streptococcus pyogenes MGAS8232]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=21937 SPYM18_RS04070 WP_002984948.1 772950..774179(+) (clpX) [Streptococcus pyogenes MGAS8232]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATATTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGAGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCTCTTCTGTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTGCGTTCTATTATTGAAGAAA
CAATGCTTGACATTATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-391)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U7GJW1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

88.998

100

0.89
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.603

98.044

0.575

Multiple sequence alignment