Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   CWI64_RS09040 Genome accession   NZ_CP025076
Coordinates   1675492..1676124 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain BHN97x     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1670492..1681124
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CWI64_RS09015 (CWI64_09015) mvaD 1670769..1671722 (+) 954 WP_000373457.1 diphosphomevalonate decarboxylase -
  CWI64_RS09020 (CWI64_09020) - 1671709..1672716 (+) 1008 WP_000562412.1 phosphomevalonate kinase -
  CWI64_RS09025 (CWI64_09025) fni 1672700..1673710 (+) 1011 WP_000210618.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  CWI64_RS09030 (CWI64_09030) liaF 1673788..1674486 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  CWI64_RS09035 (CWI64_09035) - 1674483..1675478 (+) 996 WP_000743682.1 sensor histidine kinase -
  CWI64_RS09040 (CWI64_09040) vraR 1675492..1676124 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  CWI64_RS12350 (CWI64_09045) - 1676125..1676367 (+) 243 Protein_1660 DNA alkylation repair protein -
  CWI64_RS12125 - 1676292..1676894 (+) 603 Protein_1661 DNA alkylation repair protein -
  CWI64_RS09060 (CWI64_09060) - 1677044..1677283 (+) 240 WP_000754501.1 hypothetical protein -
  CWI64_RS09065 (CWI64_09065) cbpG 1677364..1678189 (+) 826 Protein_1663 choline-binding protein CbpG -
  CWI64_RS09070 (CWI64_09070) cbpF 1678208..1679230 (+) 1023 Protein_1664 choline-binding protein CbpF -
  CWI64_RS11820 (CWI64_09075) - 1679358..1680493 (-) 1136 Protein_1665 IS3 family transposase -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=217343 CWI64_RS09040 WP_000698434.1 1675492..1676124(+) (vraR) [Streptococcus pneumoniae strain BHN97x]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=217343 CWI64_RS09040 WP_000698434.1 1675492..1676124(+) (vraR) [Streptococcus pneumoniae strain BHN97x]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGTTTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41

Multiple sequence alignment