Detailed information NTG0021423

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SERP_RS07195
• Genome accession: NC_002976
• Coordinates: 1485358..1486404 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis RP62A
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1480358..1491404

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SERP_RS07165 (SE1417)	-	1480742..1481983 (-)	1242	WP_001832467.1	aminopeptidase	-
SERP_RS07170 (SE1418)	-	1481985..1482200 (-)	216	WP_010959205.1	DUF1128 domain-containing protein	-
SERP_RS07175 (SE1419)	-	1482341..1482805 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
SERP_RS07180 (SE1420)	-	1482813..1483097 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
SERP_RS07185 (SE1421)	-	1483504..1484682 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
SERP_RS07190 (SE1422)	vraR	1484739..1485368 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
SERP_RS07195 (SE1423)	vraS	1485358..1486404 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
SERP_RS07200 (SE1424)	liaF	1486401..1487102 (-)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
SERP_RS07205 (SE1425)	-	1487117..1487503 (-)	387	WP_001830382.1	hypothetical protein	-
SERP_RS07210 (SE1426)	map	1487661..1488416 (-)	756	WP_001830397.1	type I methionyl aminopeptidase	-
SERP_RS07215 (SE1427)	-	1488590..1489576 (+)	987	WP_002457091.1	FUSC family protein	-
SERP_RS07220 (SE1428)	-	1489727..1490263 (-)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=21423 SERP_RS07195 WP_001830374.1 1485358..1486404(-) (vraS) [Staphylococcus epidermidis RP62A]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=21423 SERP_RS07195 WP_001830374.1 1485358..1486404(-) (vraS) [Staphylococcus epidermidis RP62A]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92