Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrB   Type   Machinery gene
Locus tag   BSG37_RS00195 Genome accession   NZ_CP018768
Coordinates   39245..40873 (-) Length   542 a.a.
NCBI ID   WP_001631035.1    Uniprot ID   -
Organism   Staphylococcus aureus strain UCI 28 isolate ST5     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 34641..62993 39245..40873 within 0
SCCmec 39245..78853 39245..40873 within 0


Gene organization within MGE regions


Location: 34641..78853
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BSG37_RS00155 (BSG37_00155) - 35184..35444 (-) 261 Protein_26 IS5/IS1182 family transposase -
  BSG37_RS00160 (BSG37_00160) - 35503..36000 (-) 498 WP_001631030.1 GNAT family N-acetyltransferase -
  BSG37_RS00170 (BSG37_00170) - 36672..37079 (-) 408 WP_031865378.1 DUF2871 domain-containing protein -
  BSG37_RS15235 (BSG37_00175) - 37242..37462 (-) 221 Protein_29 hypothetical protein -
  BSG37_RS00180 (BSG37_00180) - 37477..37980 (-) 504 WP_001631032.1 DUF1643 domain-containing protein -
  BSG37_RS00185 (BSG37_00185) - 37996..38307 (-) 312 WP_001631033.1 DUF960 domain-containing protein -
  BSG37_RS00190 (BSG37_00190) - 38394..38744 (-) 351 WP_001631034.1 SAUGI family uracil-DNA glycosylase inhibitor -
  BSG37_RS00195 (BSG37_00195) ccrB 39245..40873 (-) 1629 WP_001631035.1 cassette chromosome recombinase CcrB Machinery gene
  BSG37_RS00200 (BSG37_00200) ccrA 40870..42231 (-) 1362 WP_001631036.1 cassette chromosome recombinase CcrA Machinery gene
  BSG37_RS00205 (BSG37_00205) - 42418..43047 (-) 630 Protein_35 hypothetical protein -
  BSG37_RS00210 (BSG37_00210) - 43056..43394 (+) 339 Protein_36 recombinase family protein -
  BSG37_RS00215 (BSG37_00215) - 43506..43865 (-) 360 WP_001631039.1 hypothetical protein -
  BSG37_RS00220 (BSG37_00220) - 44072..44398 (+) 327 WP_000391495.1 ArsR/SmtB family transcription factor -
  BSG37_RS00225 (BSG37_00225) - 44728..46653 (+) 1926 WP_002485723.1 heavy metal translocating P-type ATPase -
  BSG37_RS00230 (BSG37_00230) - 47981..49237 (+) 1257 WP_000566670.1 MrcB family domain-containing protein -
  BSG37_RS00235 (BSG37_00235) - 49652..49891 (+) 240 WP_001282728.1 hypothetical protein -
  BSG37_RS00240 (BSG37_00240) - 49923..50597 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  BSG37_RS00245 (BSG37_00245) - 50688..51671 (-) 984 Protein_43 protein rep -
  BSG37_RS00250 (BSG37_00250) mobV 51916..53178 (-) 1263 WP_000119405.1 MobV family relaxase -
  BSG37_RS00255 (BSG37_00255) bleO 53685..54089 (-) 405 WP_031879245.1 bleomycin binding protein -
  BSG37_RS00260 (BSG37_00260) aadD1 54306..55067 (-) 762 WP_001014230.1 aminoglycoside O-nucleotidyltransferase ANT(4')-Ia -
  BSG37_RS00265 (BSG37_00265) - 55269..55943 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  BSG37_RS00270 (BSG37_00270) - 56208..56951 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  BSG37_RS00275 (BSG37_00275) - 57048..57476 (+) 429 WP_000872606.1 MaoC family dehydratase -
  BSG37_RS00280 (BSG37_00280) mecA 57522..59531 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  BSG37_RS00285 (BSG37_00285) mecR1 59628..61385 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  BSG37_RS00290 (BSG37_00290) mecI 61385..61756 (+) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  BSG37_RS15020 psm-mec 61841..61909 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  BSG37_RS00305 (BSG37_00305) - 62243..63373 (+) 1131 WP_010922808.1 ROK family transcriptional regulator -
  BSG37_RS00310 (BSG37_00310) cstB 63487..64821 (-) 1335 Protein_55 persulfide dioxygenase-sulfurtransferase CstB -
  BSG37_RS00315 (BSG37_00315) - 64854..65918 (-) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  BSG37_RS00320 (BSG37_00320) cstR 66053..66313 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  BSG37_RS00325 (BSG37_00325) - 66313..66951 (+) 639 Protein_58 sulfite exporter TauE/SafE family protein -
  BSG37_RS00335 (BSG37_00335) - 67296..67958 (-) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  BSG37_RS15510 - 68350..68409 (+) 60 WP_010959190.1 erythromycin resistance leader peptide -
  BSG37_RS00345 (BSG37_00345) erm(A) 68459..69190 (+) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  BSG37_RS00350 (BSG37_00350) - 69316..70098 (-) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  BSG37_RS00355 (BSG37_00355) - 70249..70626 (-) 378 WP_000361059.1 DUF6262 family protein -
  BSG37_RS00360 (BSG37_00360) - 70633..72525 (-) 1893 WP_001557544.1 site-specific integrase -
  BSG37_RS00365 (BSG37_00365) - 72522..73607 (-) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  BSG37_RS00370 (BSG37_00370) - 73726..74043 (-) 318 WP_000659050.1 JAB domain-containing protein -
  BSG37_RS00375 (BSG37_00375) - 74064..74570 (-) 507 WP_001092169.1 DUF1643 domain-containing protein -
  BSG37_RS00380 (BSG37_00380) - 74588..74899 (-) 312 WP_000700853.1 DUF960 family protein -
  BSG37_RS00385 (BSG37_00385) - 74986..75336 (-) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  BSG37_RS00390 (BSG37_00390) ccrB 75854..77482 (-) 1629 WP_001186602.1 cassette chromosome recombinase CcrB Machinery gene
  BSG37_RS00395 (BSG37_00395) ccrA 77504..78853 (-) 1350 WP_000815646.1 cassette chromosome recombinase CcrA Machinery gene

Sequence

Protein


Download         Length: 542 a.a.        Molecular weight: 62474.71 Da        Isoelectric Point: 9.6103

>NTDB_id=210075 BSG37_RS00195 WP_001631035.1 39245..40873(-) (ccrB) [Staphylococcus aureus strain UCI 28 isolate ST5]
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE

Nucleotide


Download         Length: 1629 bp        

>NTDB_id=210075 BSG37_RS00195 WP_001631035.1 39245..40873(-) (ccrB) [Staphylococcus aureus strain UCI 28 isolate ST5]
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA

Domains

Predicted by InterproScan.

Ogr/Delta-like zinc finger (Ogr_Delta)

(300-355)

Resolvase, N terminal domain (Resolvase)

(11-154)

Recombinase (Recombinase)

(179-280)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrB Staphylococcus aureus N315

72.694

100

0.727

Multiple sequence alignment