Detailed information NTG0020873

Bioinformatically predicted

Overview

• Name: vicK
• Type: Regulator
• Locus tag: SPY_RS02240
• Genome accession: NC_002737
• Coordinates: 427084..428436 (+)
• Length: 450 a.a.
• NCBI ID: WP_002995609.1
• Uniprot ID: A0A4U7GC27
• Organism: Streptococcus pyogenes M1 GAS
• Function: repress comCDE expression; repress comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 422084..433436

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPY_RS02215	-	422233..422382 (+)	150	WP_011285429.1	hypothetical protein	-
SPY_RS02220 (SPy0524)	-	422777..423925 (+)	1149	WP_010921988.1	acetyl-CoA C-acyltransferase	-
SPY_RS02225 (SPy0526)	-	423882..425129 (+)	1248	WP_010921989.1	AMP-binding protein	-
SPY_RS02230 (SPy0527)	-	425185..426219 (+)	1035	WP_011285430.1	DUF3114 domain-containing protein	-
SPY_RS02235 (SPy0528)	vicR	426381..427091 (+)	711	WP_002985645.1	response regulator YycF	Regulator
SPY_RS02240 (SPy0529)	vicK	427084..428436 (+)	1353	WP_002995609.1	cell wall metabolism sensor histidine kinase VicK	Regulator
SPY_RS02245 (SPy0530)	vicX	428440..429249 (+)	810	WP_002985641.1	MBL fold metallo-hydrolase	Regulator
SPY_RS02250 (SPy0531)	rnc	429693..430385 (+)	693	WP_002990670.1	ribonuclease III	-

Sequence

Protein

• Length: 450 a.a.
• Molecular weight: 51391.82 Da
• Isoelectric Point: 5.4026

>NTDB_id=20873 SPY_RS02240 WP_002995609.1 427084..428436(+) (vicK) [Streptococcus pyogenes M1 GAS]
MTRDIIGNLSTFELAILILLVFVAFYFIHLAVRDYRNARIIRMMSHKIRDLINGRYTDIIDEKADIELMELSDQLNDLSD
VFRLTHENLAQEKNRLASILAYMSDGVLATDRSGKIIMINETARKQLNLSKEEALKKNITDLLEGDTSYTYRDLVSKTPV
VTVNSRNDMGEFVSLRLRFALNRRESGFISGLVVVLHDTTEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDEGALK
EDIAPSFIKVSLDETNRMMRMISDLLNLSRIDNQVTQLAVEMTNFTAFITSILNRFDLVKNQHTGTGKVYEIVRDYPITS
VWIEIDNDKMTQVIENILNNAIKYSPDGGKITVRMKTTDTQLIISISDQGLGIPKTDLPLIFDRFYRVDKARSRAQGGTG
LGLAIAKEIIKQHHGFIWAKSDYGKGSTFTIVLPYEKDAAIYEEWEEDVD

Nucleotide

• Length: 1353 bp

>NTDB_id=20873 SPY_RS02240 WP_002995609.1 427084..428436(+) (vicK) [Streptococcus pyogenes M1 GAS]
ATGACTAGAGATATCATTGGAAACTTATCCACATTTGAATTAGCGATCCTTATCTTACTTGTTTTTGTTGCTTTTTACTT
TATCCATCTTGCGGTGCGTGATTACCGAAATGCACGTATTATTCGGATGATGAGCCATAAAATCCGAGACTTGATTAATG
GTCGCTATACTGATATAATCGACGAAAAAGCAGACATTGAGTTAATGGAGCTTTCAGACCAGTTAAATGACCTGTCAGAT
GTTTTTCGCTTGACGCATGAAAATCTTGCCCAAGAAAAAAATCGCTTGGCAAGTATTTTGGCTTATATGTCAGATGGTGT
ACTTGCTACAGACCGGTCTGGTAAAATCATCATGATTAACGAGACAGCTCGCAAGCAATTAAATTTAAGTAAAGAAGAGG
CACTAAAGAAAAACATTACAGATTTGTTAGAAGGTGATACTTCATATACCTACCGTGATTTGGTATCCAAAACACCAGTG
GTAACTGTTAATAGCCGAAATGATATGGGTGAGTTTGTCTCATTACGCTTGCGCTTTGCGTTGAATAGGAGAGAGAGTGG
TTTTATTTCGGGCTTGGTTGTGGTGCTCCATGACACCACAGAACAGGAAAAAGAAGAACGTGAACGCCGTCTTTTTGTCT
CTAATGTAAGTCATGAATTAAGGACCCCTTTAACTTCGGTTAAATCCTACTTGGAGGCTCTTGATGAAGGTGCACTTAAA
GAAGATATTGCTCCAAGTTTCATAAAAGTTTCTCTTGATGAAACTAATCGGATGATGCGTATGATTTCAGATCTTTTAAA
CCTGTCTCGGATTGATAATCAAGTAACCCAATTAGCAGTAGAGATGACTAATTTTACTGCTTTTATAACTTCTATTTTAA
ACAGATTTGATTTGGTTAAAAATCAGCATACAGGTACAGGAAAAGTCTATGAAATTGTAAGAGATTACCCTATTACCTCT
GTCTGGATTGAAATTGATAATGATAAAATGACACAGGTTATCGAGAATATTTTGAACAATGCCATTAAGTATTCTCCAGA
TGGTGGAAAAATTACAGTCCGTATGAAAACAACAGATACCCAATTAATTATTTCCATTTCAGACCAAGGACTAGGTATCC
CTAAAACAGATTTGCCTCTTATTTTTGATCGGTTCTATCGTGTAGACAAGGCAAGAAGTCGTGCCCAAGGAGGGACCGGT
CTAGGCCTTGCCATTGCTAAAGAAATCATCAAGCAGCACCATGGCTTTATCTGGGCTAAGAGTGACTATGGTAAAGGATC
GACCTTTACTATTGTCTTGCCTTATGAAAAAGATGCAGCCATCTATGAAGAATGGGAGGAAGATGTAGACTAA

Domains

Predicted by InterproScan.

• PAS fold (PAS) (95-162)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (326-436)

• His Kinase A (phospho-acceptor) domain (HisKA) (209-273)

3D structure

• AlphaFold DB: A0A4U7GC27

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vicK	Streptococcus mutans UA159	72.947	92	0.671
micB	Streptococcus pneumoniae Cp1015	67.765	94.444	0.64