Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   CRD75_RS06740 Genome accession   NZ_CP023769
Coordinates   1323496..1324137 (-) Length   213 a.a.
NCBI ID   WP_002983671.1    Uniprot ID   A0A0H2UW05
Organism   Streptococcus pyogenes strain HarveyGAS     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 1318496..1329137
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CRD75_RS06715 (CRD75_06715) comFA/cflA 1318582..1319907 (-) 1326 WP_011285044.1 DEAD/DEAH box helicase Machinery gene
  CRD75_RS06720 (CRD75_06720) - 1319963..1320595 (+) 633 WP_002988970.1 YigZ family protein -
  CRD75_RS06725 (CRD75_06725) cysK 1320723..1321664 (+) 942 WP_011285046.1 cysteine synthase A -
  CRD75_RS06730 (CRD75_06730) - 1321682..1322059 (-) 378 WP_002991882.1 S1 RNA-binding domain-containing protein -
  CRD75_RS06735 (CRD75_06735) - 1322059..1323459 (-) 1401 WP_021340868.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  CRD75_RS06740 (CRD75_06740) vraR 1323496..1324137 (-) 642 WP_002983671.1 response regulator transcription factor Regulator
  CRD75_RS06745 (CRD75_06745) - 1324130..1325134 (-) 1005 WP_002991890.1 sensor histidine kinase -
  CRD75_RS06750 (CRD75_06750) liaF 1325131..1325823 (-) 693 WP_011054833.1 cell wall-active antibiotics response protein LiaF -
  CRD75_RS06755 (CRD75_06755) pknB 1325946..1327844 (-) 1899 WP_002994648.1 Stk1 family PASTA domain-containing Ser/Thr kinase Regulator
  CRD75_RS06760 (CRD75_06760) - 1327841..1328581 (-) 741 WP_002983660.1 Stp1/IreP family PP2C-type Ser/Thr phosphatase -

Sequence

Protein


Download         Length: 213 a.a.        Molecular weight: 23751.43 Da        Isoelectric Point: 5.1641

>NTDB_id=208593 CRD75_RS06740 WP_002983671.1 1323496..1324137(-) (vraR) [Streptococcus pyogenes strain HarveyGAS]
MSKIKVILVDDHEMVRMGLKSFLNLQADIDVVGEASNGREGVDLALALKPDVLVMDLVMPELGGVEATLEVLKKWKEAKV
LVLTSYLDNEKIYPVIDAGAKGYMLKTSSAAEILNAIRKVSKGELAIETEVDKKIKAHDQHPDLHEELTAREYDILHLLA
KGYDNQTIADELFISLKTVKTHVSNILAKLEVDDRTQAVVYAFRHHLVPQDDN

Nucleotide


Download         Length: 642 bp        

>NTDB_id=208593 CRD75_RS06740 WP_002983671.1 1323496..1324137(-) (vraR) [Streptococcus pyogenes strain HarveyGAS]
ATGAGTAAGATAAAAGTGATATTGGTCGATGATCATGAAATGGTCCGCATGGGACTCAAGAGTTTTTTGAATTTACAAGC
TGATATTGATGTCGTTGGTGAGGCCTCTAATGGACGTGAAGGGGTTGATTTGGCATTGGCTTTGAAGCCAGATGTTTTGG
TTATGGATCTAGTGATGCCAGAGTTAGGCGGTGTTGAGGCAACTTTAGAAGTTCTAAAAAAATGGAAAGAGGCTAAGGTA
CTTGTGTTAACTTCCTATCTAGATAATGAAAAGATATACCCTGTCATTGATGCAGGAGCGAAGGGTTATATGTTAAAAAC
ATCGAGTGCGGCTGAAATTTTAAATGCCATTCGCAAGGTTTCAAAGGGAGAGTTAGCTATTGAAACAGAAGTTGACAAAA
AAATTAAGGCGCATGATCAACACCCTGACTTGCATGAGGAACTAACAGCGCGTGAGTATGATATTTTACACCTTTTAGCT
AAAGGGTATGATAATCAGACCATCGCTGATGAACTCTTTATTTCCTTAAAAACCGTCAAAACACATGTGTCCAATATTCT
AGCCAAGTTAGAAGTTGATGACCGAACCCAAGCGGTTGTCTATGCTTTTCGACATCATTTAGTCCCCCAAGACGATAATT
AA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(6-118)

Bacterial regulatory proteins, luxR family (GerE)

(148-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UW05

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.913

96.714

0.512
  degU Bacillus subtilis subsp. subtilis str. 168

36.283

100

0.385

Multiple sequence alignment