Detailed information NTG0208253

Bioinformatically predicted

Overview

• Name: cclA/cilC
• Type: Machinery gene
• Locus tag: BSL41_RS11185
• Genome accession: NZ_CP018347
• Coordinates: 2032545..2033204 (+)
• Length: 219 a.a.
• NCBI ID: WP_000565017.1
• Uniprot ID: A0A0E8GKN8
• Organism: Streptococcus pneumoniae strain SWU02
• Function: processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology) DNA binding and uptake

Genomic Context

Location: 2027545..2038204

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BSL41_RS11145	mgaSpn	2027701..2029182 (-)	1482	WP_001205280.1	virulence factor transcriptional regulator MgaSpn	-
BSL41_RS11150	-	2029625..2029789 (+)	165	WP_001809002.1	GlsB/YeaQ/YmgE family stress response membrane protein	-
BSL41_RS11155	amaP	2029873..2030439 (+)	567	WP_000030213.1	alkaline shock response membrane anchor protein AmaP	-
BSL41_RS11160	-	2030451..2030621 (+)	171	WP_000455066.1	DUF2273 domain-containing protein	-
BSL41_RS11165	-	2030660..2031268 (+)	609	WP_000064115.1	Asp23/Gls24 family envelope stress response protein	-
BSL41_RS11170	-	2031299..2031502 (+)	204	WP_000109957.1	CsbD family protein	-
BSL41_RS11175	-	2031612..2031851 (-)	240	WP_001005783.1	transposase	-
BSL41_RS11180	-	2032029..2032475 (-)	447	WP_000155421.1	GNAT family N-acetyltransferase	-
BSL41_RS11185	cclA/cilC	2032545..2033204 (+)	660	WP_000565017.1	A24 family peptidase	Machinery gene
BSL41_RS11190	-	2033256..2034407 (-)	1152	WP_000481747.1	ImmA/IrrE family metallo-endopeptidase	-
BSL41_RS11195	-	2034422..2035153 (-)	732	WP_000934017.1	hypothetical protein	-
BSL41_RS11200	-	2035373..2035483 (+)	111	Protein_2020	prepilin peptidase	-
BSL41_RS11205	trpA	2035455..2036231 (-)	777	WP_001127048.1	tryptophan synthase subunit alpha	-
BSL41_RS11210	trpB	2036224..2037447 (-)	1224	WP_000331287.1	tryptophan synthase subunit beta	-
BSL41_RS11215	-	2037425..2038024 (-)	600	WP_000169887.1	phosphoribosylanthranilate isomerase	-

Sequence

Protein

• Length: 219 a.a.
• Molecular weight: 24879.99 Da
• Isoelectric Point: 7.6418

>NTDB_id=208253 BSL41_RS11185 WP_000565017.1 2032545..2033204(+) (cclA/cilC) [Streptococcus pneumoniae strain SWU02]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFRCRYCKVRYPVWYALFELVLG
LLFLLYSWELLSLGQVVLITAGLTLGIYDFHHQEYPLLVWMTFHLILIASSGWNLVMVSFLALGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFILQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide

• Length: 660 bp

>NTDB_id=208253 BSL41_RS11185 WP_000565017.1 2032545..2033204(+) (cclA/cilC) [Streptococcus pneumoniae strain SWU02]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTCGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTTCGCTGTCGCTACTGCAAAGTTCGCTATCCTGTCTGGTATGCCCTCTTTGAATTAGTCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTGCTTTCCTTGGGGCAAGTCGTCCTAATCACCGCTGGTTTGACCTTGGGTAT
CTACGACTTTCACCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTTGCTCTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGCGCAGGAGATTTCCTC
TTTTTAGCTTCTTGTGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTTGCTTCTGCGACGGGTATCCT
GGCCTTTATCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTTTGA

Domains

Predicted by InterproScan.

• Bacterial Peptidase A24 N-terminal domain (A24_N_bact) (8-89)

3D structure

• AlphaFold DB: A0A0E8GKN8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
cclA/cilC	Streptococcus pneumoniae TIGR4	96.804	100	0.968
cclA/cilC	Streptococcus pneumoniae Rx1	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae D39	95.89	100	0.959
cclA/cilC	Streptococcus pneumoniae R6	95.89	100	0.959
cclA/cilC	Streptococcus mitis SK321	92.237	100	0.922
cclA/cilC	Streptococcus mitis NCTC 12261	85.845	100	0.858