Detailed information NTG0207489

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: CO204_RS10270
• Genome accession: NZ_CP023477
• Coordinates: 2019055..2021604 (-)
• Length: 849 a.a.
• NCBI ID: WP_106006866.1
• Uniprot ID: -
• Organism: Streptococcus mutans strain LAR01
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 2014055..2026604

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CO204_RS10250 (CO204_10195)	-	2015184..2015744 (-)	561	WP_002268198.1	DNA-3-methyladenine glycosylase I	-
CO204_RS10255 (CO204_10200)	ruvA	2015826..2016419 (-)	594	WP_002262395.1	Holliday junction branch migration protein RuvA	Machinery gene
CO204_RS10260 (CO204_10205)	hexB	2016602..2018557 (-)	1956	WP_002268465.1	DNA mismatch repair endonuclease MutL	Machinery gene
CO204_RS10265 (CO204_10210)	-	2018782..2019060 (+)	279	Protein_1936	transposase	-
CO204_RS10270 (CO204_10215)	hexA	2019055..2021604 (-)	2550	WP_106006866.1	DNA mismatch repair protein MutS	Machinery gene
CO204_RS10275 (CO204_10220)	-	2021597..2021944 (-)	348	WP_002264540.1	YlbF family regulator	-
CO204_RS10280 (CO204_10225)	argR	2021941..2022378 (-)	438	WP_002262400.1	arginine repressor	-
CO204_RS10285 (CO204_10230)	-	2022775..2023299 (-)	525	WP_019313459.1	Crp/Fnr family transcriptional regulator	-
CO204_RS10785	-	2023676..2023900 (-)	225	WP_002266969.1	hypothetical protein	-
CO204_RS10295 (CO204_10240)	-	2024205..2024675 (+)	471	Protein_1942	arginine repressor	-
CO204_RS10300 (CO204_10245)	argS	2024776..2026467 (+)	1692	WP_002269689.1	arginine--tRNA ligase	-

Sequence

Protein

• Length: 849 a.a.
• Molecular weight: 95381.75 Da
• Isoelectric Point: 5.0240

>NTDB_id=207489 CO204_RS10270 WP_106006866.1 2019055..2021604(-) (hexA) [Streptococcus mutans strain LAR01]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYDDAIKAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLI
DLGYKVAIAEQMEDPKKAVGVVKREVVQVITPGTVVDSTKPDSANNFLVSLDTDGSQFGLSYMDLSTGEFYATTLADLPA
VRSEVLNLKTRELVIGFELSENEEQLFRKQMNLLLSFEKTVYDDVHLLNDQLKAIELAAAGKLLQYVHNTQKRELSHLQK
LVHYEIKDYLQMAYATKSSLDLLENARSGKKHGSLYWLLDETKTAMGTRLLRTWIDRPLVSSSLISKRQDIIQTFLDHFF
ERSDLSDSLKGVYDIERLASRVSFGKANPKDLLQLGQTLSQVPVIKTILESFASSSLESLINQIDTLPELEVLIRSAIDS
NAPITITEGGMIREGFDETLDKYRTVMREGTSWIADIETKERQKSGISTLKIDYNKKDGYYFHVTNSNLSLVPDYFFRKA
TLKNSERFGTAELAKIEGEMLEAREESANLEYDIFMRIRSQVESYIERLQNLAKSLATVDVLQSLAVVAENNHYVRPSFN
HQQEISIENGRHAVVEKVMGSQEYIPNTINFDQKTSIQLITGPNMSGKSTYMRQLALTVIMAQLGSFVAADSADLPIFDA
IFTRIGAADDLISGQSTFMVEMMEANHAIKAATPNSLILFDELGRGTATYDGMALAQAIIEYIHNKVGAKTLFATHYHEL
TDLSTRLTSLVNVHVATLEKDGEVTFLHKIADGPADKSYGIHVAKIAGLPKDLLNRADHILVDLEKMSAAVSVNLKNETK
ESQPVEEQLSLFAIDNNYEELIKKLKQLDLTNLTPRESMNALFDLKELL

Nucleotide

• Length: 2550 bp

>NTDB_id=207489 CO204_RS10270 WP_106006866.1 2019055..2021604(-) (hexA) [Streptococcus mutans strain LAR01]
ATGACTAAGGAAAAACTCTCTCCAGGAATGCAGCAGTATTTGGATATCAAAAAAGACTATCCAGATGCTTTTTTGCTTTT
CCGCATGGGAGATTTTTATGAACTATTTTATGATGATGCTATCAAGGCTGCTCAAATTTTAGAAATTAGCTTAACAAGTC
GTAATAAAAATGCTGACAATCCTATTCCGATGGCTGGTGTCCCTTATCATTCAGCTCAACAGTATATTGATGTTTTGATT
GATTTGGGTTATAAGGTTGCCATTGCTGAGCAGATGGAAGACCCTAAAAAAGCTGTTGGCGTTGTCAAACGTGAAGTGGT
TCAAGTGATTACCCCGGGTACTGTTGTTGATTCAACTAAGCCAGACAGTGCTAATAATTTTTTAGTCTCTCTGGATACTG
ATGGCAGTCAGTTTGGCCTTTCTTACATGGATTTATCTACTGGGGAATTTTATGCGACAACATTAGCAGATTTGCCAGCA
GTGAGAAGCGAAGTCCTCAATCTCAAGACGCGTGAATTAGTTATTGGTTTTGAACTGAGTGAGAATGAAGAACAGCTTTT
TCGTAAGCAGATGAACCTGCTCTTATCTTTTGAAAAAACTGTCTATGACGATGTACATTTATTGAATGATCAATTAAAAG
CAATAGAACTTGCTGCAGCTGGTAAACTCTTGCAATATGTTCATAACACACAAAAACGTGAGTTGAGTCATTTGCAAAAG
TTGGTGCATTATGAAATTAAAGATTACTTACAGATGGCTTATGCTACAAAATCTAGCTTGGATCTGTTAGAAAATGCCAG
AAGCGGGAAAAAACACGGCAGTCTCTACTGGCTTTTAGATGAGACAAAAACAGCTATGGGGACACGCCTTTTGCGAACTT
GGATTGATCGTCCTTTGGTCAGTTCAAGCCTTATCAGTAAACGTCAAGATATTATTCAGACTTTTCTAGATCACTTTTTT
GAGCGCAGTGATCTTAGTGACAGTTTAAAAGGTGTTTATGATATTGAACGTTTGGCCAGCCGTGTTTCATTTGGGAAGGC
CAATCCTAAAGATTTATTGCAATTGGGTCAGACCTTAAGTCAAGTTCCTGTCATTAAGACTATTCTTGAAAGTTTTGCCA
GTTCTAGTTTGGAAAGCCTAATTAATCAGATTGATACTCTTCCAGAATTGGAAGTATTGATTCGTTCGGCTATTGACTCT
AATGCACCTATAACTATTACAGAAGGCGGTATGATTCGAGAGGGGTTTGATGAAACTTTAGATAAGTATCGAACGGTAAT
GCGCGAAGGGACGAGTTGGATTGCTGACATTGAGACTAAGGAACGTCAGAAAAGCGGCATCTCAACCTTGAAGATTGATT
ATAACAAAAAAGACGGTTATTATTTCCATGTCACCAACTCTAATTTGTCTTTAGTACCAGATTACTTCTTTAGAAAGGCA
ACGCTTAAAAATTCTGAGCGCTTTGGGACAGCAGAGCTTGCAAAAATTGAAGGTGAAATGTTAGAAGCGCGTGAAGAATC
AGCCAATTTAGAATATGATATTTTCATGCGTATCAGATCACAGGTTGAATCTTATATTGAGCGTCTTCAAAATCTGGCCA
AGAGTCTAGCAACTGTTGATGTTTTGCAAAGTTTAGCAGTAGTAGCTGAGAATAATCATTATGTCAGACCTTCTTTTAAT
CATCAGCAGGAAATCAGTATTGAAAATGGTCGCCATGCTGTTGTTGAGAAGGTTATGGGAAGCCAAGAATATATTCCCAA
TACTATCAATTTTGACCAAAAGACTAGTATTCAACTGATTACTGGACCTAATATGAGCGGTAAGTCAACTTACATGCGGC
AATTAGCTCTGACAGTTATTATGGCTCAATTAGGTTCTTTTGTAGCAGCTGATTCAGCTGATTTGCCGATTTTTGATGCT
ATTTTTACACGTATTGGTGCTGCAGATGATTTAATTTCAGGGCAGTCTACCTTTATGGTAGAGATGATGGAAGCCAATCA
TGCTATCAAGGCAGCGACACCTAATTCACTCATTTTATTTGATGAATTAGGACGTGGTACAGCAACTTATGATGGTATGG
CTTTAGCACAGGCTATTATTGAGTATATTCATAATAAAGTTGGGGCTAAAACGCTATTTGCTACCCATTATCATGAGTTG
ACAGACTTGTCAACTAGATTGACAAGTCTTGTCAATGTACATGTTGCTACTCTTGAAAAAGATGGAGAGGTCACTTTTCT
TCATAAAATTGCTGATGGACCAGCTGATAAATCTTATGGAATCCATGTTGCTAAAATTGCCGGCTTGCCTAAAGATTTAC
TTAATCGAGCTGATCACATATTAGTTGATTTAGAAAAAATGAGTGCAGCTGTCTCAGTCAATCTTAAAAACGAGACCAAA
GAAAGCCAACCTGTGGAAGAGCAGTTGTCACTTTTTGCTATTGATAATAATTATGAAGAATTAATCAAAAAATTGAAACA
GTTGGACCTTACCAATTTAACACCAAGAGAATCCATGAATGCCTTATTTGATTTGAAGGAACTATTATAA

Domains

Predicted by InterProScan.

• MutS domain II (MutS_II) (126-239)

• MutS domain I (MutS_I) (8-118)

• MutS family domain IV (MutS_IV) (415-506)

• MutS domain III (MutS_III) (256-546)

• MutS domain V (MutS_V) (599-785)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	72.033	100	0.722
mutS	Pseudomonas stutzeri strain ATCC 17587	37.34	100	0.377