Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicK   Type   Regulator
Locus tag   BSR14_RS05320 Genome accession   NZ_CP018186
Coordinates   1195315..1196655 (-) Length   446 a.a.
NCBI ID   WP_002885062.1    Uniprot ID   A0A0F3HCD0
Organism   Streptococcus salivarius strain ICDC1     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1191065..1203807 1195315..1196655 within 0


Gene organization within MGE regions


Location: 1191065..1203807
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BSR14_RS05285 (BSR14_05340) - 1191065..1191742 (+) 678 WP_045771627.1 helix-turn-helix domain-containing protein -
  BSR14_RS10340 (BSR14_05345) - 1191739..1192704 (+) 966 WP_045771628.1 IS3 family transposase -
  BSR14_RS05300 (BSR14_05350) tnpA 1192977..1193393 (-) 417 WP_002886752.1 IS200/IS605 family transposase -
  BSR14_RS05305 (BSR14_05355) - 1193631..1193907 (-) 277 Protein_993 ISL3 family transposase -
  BSR14_RS05310 (BSR14_05360) - 1194079..1194438 (-) 360 WP_156209757.1 YbaN family protein -
  BSR14_RS05315 (BSR14_05365) vicX 1194497..1195309 (-) 813 WP_002885031.1 MBL fold metallo-hydrolase Regulator
  BSR14_RS05320 (BSR14_05370) vicK 1195315..1196655 (-) 1341 WP_002885062.1 cell wall metabolism sensor histidine kinase VicK Regulator
  BSR14_RS05325 (BSR14_05375) vicR 1196648..1197355 (-) 708 WP_049554316.1 response regulator YycF Regulator
  BSR14_RS05330 (BSR14_05380) - 1197641..1198408 (+) 768 WP_038675884.1 amino acid ABC transporter ATP-binding protein -
  BSR14_RS05335 (BSR14_05385) - 1198418..1199251 (+) 834 WP_156209759.1 transporter substrate-binding domain-containing protein -
  BSR14_RS05340 (BSR14_05390) - 1199269..1199967 (+) 699 WP_014633207.1 amino acid ABC transporter permease -
  BSR14_RS05345 (BSR14_05395) - 1199979..1200629 (+) 651 WP_002886253.1 amino acid ABC transporter permease -
  BSR14_RS05350 (BSR14_05400) - 1200817..1201584 (+) 768 WP_038675884.1 amino acid ABC transporter ATP-binding protein -
  BSR14_RS05355 (BSR14_05405) - 1201596..1202429 (+) 834 WP_111686600.1 transporter substrate-binding domain-containing protein -
  BSR14_RS05360 (BSR14_05410) - 1202447..1203145 (+) 699 WP_014633207.1 amino acid ABC transporter permease -
  BSR14_RS05365 (BSR14_05415) - 1203157..1203807 (+) 651 WP_002886253.1 amino acid ABC transporter permease -

Sequence

Protein


Download         Length: 446 a.a.        Molecular weight: 50945.21 Da        Isoelectric Point: 5.1606

>NTDB_id=206787 BSR14_RS05320 WP_002885062.1 1195315..1196655(-) (vicK) [Streptococcus salivarius strain ICDC1]
MTSIGLNITSFELALLFTLLFVAFYFIFLAYRDYRRVKNIRKLTKRVKSLMAGNYNEELRLKGDPELLELADSLNDLSDV
FRLTHENLAQEKNRLSSVLSYMSDGVIATNRRGQITMINSTAQRLLNLDYETATQMSILDLLDGENPYTYSELLSKTPEI
HLSRRDANDEFVTLRVNFALIRKESGFISGLVAVLHDATEQEKEERERRLFVSNVSHELRTPLTSVKSYLEALDDGALDE
EIAPNFIKVSLDETNRMMRMISDLLALSRIDNKSTQLDVEMTNFTAFMTYILNRFDQIKSQETNTGKTYEIIRDYPVNSI
WVEIDTDKMTQVVDNILNNAIKYSPDGGKITVSMKTTDSQLIVSISDQGLGIPKKDLPLIFDRFYRVDKARSRAQGGTGL
GLSIAKEIIKQHKGFIWAKSEYGKGSTFTIVLPYDKDAMMVDEWEM

Nucleotide


Download         Length: 1341 bp        

>NTDB_id=206787 BSR14_RS05320 WP_002885062.1 1195315..1196655(-) (vicK) [Streptococcus salivarius strain ICDC1]
ATGACTAGTATTGGCTTAAACATCACAAGCTTTGAACTAGCCTTACTCTTTACGCTCCTCTTTGTGGCTTTCTACTTTAT
TTTTCTGGCTTATCGTGATTATCGACGAGTCAAAAATATTCGAAAGTTGACCAAGAGGGTCAAGTCCTTAATGGCAGGTA
ACTATAACGAGGAGTTACGCTTAAAGGGTGATCCAGAGCTTTTAGAGCTAGCTGACAGCTTGAATGATTTATCGGATGTC
TTTCGTTTGACGCATGAAAATCTAGCCCAGGAAAAAAACCGCTTATCATCAGTCCTTTCTTACATGAGTGATGGGGTTAT
TGCGACAAATCGTCGTGGTCAAATTACCATGATTAATAGCACAGCTCAGCGTTTGTTGAATCTAGATTATGAAACAGCGA
CACAGATGTCCATTTTAGATTTATTAGATGGCGAAAATCCCTATACTTATAGTGAATTGCTCTCTAAGACTCCTGAAATT
CATTTGTCACGTCGAGATGCCAACGATGAGTTTGTGACCTTACGTGTTAATTTTGCCCTTATTCGTAAAGAATCAGGTTT
TATCTCAGGTCTGGTTGCCGTTCTTCACGATGCCACTGAGCAAGAAAAAGAAGAGCGTGAACGTCGACTCTTCGTCTCAA
ACGTTAGTCATGAGTTGCGTACACCTTTGACTTCTGTAAAATCCTATCTGGAGGCACTTGATGATGGTGCTCTCGACGAA
GAGATTGCTCCTAACTTTATCAAAGTTTCTTTGGATGAGACCAATCGTATGATGCGAATGATTTCTGACCTCTTGGCACT
ATCACGTATTGACAATAAGAGTACCCAACTTGACGTTGAGATGACCAATTTCACGGCCTTCATGACCTATATCTTGAATC
GTTTTGATCAGATTAAAAGTCAAGAAACCAATACAGGTAAAACTTACGAAATCATTCGCGATTATCCGGTAAACTCAATT
TGGGTGGAGATTGATACAGATAAGATGACCCAGGTTGTGGATAATATTCTTAATAATGCTATCAAGTATTCGCCTGATGG
TGGTAAGATTACAGTGTCTATGAAGACAACTGATTCACAGTTGATTGTTTCTATTTCTGACCAAGGTTTGGGTATTCCTA
AGAAAGATTTGCCGTTGATTTTCGACCGTTTTTACCGTGTTGATAAGGCCAGAAGTCGTGCCCAAGGTGGAACTGGTCTA
GGCTTGTCTATTGCAAAAGAAATTATTAAACAACATAAGGGCTTTATTTGGGCTAAGAGTGAGTATGGTAAGGGTTCAAC
TTTTACAATTGTGCTTCCATATGACAAGGATGCCATGATGGTTGATGAATGGGAGATGTAG

Domains

Predicted by InterproScan.

PAS fold (PAS)

(94-197)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(325-435)

His Kinase A (phospho-acceptor) domain (HisKA)

(208-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0F3HCD0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicK Streptococcus mutans UA159

73.671

92.825

0.684
  micB Streptococcus pneumoniae Cp1015

67.667

97.085

0.657

Multiple sequence alignment