Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   BMJ42_RS02525 Genome accession   NZ_CP018136
Coordinates   428587..429276 (+) Length   229 a.a.
NCBI ID   WP_000518008.1    Uniprot ID   A0A0B7KUQ5
Organism   Streptococcus pneumoniae strain SP49     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 423587..434276
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  BMJ42_RS02500 (BMJ42_00473) gpsB 423696..424025 (+) 330 WP_000146522.1 cell division regulator GpsB -
  BMJ42_RS02510 (BMJ42_00475) - 424511..425668 (+) 1158 WP_000711385.1 THUMP domain-containing class I SAM-dependent RNA methyltransferase -
  BMJ42_RS02515 (BMJ42_00476) mapZ 425681..427075 (+) 1395 WP_073176703.1 cell division site-positioning protein MapZ -
  BMJ42_RS02520 (BMJ42_00477) gndA 427151..428575 (+) 1425 WP_000158793.1 NADP-dependent phosphogluconate dehydrogenase -
  BMJ42_RS02525 (BMJ42_00478) covR 428587..429276 (+) 690 WP_000518008.1 response regulator transcription factor Regulator
  BMJ42_RS02530 (BMJ42_00479) cbpC 429374..430393 (+) 1020 WP_000771096.1 choline-binding protein CbpC -
  BMJ42_RS02535 (BMJ42_00480) - 430511..431743 (-) 1233 WP_000765667.1 MFS transporter -
  BMJ42_RS02540 (BMJ42_00481) - 431754..432206 (-) 453 WP_000499617.1 hypothetical protein -
  BMJ42_RS02545 - 432274..432611 (-) 338 Protein_473 lanthionine synthetase LanC family protein -
  BMJ42_RS13820 - 433274..433441 (+) 168 Protein_474 transposase -
  BMJ42_RS13825 - 433481..433603 (+) 123 Protein_475 N-acetylmuramoyl-L-alanine amidase family protein -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26914.21 Da        Isoelectric Point: 6.9836

>NTDB_id=206042 BMJ42_RS02525 WP_000518008.1 428587..429276(+) (covR) [Streptococcus pneumoniae strain SP49]
MGKRILLLEKERNLAHFLSLELQKEQYRVDLVEEGQKALSMALQTDYDLILLNVNLGDMMAQDFAEKLSRTKPASVIMIL
DHWEDLQEELEVVQRFAVSYIYKPVFIENLVARISAIFRGRDFIDQHCSLMKVPRTYRNLRIDVEHHTVYRGEEMIALTR
REYDLLATLMGSKKVLTREQLLESVWKYESATETNIVDVYIRYLRSKLDVKGQKSYIKTVRGVGYTMQE

Nucleotide


Download         Length: 690 bp        

>NTDB_id=206042 BMJ42_RS02525 WP_000518008.1 428587..429276(+) (covR) [Streptococcus pneumoniae strain SP49]
ATGGGGAAACGGATTTTATTACTTGAGAAAGAACGAAATCTAGCTCATTTTTTAAGTTTGGAACTCCAGAAAGAGCAGTA
TCGGGTTGATCTGGTAGAGGAGGGGCAAAAAGCCCTTTCCATGGCTCTTCAGACAGACTATGATTTGATTTTATTGAACG
TTAATCTGGGAGATATGATGGCTCAGGATTTTGCAGAAAAATTGAGTCGAACTAAACCTGCCTCAGTCATCATGATTTTA
GATCATTGGGAAGACTTGCAAGAAGAGCTGGAAGTTGTTCAGCGTTTTGCAGTTTCATACATCTATAAGCCAGTCTTTAT
CGAAAATCTGGTAGCGCGTATTTCGGCGATCTTCCGAGGTCGGGACTTCATTGATCAACACTGCAGTCTGATGAAAGTTC
CAAGGACCTACCGCAATCTTAGGATAGATGTTGAACATCACACGGTTTATCGTGGTGAAGAGATGATTGCTCTGACCCGC
CGTGAGTATGACCTTTTGGCGACACTTATGGGAAGCAAGAAAGTATTGACTCGTGAGCAATTGTTGGAAAGTGTTTGGAA
GTATGAAAGTGCGACCGAGACAAATATCGTAGATGTCTATATCCGCTATCTACGGAGCAAGCTTGATGTTAAAGGACAAA
AAAGCTACATTAAAACCGTGCGTGGTGTTGGTTACACCATGCAAGAATAG

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-226)

Response regulator receiver domain (Response_reg)

(5-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7KUQ5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

48.261

100

0.485
  covR Lactococcus lactis subsp. lactis strain DGCC12653

46.522

100

0.467

Multiple sequence alignment