Detailed information NTG0187826

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: BBD27_RS02730
• Genome accession: NZ_CP016394
• Coordinates: 520974..522491 (-)
• Length: 505 a.a.
• NCBI ID: WP_002949640.1
• Uniprot ID: A0A060BQ50
• Organism: Streptococcus thermophilus strain ND07
• Function: repress comR expression (predicted from homology) Competence regulation

Genomic Context

Location: 515974..527491

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
BBD27_RS11835	-	516156..516815 (-)	660	Protein_523	HI_0552 family protein	-
BBD27_RS02710 (BBD27_0544)	der	516879..518189 (-)	1311	WP_014607972.1	ribosome biogenesis GTPase Der	-
BBD27_RS02715 (BBD27_0545)	dnaI	518295..519197 (-)	903	WP_014607971.1	primosomal protein DnaI	-
BBD27_RS02720 (BBD27_0546)	-	519201..520376 (-)	1176	WP_011680739.1	DnaD domain protein	-
BBD27_RS02725 (BBD27_0547)	nrdR	520373..520852 (-)	480	WP_011680738.1	transcriptional regulator NrdR	-
BBD27_RS02730 (BBD27_0548)	covS	520974..522491 (-)	1518	WP_002949640.1	HAMP domain-containing sensor histidine kinase	Regulator
BBD27_RS02735 (BBD27_0549)	covR	522488..523177 (-)	690	WP_002949638.1	response regulator transcription factor	Regulator
BBD27_RS02740 (BBD27_0550)	-	523333..523869 (-)	537	WP_014607968.1	DUF177 domain-containing protein	-
BBD27_RS02745 (BBD27_0551)	rsmG	524166..524879 (+)	714	WP_002946490.1	16S rRNA (guanine(527)-N(7))-methyltransferase RsmG	-
BBD27_RS02750 (BBD27_0552)	-	524949..526313 (+)	1365	WP_011680735.1	TrkH family potassium uptake protein	-
BBD27_RS02755 (BBD27_0553)	-	526353..527024 (+)	672	WP_002946492.1	potassium channel family protein	-
BBD27_RS11360	-	527041..527211 (-)	171	Protein_534	ascorbate 6-phosphate lactonase	-

Sequence

Protein

• Length: 505 a.a.
• Molecular weight: 57536.93 Da
• Isoelectric Point: 5.2689

>NTDB_id=187826 BBD27_RS02730 WP_002949640.1 520974..522491(-) (covS) [Streptococcus thermophilus strain ND07]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAALY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLEFYYALKERLIFLLIFLEVGMTVLVIAVTVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQITIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide

• Length: 1518 bp

>NTDB_id=187826 BBD27_RS02730 WP_002949640.1 520974..522491(-) (covS) [Streptococcus thermophilus strain ND07]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCCTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGGAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAACTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACGATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTTCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGATTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (384-494)

• ArlS sensor domain (ArlS_N) (39-187)

• His Kinase A (phospho-acceptor) domain (HisKA) (270-329)

• HAMP domain (HAMP) (213-265)

3D structure

• AlphaFold DB: A0A060BQ50

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Streptococcus salivarius strain HSISS4	94.622	99.406	0.941