Detailed information NTG0186475

Bioinformatically predicted

Overview

• Name: comD/blpH
• Type: Regulator
• Locus tag: A6J72_RS09830
• Genome accession: NZ_CP020433
• Coordinates: 502925..503746 (+)
• Length: 273 a.a.
• NCBI ID: WP_225791037.1
• Uniprot ID: -
• Organism: Streptococcus intermedius strain FDAARGOS_233
• Function: phosphorylation of ComE; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 497925..508746

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A6J72_RS02420 (A6J72_02410)	-	497959..498249 (-)	291	WP_021002960.1	bacteriocin immunity protein	-
A6J72_RS10085 (A6J72_02415)	-	498316..498534 (-)	219	Protein_476	garvicin Q family class II bacteriocin	-
A6J72_RS02430 (A6J72_02420)	-	498542..498862 (-)	321	WP_039677379.1	hypothetical protein	-
A6J72_RS02440 (A6J72_02430)	-	499539..499760 (-)	222	WP_021002963.1	Blp family class II bacteriocin	-
A6J72_RS02445 (A6J72_02435)	-	500102..500293 (-)	192	WP_021002964.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
A6J72_RS02450 (A6J72_02440)	-	500313..500561 (-)	249	WP_021002965.1	bacteriocin class II family protein	-
A6J72_RS02455 (A6J72_02445)	-	500793..501482 (+)	690	WP_020998895.1	CPBP family intramembrane glutamic endopeptidase	-
A6J72_RS02460 (A6J72_02450)	comE/blpR	501682..502428 (+)	747	WP_192573667.1	response regulator transcription factor	Regulator
A6J72_RS09830	comD/blpH	502925..503746 (+)	822	WP_225791037.1	sensor histidine kinase	Regulator
A6J72_RS02470 (A6J72_02460)	-	503827..503979 (-)	153	WP_003073362.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
A6J72_RS02475 (A6J72_02465)	-	504076..505437 (-)	1362	WP_082311694.1	bacteriocin secretion accessory protein	-
A6J72_RS02480 (A6J72_02470)	comA/nlmT	505448..507598 (-)	2151	WP_082311695.1	peptide cleavage/export ABC transporter	Regulator
A6J72_RS02490 (A6J72_02480)	-	508079..508453 (+)	375	WP_003073369.1	hypothetical protein	-

Sequence

Protein

• Length: 273 a.a.
• Molecular weight: 31216.03 Da
• Isoelectric Point: 6.2742

>NTDB_id=186475 A6J72_RS09830 WP_225791037.1 502925..503746(+) (comD/blpH) [Streptococcus intermedius strain FDAARGOS_233]
MVLYYIILQLLAYIEYTKFTTTLFVREALVIIYLVFFLIITNRLDLHLRERIQSDLMLQKDLQLKNLENYSHHIEELYTE
VRSFRHDYANILTTLKLGIEQNDIDIVKNVYHSVLKDSNKRFRNPKYDIGRLVHIKNDALKSLLAAKFAQAQEHNVSVSL
EVPEDICPQGMELVDFITIVSILCDNAIEAAAPTMTIAYVLSGNKQVFSIENAIKEEHIDMSYIFDAGVSSKGSGRGIGL
SNVLAILDRYPNVSLASTSQNHCFQHILEIHLN

Nucleotide

• Length: 822 bp

>NTDB_id=186475 A6J72_RS09830 WP_225791037.1 502925..503746(+) (comD/blpH) [Streptococcus intermedius strain FDAARGOS_233]
ATGGTATTGTACTATATCATTCTCCAACTATTGGCGTATATAGAATACACTAAATTTACAACAACTCTTTTTGTTAGAGA
AGCATTGGTTATTATTTATCTAGTATTCTTTTTGATTATTACTAACCGACTGGACCTTCATTTACGGGAGAGAATCCAAA
GTGATTTAATGCTTCAAAAAGATTTACAGTTAAAAAACTTGGAAAACTACAGTCATCACATTGAGGAATTGTACACAGAA
GTTCGGAGCTTTCGGCATGATTACGCAAATATTTTAACAACCTTGAAATTAGGAATTGAGCAAAATGATATAGACATTGT
AAAGAATGTCTATCATTCTGTTTTGAAAGATTCCAATAAGCGTTTTCGCAATCCCAAGTATGATATTGGACGGTTAGTCC
ATATCAAAAACGATGCCTTAAAAAGCCTGCTAGCTGCTAAATTTGCACAAGCTCAAGAGCATAATGTATCCGTTTCATTG
GAAGTTCCAGAAGATATTTGTCCACAAGGAATGGAATTAGTTGACTTTATCACCATTGTCTCCATTTTGTGTGATAATGC
GATTGAAGCTGCTGCTCCAACTATGACGATTGCTTATGTTTTGTCAGGAAACAAGCAGGTATTCTCCATTGAAAATGCTA
TAAAAGAAGAGCATATAGACATGTCTTATATTTTTGATGCGGGAGTTAGTTCTAAAGGATCTGGGCGAGGAATTGGATTA
TCAAATGTCTTAGCAATTCTGGATCGATATCCAAATGTTTCACTTGCTAGTACTAGCCAGAATCACTGCTTTCAGCACAT
CCTTGAGATTCATCTGAATTAG

Domains

Predicted by InterProScan.

• GHKL domain (HATPase_c_5) (171-268)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comD/blpH	Streptococcus mutans UA159	44.161	100	0.443
comD/comD3	Streptococcus equinus JB1	39.442	91.941	0.363