Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   A9497_RS07695 Genome accession   NZ_CP016026
Coordinates   1463209..1463898 (+) Length   229 a.a.
NCBI ID   WP_002949638.1    Uniprot ID   A0A060BFD8
Organism   Streptococcus thermophilus strain KLDS SM     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1458209..1468898
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  A9497_RS11440 - 1459175..1459345 (+) 171 Protein_1431 ascorbate 6-phosphate lactonase -
  A9497_RS07675 (A9497_07675) - 1459362..1460033 (-) 672 WP_002946492.1 potassium channel family protein -
  A9497_RS07680 (A9497_07680) - 1460073..1461437 (-) 1365 WP_082324205.1 TrkH family potassium uptake protein -
  A9497_RS07685 (A9497_07685) rsmG 1461507..1462220 (-) 714 WP_002946490.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  A9497_RS07690 (A9497_07690) - 1462517..1463053 (+) 537 WP_014607968.1 DUF177 domain-containing protein -
  A9497_RS07695 (A9497_07695) covR 1463209..1463898 (+) 690 WP_002949638.1 response regulator transcription factor Regulator
  A9497_RS07700 (A9497_07700) covS 1463895..1465412 (+) 1518 WP_002949640.1 HAMP domain-containing sensor histidine kinase Regulator
  A9497_RS07705 (A9497_07705) nrdR 1465534..1466013 (+) 480 WP_011680738.1 transcriptional regulator NrdR -
  A9497_RS07710 (A9497_07710) - 1466010..1467185 (+) 1176 WP_011680739.1 DnaD domain protein -
  A9497_RS07715 (A9497_07715) dnaI 1467189..1468091 (+) 903 WP_014607971.1 primosomal protein DnaI -

Sequence

Protein


Download         Length: 229 a.a.        Molecular weight: 26655.77 Da        Isoelectric Point: 4.7059

>NTDB_id=185400 A9497_RS07695 WP_002949638.1 1463209..1463898(+) (covR) [Streptococcus thermophilus strain KLDS SM]
MSKRILIVEDERNLARFVSLELQHEGYDVVTADNGREGLEMALEKDFDLILLDLMLPEMDGFEVTRRLQQEKDTYIMMMT
ARDSIMDIVAGLDRGADDYIIKPFAIEELLARIRATFRRQDIEATKKAPAKASTYRDLKLDVQNRAVVRGDEVIPLTKRE
FDLLNTLLSNMNQVMTREELLLQVWKYDDVIETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIRER

Nucleotide


Download         Length: 690 bp        

>NTDB_id=185400 A9497_RS07695 WP_002949638.1 1463209..1463898(+) (covR) [Streptococcus thermophilus strain KLDS SM]
ATGAGCAAACGCATTTTGATTGTTGAAGATGAGAGAAACCTTGCTCGTTTTGTCTCTCTTGAACTTCAACACGAAGGATA
CGACGTTGTGACAGCGGACAACGGACGCGAAGGACTTGAAATGGCACTTGAGAAAGATTTCGATCTTATTCTCTTGGACC
TTATGTTGCCTGAGATGGACGGTTTCGAAGTGACACGTCGTCTCCAACAAGAAAAAGATACTTATATTATGATGATGACA
GCTCGCGACTCAATCATGGATATTGTTGCTGGTTTGGATCGTGGAGCTGATGACTATATTATAAAACCATTTGCGATTGA
AGAACTGTTGGCACGTATTCGTGCAACTTTCCGTCGTCAAGATATCGAAGCTACTAAGAAGGCACCAGCTAAAGCGTCAA
CCTATCGCGATTTAAAATTGGATGTTCAAAACCGTGCAGTTGTTCGCGGTGATGAGGTAATTCCATTGACAAAACGTGAG
TTTGATTTGTTGAACACACTTTTAAGCAATATGAACCAAGTAATGACCCGTGAGGAACTCTTGCTTCAAGTCTGGAAATA
TGATGACGTAATTGAAACAAACGTTGTAGATGTTTATATTCGTTACTTACGTGGGAAAATCGACATTCCAGGTAAGGAAT
CATACATTCAAACAGTACGAGGGATGGGTTACGTTATCCGTGAAAGATGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(152-225)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A060BFD8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

96.07

100

0.961
  covR Lactococcus lactis subsp. lactis strain DGCC12653

67.544

99.563

0.672
  vicR Streptococcus mutans UA159

45.259

100

0.459
  micA Streptococcus pneumoniae Cp1015

43.913

100

0.441

Multiple sequence alignment